An Oxygenated Layer Coating to Enhance the Healing Process of Non-Healing Wounds—A Case Report
The ever-increasing problem of chronic, non-healing wound treatment is a challenge in contemporary medicine. This study aims to verify the effect of a designed dressing containing a coating involving oxygenating factors on the promotion of wound healing in all healing phases in a single clinical cas...
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MDPI AG
2024-12-01
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| Online Access: | https://www.mdpi.com/2076-3417/14/23/11200 |
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| author | Tomasz Miłek Anna Grzeczkowicz Agata Lipko Maria Mesjasz Leszek Oklesiński Angelika Kwiatkowska Marcin Strawski Monika Drabik Ludomira H. Granicka |
| author_facet | Tomasz Miłek Anna Grzeczkowicz Agata Lipko Maria Mesjasz Leszek Oklesiński Angelika Kwiatkowska Marcin Strawski Monika Drabik Ludomira H. Granicka |
| author_sort | Tomasz Miłek |
| collection | DOAJ |
| description | The ever-increasing problem of chronic, non-healing wound treatment is a challenge in contemporary medicine. This study aims to verify the effect of a designed dressing containing a coating involving oxygenating factors on the promotion of wound healing in all healing phases in a single clinical case. An alginate-based coating, which incorporates the oxygenating factor, was produced. The obtained surface physicochemical features were examined using FTIR and AFM. The bandage support was modified with the developed coating and applied to patients who suffered from chronic wounds (treated with non-modified commercially available bandages) and had required treatment at least 3 months before starting the study. During bandage application, the chosen characteristics of the wound-healing process were examined. A histological evaluation of granulation tissue confirmed the presence of fibroblasts, hemorrhage, and lymphocytes during the second week of treatment. Moreover, epithelization tissue in the third week of treatment exhibited the presence of keratinocytes. A 100% wound reduction was observed between 3 and 4 weeks of treatment with the modified dressing. It can be recommended that the applied coating, which provides a supportive effect through oxygenating elements, inducing the remodeling phase in up to 4 weeks of treatment, be developed for use in hard-to-heal wound treatment. |
| format | Article |
| id | doaj-art-a8f77413073942059262cb91c4cc7c5e |
| institution | OA Journals |
| issn | 2076-3417 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-a8f77413073942059262cb91c4cc7c5e2025-08-20T02:38:46ZengMDPI AGApplied Sciences2076-34172024-12-0114231120010.3390/app142311200An Oxygenated Layer Coating to Enhance the Healing Process of Non-Healing Wounds—A Case ReportTomasz Miłek0Anna Grzeczkowicz1Agata Lipko2Maria Mesjasz3Leszek Oklesiński4Angelika Kwiatkowska5Marcin Strawski6Monika Drabik7Ludomira H. Granicka8Faculty of Medicine, Lazarski University, Świeradowska 43 St., 02-662 Warsaw, PolandNalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Trojdena 4 St., 02-109 Warsaw, PolandNalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Trojdena 4 St., 02-109 Warsaw, PolandWolski Hospital, Marcina Kasprzaka 17 St., 01-211 Warsaw, PolandWolski Hospital, Marcina Kasprzaka 17 St., 01-211 Warsaw, PolandNalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Trojdena 4 St., 02-109 Warsaw, PolandLaboratory of Electrochemistry, Faculty of Chemistry, University of Warsaw, 00-927 Warsaw, PolandNalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Trojdena 4 St., 02-109 Warsaw, PolandNalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Trojdena 4 St., 02-109 Warsaw, PolandThe ever-increasing problem of chronic, non-healing wound treatment is a challenge in contemporary medicine. This study aims to verify the effect of a designed dressing containing a coating involving oxygenating factors on the promotion of wound healing in all healing phases in a single clinical case. An alginate-based coating, which incorporates the oxygenating factor, was produced. The obtained surface physicochemical features were examined using FTIR and AFM. The bandage support was modified with the developed coating and applied to patients who suffered from chronic wounds (treated with non-modified commercially available bandages) and had required treatment at least 3 months before starting the study. During bandage application, the chosen characteristics of the wound-healing process were examined. A histological evaluation of granulation tissue confirmed the presence of fibroblasts, hemorrhage, and lymphocytes during the second week of treatment. Moreover, epithelization tissue in the third week of treatment exhibited the presence of keratinocytes. A 100% wound reduction was observed between 3 and 4 weeks of treatment with the modified dressing. It can be recommended that the applied coating, which provides a supportive effect through oxygenating elements, inducing the remodeling phase in up to 4 weeks of treatment, be developed for use in hard-to-heal wound treatment.https://www.mdpi.com/2076-3417/14/23/11200polyelectrolyte coatingoxygenating factorplatelet-rich plasmadressingnon-healing woundgranulation |
| spellingShingle | Tomasz Miłek Anna Grzeczkowicz Agata Lipko Maria Mesjasz Leszek Oklesiński Angelika Kwiatkowska Marcin Strawski Monika Drabik Ludomira H. Granicka An Oxygenated Layer Coating to Enhance the Healing Process of Non-Healing Wounds—A Case Report Applied Sciences polyelectrolyte coating oxygenating factor platelet-rich plasma dressing non-healing wound granulation |
| title | An Oxygenated Layer Coating to Enhance the Healing Process of Non-Healing Wounds—A Case Report |
| title_full | An Oxygenated Layer Coating to Enhance the Healing Process of Non-Healing Wounds—A Case Report |
| title_fullStr | An Oxygenated Layer Coating to Enhance the Healing Process of Non-Healing Wounds—A Case Report |
| title_full_unstemmed | An Oxygenated Layer Coating to Enhance the Healing Process of Non-Healing Wounds—A Case Report |
| title_short | An Oxygenated Layer Coating to Enhance the Healing Process of Non-Healing Wounds—A Case Report |
| title_sort | oxygenated layer coating to enhance the healing process of non healing wounds a case report |
| topic | polyelectrolyte coating oxygenating factor platelet-rich plasma dressing non-healing wound granulation |
| url | https://www.mdpi.com/2076-3417/14/23/11200 |
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