Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemia in the northern Dutch-German cross-border region: A 10-y multicentre analysis (2013–2022)
Objective: To analyse the trends in occurrence of enterococcal and vancomycin-resistant Enterococcus faecium (VREfm) bacteraemia in the northern Dutch-German cross-border region. Methods: A retrospective cross-sectional study was conducted using positive blood culture results from two university hos...
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Elsevier
2025-05-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716525000578 |
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| author | Cansu Cimen Andreas Voss Josef Hellkamp Axel Hamprecht Matthijs S. Berends |
| author_facet | Cansu Cimen Andreas Voss Josef Hellkamp Axel Hamprecht Matthijs S. Berends |
| author_sort | Cansu Cimen |
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| description | Objective: To analyse the trends in occurrence of enterococcal and vancomycin-resistant Enterococcus faecium (VREfm) bacteraemia in the northern Dutch-German cross-border region. Methods: A retrospective cross-sectional study was conducted using positive blood culture results from two university hospitals, the University Medical Centre Groningen (UMCG) and the Klinikum Oldenburg (KOL) between 1 January 2013 to 31 December 2022. Results: Over the 10-y period, 738 enterococcal bacteraemia episodes were observed at KOL and 1091 at UMCG, involving 685 and 999 patients, respectively. E. faecium was the predominant species in both institutions (60.3% at KOL and 60.8% at UMCG). The median age of patients with enterococcal, E. faecium, E. faecalis and VREfm bacteraemia was consistently higher at KOL than at UMCG (p= .029). In both institutions, over half of the enterococcal bacteraemia cases (53.4% at KOL, 55.8% at UMCG) were observed in intensive care units and haematology/oncology wards. From 2018 to 2022, UMCG had higher overall incidence rates of E. faecium, and E. faecalis bacteraemia, while KOL had a significantly higher incidence of VREfm (0.56 vs. 0.05 per 10,000 patient-d, p< .0001). There was a significant upward trend in VREfm bacteraemia cases (p= .01) and in the proportion of VREfm among bacteraemia caused by E. faecium (p= .027) at KOL, but such a trend was not observed at UMCG during the study period. Conclusions: The results reveal a significant difference in VREfm bacteraemia occurrences between a German and Dutch hospital in a cross-border region, reflecting national trends yet showing regional variation. |
| format | Article |
| id | doaj-art-a8fc34b9aa744934b893fd7eaf70187e |
| institution | OA Journals |
| issn | 2213-7165 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
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| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-a8fc34b9aa744934b893fd7eaf70187e2025-08-20T02:14:22ZengElsevierJournal of Global Antimicrobial Resistance2213-71652025-05-014218719410.1016/j.jgar.2025.02.022Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemia in the northern Dutch-German cross-border region: A 10-y multicentre analysis (2013–2022)Cansu Cimen0Andreas Voss1Josef Hellkamp2Axel Hamprecht3Matthijs S. Berends4Institute of Medical Microbiology and Virology, University of Oldenburg, Oldenburg, Germany; Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Corresponding author. Mailing address: Cansu Cimen, Institute of Medical Microbiology and Virology, University of Oldenburg, Philosophenweg 36, 26121 Oldenburg, Germany.Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsInstitute of Medical Microbiology and Virology, Klinikum Oldenburg, Oldenburg, GermanyInstitute of Medical Microbiology and Virology, University of Oldenburg, Oldenburg, Germany; Institute of Medical Microbiology and Virology, Klinikum Oldenburg, Oldenburg, GermanyDepartment of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Medical Epidemiology, Certe Medical Diagnostics and Advice Foundation, Groningen, The NetherlandsObjective: To analyse the trends in occurrence of enterococcal and vancomycin-resistant Enterococcus faecium (VREfm) bacteraemia in the northern Dutch-German cross-border region. Methods: A retrospective cross-sectional study was conducted using positive blood culture results from two university hospitals, the University Medical Centre Groningen (UMCG) and the Klinikum Oldenburg (KOL) between 1 January 2013 to 31 December 2022. Results: Over the 10-y period, 738 enterococcal bacteraemia episodes were observed at KOL and 1091 at UMCG, involving 685 and 999 patients, respectively. E. faecium was the predominant species in both institutions (60.3% at KOL and 60.8% at UMCG). The median age of patients with enterococcal, E. faecium, E. faecalis and VREfm bacteraemia was consistently higher at KOL than at UMCG (p= .029). In both institutions, over half of the enterococcal bacteraemia cases (53.4% at KOL, 55.8% at UMCG) were observed in intensive care units and haematology/oncology wards. From 2018 to 2022, UMCG had higher overall incidence rates of E. faecium, and E. faecalis bacteraemia, while KOL had a significantly higher incidence of VREfm (0.56 vs. 0.05 per 10,000 patient-d, p< .0001). There was a significant upward trend in VREfm bacteraemia cases (p= .01) and in the proportion of VREfm among bacteraemia caused by E. faecium (p= .027) at KOL, but such a trend was not observed at UMCG during the study period. Conclusions: The results reveal a significant difference in VREfm bacteraemia occurrences between a German and Dutch hospital in a cross-border region, reflecting national trends yet showing regional variation.http://www.sciencedirect.com/science/article/pii/S2213716525000578BacteraemiaEnterococcusVancomycin-resistant Enterococcus faeciumCross-border healthcareGermanythe Netherlands |
| spellingShingle | Cansu Cimen Andreas Voss Josef Hellkamp Axel Hamprecht Matthijs S. Berends Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemia in the northern Dutch-German cross-border region: A 10-y multicentre analysis (2013–2022) Journal of Global Antimicrobial Resistance Bacteraemia Enterococcus Vancomycin-resistant Enterococcus faecium Cross-border healthcare Germany the Netherlands |
| title | Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemia in the northern Dutch-German cross-border region: A 10-y multicentre analysis (2013–2022) |
| title_full | Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemia in the northern Dutch-German cross-border region: A 10-y multicentre analysis (2013–2022) |
| title_fullStr | Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemia in the northern Dutch-German cross-border region: A 10-y multicentre analysis (2013–2022) |
| title_full_unstemmed | Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemia in the northern Dutch-German cross-border region: A 10-y multicentre analysis (2013–2022) |
| title_short | Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemia in the northern Dutch-German cross-border region: A 10-y multicentre analysis (2013–2022) |
| title_sort | temporal trends of enterococcal and vancomycin resistant enterococcus faecium bacteraemia in the northern dutch german cross border region a 10 y multicentre analysis 2013 2022 |
| topic | Bacteraemia Enterococcus Vancomycin-resistant Enterococcus faecium Cross-border healthcare Germany the Netherlands |
| url | http://www.sciencedirect.com/science/article/pii/S2213716525000578 |
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