Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome
Abstract Background Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive breast cancer (IBC). Studies have indicated differences in DCIS outcome based on race or ethnicity, but molecular differences have not been investigated. Methods We examined the molecular profile of DCIS by s...
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BMC
2024-09-01
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| Series: | Breast Cancer Research |
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| Online Access: | https://doi.org/10.1186/s13058-024-01885-8 |
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| author | Siri H. Strand Kathleen E. Houlahan Vernal Branch Lorraine M. King Thomas Lynch Belén Rivero-Guitiérrez Bryan Harmon Fergus Couch Kristalyn Gallagher Mark Kilgore Shi Wei Angela DeMichele Tari King Priscilla McAuliffe Christina Curtis Kouros Owzar Jeffrey R. Marks Graham A. Colditz E. Shelley Hwang Robert B. West |
| author_facet | Siri H. Strand Kathleen E. Houlahan Vernal Branch Lorraine M. King Thomas Lynch Belén Rivero-Guitiérrez Bryan Harmon Fergus Couch Kristalyn Gallagher Mark Kilgore Shi Wei Angela DeMichele Tari King Priscilla McAuliffe Christina Curtis Kouros Owzar Jeffrey R. Marks Graham A. Colditz E. Shelley Hwang Robert B. West |
| author_sort | Siri H. Strand |
| collection | DOAJ |
| description | Abstract Background Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive breast cancer (IBC). Studies have indicated differences in DCIS outcome based on race or ethnicity, but molecular differences have not been investigated. Methods We examined the molecular profile of DCIS by self-reported race (SRR) and outcome groups in Black (n = 99) and White (n = 191) women in a large DCIS case-control cohort study with longitudinal follow up. Results Gene expression and pathway analyses suggested that different genes and pathways are involved in diagnosis and ipsilateral breast outcome (DCIS or IBC) after DCIS treatment in White versus Black women. We identified differences in ER and HER2 expression, tumor microenvironment composition, and copy number variations by SRR and outcome groups. Conclusions Our results suggest that different molecular mechanisms drive initiation and subsequent ipsilateral breast events in Black versus White women. |
| format | Article |
| id | doaj-art-a8fcc0a964614940addf1aa9c93ffeba |
| institution | Kabale University |
| issn | 1465-542X |
| language | English |
| publishDate | 2024-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Breast Cancer Research |
| spelling | doaj-art-a8fcc0a964614940addf1aa9c93ffeba2025-08-24T11:58:42ZengBMCBreast Cancer Research1465-542X2024-09-0126111510.1186/s13058-024-01885-8Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcomeSiri H. Strand0Kathleen E. Houlahan1Vernal Branch2Lorraine M. King3Thomas Lynch4Belén Rivero-Guitiérrez5Bryan Harmon6Fergus Couch7Kristalyn Gallagher8Mark Kilgore9Shi Wei10Angela DeMichele11Tari King12Priscilla McAuliffe13Christina Curtis14Kouros Owzar15Jeffrey R. Marks16Graham A. Colditz17E. Shelley Hwang18Robert B. West19Department of Pathology, Stanford University School of MedicineStanford Cancer Institute, Stanford University School of MedicineNational Breast Cancer CoalitionDepartment of Surgery, Duke University School of MedicineDepartment of Surgery, Duke University School of MedicineDepartment of Pathology, Stanford University School of MedicineDepartment of Pathology, Montefiore Medical CenterDepartment of Pathology, Mayo ClinicDepartment of Surgery, University of North Carolina at Chapel HillDepartment of Pathology, University of WashingtonDepartment of Pathology, University of Alabama at BirminghamDepartment of Medicine, University of PennsylvaniaDepartment of Surgery, Brigham and Women’s HospitalDepartment of Surgery, University of PittsburghStanford Cancer Institute, Stanford University School of MedicineDuke Cancer Institute, Duke University School of MedicineDepartment of Surgery, Duke University School of MedicineDepartment of Surgery, Washington University School of MedicineDepartment of Surgery, Duke University School of MedicineDepartment of Pathology, Stanford University School of MedicineAbstract Background Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive breast cancer (IBC). Studies have indicated differences in DCIS outcome based on race or ethnicity, but molecular differences have not been investigated. Methods We examined the molecular profile of DCIS by self-reported race (SRR) and outcome groups in Black (n = 99) and White (n = 191) women in a large DCIS case-control cohort study with longitudinal follow up. Results Gene expression and pathway analyses suggested that different genes and pathways are involved in diagnosis and ipsilateral breast outcome (DCIS or IBC) after DCIS treatment in White versus Black women. We identified differences in ER and HER2 expression, tumor microenvironment composition, and copy number variations by SRR and outcome groups. Conclusions Our results suggest that different molecular mechanisms drive initiation and subsequent ipsilateral breast events in Black versus White women.https://doi.org/10.1186/s13058-024-01885-8Ductal carcinoma in situBreast cancerOutcomeRecurrenceProgressionRace |
| spellingShingle | Siri H. Strand Kathleen E. Houlahan Vernal Branch Lorraine M. King Thomas Lynch Belén Rivero-Guitiérrez Bryan Harmon Fergus Couch Kristalyn Gallagher Mark Kilgore Shi Wei Angela DeMichele Tari King Priscilla McAuliffe Christina Curtis Kouros Owzar Jeffrey R. Marks Graham A. Colditz E. Shelley Hwang Robert B. West Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome Breast Cancer Research Ductal carcinoma in situ Breast cancer Outcome Recurrence Progression Race |
| title | Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome |
| title_full | Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome |
| title_fullStr | Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome |
| title_full_unstemmed | Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome |
| title_short | Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome |
| title_sort | analysis of ductal carcinoma in situ by self reported race reveals molecular differences related to outcome |
| topic | Ductal carcinoma in situ Breast cancer Outcome Recurrence Progression Race |
| url | https://doi.org/10.1186/s13058-024-01885-8 |
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