Enhancing nonlinear transcriptome- and proteome-wide association studies via trait imputation with applications to Alzheimer's disease.

Genome-wide association studies (GWAS) performed on large cohort and biobank datasets have identified many genetic loci associated with Alzheimer's disease (AD). However, the younger demographic of biobank participants relative to the typical age of late-onset AD has resulted in an insufficient...

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Bibliographic Details
Main Authors: Ruoyu He, Jingchen Ren, Mykhaylo M Malakhov, Wei Pan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-04-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011659
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