H2S‐Activated Near‐Infrared Emission Chemiluminescent Probes for Precise Diagnosis of Inflammations and Tumors
ABSTRACT Compared to fluorescence imaging, chemiluminescence imaging does not need external excitation light, and hence presents high imaging depth and signal‐to‐noise ratio without autofluorescence and phototoxicity, making it a promising tool for biological detection and analysis. However, the tar...
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Wiley
2025-04-01
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| Online Access: | https://doi.org/10.1002/agt2.742 |
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| author | Mengke Liang Ling'e Zhang Bo Yu Zirui Geng Huazhen Ge Ying Sun Luyu Liu Xiqun Jiang Wei Wu |
| author_facet | Mengke Liang Ling'e Zhang Bo Yu Zirui Geng Huazhen Ge Ying Sun Luyu Liu Xiqun Jiang Wei Wu |
| author_sort | Mengke Liang |
| collection | DOAJ |
| description | ABSTRACT Compared to fluorescence imaging, chemiluminescence imaging does not need external excitation light, and hence presents high imaging depth and signal‐to‐noise ratio without autofluorescence and phototoxicity, making it a promising tool for biological detection and analysis. However, the target‐specific activatable near‐infrared emission chemiluminescent probes still need to be developed for the precise diagnosis of diseases. In this paper, we synthesized four direct near‐infrared emission Schaap's chemiluminophores (AINCL, AIFCL, ABTCL, and APYCL) by incorporating different electronic acceptors, respectively, and studied the effect of the acceptors on the optical properties of the chemiluminophores. To achieve the specific detection of hydrogen sulfide (H2S)‐related diseases, we used H2S‐cleavable 2,4‐dinitrophenylsulfonate to cage the phenol groups in the chemiluminophores. It was demonstrated that the endogenous H2S in inflammations and tumors could activate effectively the chemiluminescence with high specificity, which provided the precise location of nidus in chemiluminescence imaging and allowed us to perform surgical resection. |
| format | Article |
| id | doaj-art-a8e9c66faf264ee98e8a62966e15c4c7 |
| institution | OA Journals |
| issn | 2692-4560 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
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| spelling | doaj-art-a8e9c66faf264ee98e8a62966e15c4c72025-08-20T02:11:51ZengWileyAggregate2692-45602025-04-0164n/an/a10.1002/agt2.742H2S‐Activated Near‐Infrared Emission Chemiluminescent Probes for Precise Diagnosis of Inflammations and TumorsMengke Liang0Ling'e Zhang1Bo Yu2Zirui Geng3Huazhen Ge4Ying Sun5Luyu Liu6Xiqun Jiang7Wei Wu8Department of Polymer Science & Engineering, State Key Laboratory of Analytical Chemistry for Life Science, College of Chemistry & Chemical Engineering Nanjing University Nanjing PR ChinaDepartment of Polymer Science & Engineering, State Key Laboratory of Analytical Chemistry for Life Science, College of Chemistry & Chemical Engineering Nanjing University Nanjing PR ChinaDepartment of Polymer Science & Engineering, State Key Laboratory of Analytical Chemistry for Life Science, College of Chemistry & Chemical Engineering Nanjing University Nanjing PR ChinaDepartment of Polymer Science & Engineering, State Key Laboratory of Analytical Chemistry for Life Science, College of Chemistry & Chemical Engineering Nanjing University Nanjing PR ChinaDepartment of Polymer Science & Engineering, State Key Laboratory of Analytical Chemistry for Life Science, College of Chemistry & Chemical Engineering Nanjing University Nanjing PR ChinaDepartment of Polymer Science & Engineering, State Key Laboratory of Analytical Chemistry for Life Science, College of Chemistry & Chemical Engineering Nanjing University Nanjing PR ChinaDepartment of Polymer Science & Engineering, State Key Laboratory of Analytical Chemistry for Life Science, College of Chemistry & Chemical Engineering Nanjing University Nanjing PR ChinaDepartment of Polymer Science & Engineering, State Key Laboratory of Analytical Chemistry for Life Science, College of Chemistry & Chemical Engineering Nanjing University Nanjing PR ChinaDepartment of Polymer Science & Engineering, State Key Laboratory of Analytical Chemistry for Life Science, College of Chemistry & Chemical Engineering Nanjing University Nanjing PR ChinaABSTRACT Compared to fluorescence imaging, chemiluminescence imaging does not need external excitation light, and hence presents high imaging depth and signal‐to‐noise ratio without autofluorescence and phototoxicity, making it a promising tool for biological detection and analysis. However, the target‐specific activatable near‐infrared emission chemiluminescent probes still need to be developed for the precise diagnosis of diseases. In this paper, we synthesized four direct near‐infrared emission Schaap's chemiluminophores (AINCL, AIFCL, ABTCL, and APYCL) by incorporating different electronic acceptors, respectively, and studied the effect of the acceptors on the optical properties of the chemiluminophores. To achieve the specific detection of hydrogen sulfide (H2S)‐related diseases, we used H2S‐cleavable 2,4‐dinitrophenylsulfonate to cage the phenol groups in the chemiluminophores. It was demonstrated that the endogenous H2S in inflammations and tumors could activate effectively the chemiluminescence with high specificity, which provided the precise location of nidus in chemiluminescence imaging and allowed us to perform surgical resection.https://doi.org/10.1002/agt2.742Schaap’s chemiluminophoresdirect near‐infrared emissionchemiluminescence imaginginflammationstumors |
| spellingShingle | Mengke Liang Ling'e Zhang Bo Yu Zirui Geng Huazhen Ge Ying Sun Luyu Liu Xiqun Jiang Wei Wu H2S‐Activated Near‐Infrared Emission Chemiluminescent Probes for Precise Diagnosis of Inflammations and Tumors Aggregate Schaap’s chemiluminophores direct near‐infrared emission chemiluminescence imaging inflammations tumors |
| title | H2S‐Activated Near‐Infrared Emission Chemiluminescent Probes for Precise Diagnosis of Inflammations and Tumors |
| title_full | H2S‐Activated Near‐Infrared Emission Chemiluminescent Probes for Precise Diagnosis of Inflammations and Tumors |
| title_fullStr | H2S‐Activated Near‐Infrared Emission Chemiluminescent Probes for Precise Diagnosis of Inflammations and Tumors |
| title_full_unstemmed | H2S‐Activated Near‐Infrared Emission Chemiluminescent Probes for Precise Diagnosis of Inflammations and Tumors |
| title_short | H2S‐Activated Near‐Infrared Emission Chemiluminescent Probes for Precise Diagnosis of Inflammations and Tumors |
| title_sort | h2s activated near infrared emission chemiluminescent probes for precise diagnosis of inflammations and tumors |
| topic | Schaap’s chemiluminophores direct near‐infrared emission chemiluminescence imaging inflammations tumors |
| url | https://doi.org/10.1002/agt2.742 |
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