Reproducible extracellular matrices for tumor organoid culture: challenges and opportunities

Reproducible extracellular matrices for tumor organoid culture: challenges and opportunities

Abstract Tumor organoid models have emerged as valuable 3D in vitro systems to study cancer behavior in a physiologically relevant environment. The composition and architecture of the extracellular matrix (ECM) play critical roles in tumor organoid culture by influencing the tumor microenvironment a...

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Bibliographic Details
Main Authors: Kan Li, Yibo He, Xue Jin, Ketao Jin, Jun Qian
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Extracellular matrix
Reproducibility
Tumor microenvironment
Tumor organoid
Tunability
Online Access:https://doi.org/10.1186/s12967-025-06349-x
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