Efficacy of Asymmetric Myopic Peripheral Defocus Lenses in Spanish Children: 24-Month Randomized Clinical Trial Results
<b>Background/Objectives</b>: Asymmetric myopic peripheral defocus lenses (MPDLs) have proven to be effective in slowing the progression of myopia in Spanish children over a period of 12 months. The purpose of this study was to assess the MPDL spectacles’ efficacy in slowing myopia progr...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-02-01
|
| Series: | Children |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9067/12/2/191 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850082221650608128 |
|---|---|
| author | Clara Martinez-Perez Miguel Ángel Sánchez-Tena Jose Miguel Cleva Cesar Villa-Collar Marta Álvarez Eva Chamorro Cristina Alvarez-Peregrina |
| author_facet | Clara Martinez-Perez Miguel Ángel Sánchez-Tena Jose Miguel Cleva Cesar Villa-Collar Marta Álvarez Eva Chamorro Cristina Alvarez-Peregrina |
| author_sort | Clara Martinez-Perez |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Asymmetric myopic peripheral defocus lenses (MPDLs) have proven to be effective in slowing the progression of myopia in Spanish children over a period of 12 months. The purpose of this study was to assess the MPDL spectacles’ efficacy in slowing myopia progression over a 24-month period in children. <b>Methods</b>: This study extends the follow-up period of the double-masked, prospective, and randomized clinical trial previously published to 24 months. Children from 6 to 12 years were assigned to two groups: a control group wearing spherotorical single vision lenses (SVLs) or a treatment group wearing MPDL lenses. Inclusion criteria included children with myopia less than −0.50 D, astigmatism below 1.50 D, and best-corrected visual acuity of at least 20/20. Participants underwent cycloplegic autorefractive examination and axial length (AL) measurements at the baseline and six and twelve months in the study already published, and twenty-four months later in the present study. Lifestyle factors, including outdoor activities and digital device use, were also assessed. Baseline characteristics, including age, refractive error, and AL, were comparable between groups. Dropout rates were 15.9%, with 14 participants lost to follow-up, distributed equally between the two groups. <b>Results</b>: After 24 months of follow-up, 69 children remained in this study, comprising 34 participants in the SVL cohort and 35 in the MPDL cohort. Over 24 months, the MPDL group showed significantly less AL elongation than the SVL group (0.27 ± 0.23 mm and 0.37 ± 0.24 mm; <i>p</i> = 0.0341). The mean relative AL increase was 1.10 ± 0.95% in the MPDL group, compared to 1.56 ± 1.02% in the SVL group (<i>p</i> = 0.0322). Younger children exhibited faster AL growth, while digital device use and outdoor activities did not affect AL changes. <b>Conclusions</b>: MPDL spectacle lenses substantially slowed myopia progression over a 24-month period, with 28.7% less progression in absolute AL growth and 29.8% in relative AL growth compared to SVL. These results indicate that MPDL lenses are an effective method for slowing myopia progression. |
| format | Article |
| id | doaj-art-a8e85cabdd764fa2b07522ce64957fa3 |
| institution | DOAJ |
| issn | 2227-9067 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj-art-a8e85cabdd764fa2b07522ce64957fa32025-08-20T02:44:34ZengMDPI AGChildren2227-90672025-02-0112219110.3390/children12020191Efficacy of Asymmetric Myopic Peripheral Defocus Lenses in Spanish Children: 24-Month Randomized Clinical Trial ResultsClara Martinez-Perez0Miguel Ángel Sánchez-Tena1Jose Miguel Cleva2Cesar Villa-Collar3Marta Álvarez4Eva Chamorro5Cristina Alvarez-Peregrina6School of Management, Engineering and Aeronautics, ISEC LISBOA—Instituto Superior de Educação e Ciências, Alameda das Linhas de Torres, 179, 1750-142 Lisbon, PortugalSchool of Management, Engineering and Aeronautics, ISEC LISBOA—Instituto Superior de Educação e Ciências, Alameda das Linhas de Torres, 179, 1750-142 Lisbon, PortugalClinical Research Department, Indizen Optical Technologies, 28002 Madrid, SpainFaculty of Biomedical and Health Science, Universidad Europea de Madrid, 28670 Madrid, SpainClinical Research Department, Indizen Optical Technologies, 28002 Madrid, SpainClinical Research Department, Indizen Optical Technologies, 28002 Madrid, SpainDepartment of Optometry and Vision, Faculty of Optics and Optometry, Universidad Complutense de Madrid, 28037 Madrid, Spain<b>Background/Objectives</b>: Asymmetric myopic peripheral defocus lenses (MPDLs) have proven to be effective in slowing the progression of myopia in Spanish children over a period of 12 months. The purpose of this study was to assess the MPDL spectacles’ efficacy in slowing myopia progression over a 24-month period in children. <b>Methods</b>: This study extends the follow-up period of the double-masked, prospective, and randomized clinical trial previously published to 24 months. Children from 6 to 12 years were assigned to two groups: a control group wearing spherotorical single vision lenses (SVLs) or a treatment group wearing MPDL lenses. Inclusion criteria included children with myopia less than −0.50 D, astigmatism below 1.50 D, and best-corrected visual acuity of at least 20/20. Participants underwent cycloplegic autorefractive examination and axial length (AL) measurements at the baseline and six and twelve months in the study already published, and twenty-four months later in the present study. Lifestyle factors, including outdoor activities and digital device use, were also assessed. Baseline characteristics, including age, refractive error, and AL, were comparable between groups. Dropout rates were 15.9%, with 14 participants lost to follow-up, distributed equally between the two groups. <b>Results</b>: After 24 months of follow-up, 69 children remained in this study, comprising 34 participants in the SVL cohort and 35 in the MPDL cohort. Over 24 months, the MPDL group showed significantly less AL elongation than the SVL group (0.27 ± 0.23 mm and 0.37 ± 0.24 mm; <i>p</i> = 0.0341). The mean relative AL increase was 1.10 ± 0.95% in the MPDL group, compared to 1.56 ± 1.02% in the SVL group (<i>p</i> = 0.0322). Younger children exhibited faster AL growth, while digital device use and outdoor activities did not affect AL changes. <b>Conclusions</b>: MPDL spectacle lenses substantially slowed myopia progression over a 24-month period, with 28.7% less progression in absolute AL growth and 29.8% in relative AL growth compared to SVL. These results indicate that MPDL lenses are an effective method for slowing myopia progression.https://www.mdpi.com/2227-9067/12/2/191myopiaaxial lengthspectacle lenses |
| spellingShingle | Clara Martinez-Perez Miguel Ángel Sánchez-Tena Jose Miguel Cleva Cesar Villa-Collar Marta Álvarez Eva Chamorro Cristina Alvarez-Peregrina Efficacy of Asymmetric Myopic Peripheral Defocus Lenses in Spanish Children: 24-Month Randomized Clinical Trial Results Children myopia axial length spectacle lenses |
| title | Efficacy of Asymmetric Myopic Peripheral Defocus Lenses in Spanish Children: 24-Month Randomized Clinical Trial Results |
| title_full | Efficacy of Asymmetric Myopic Peripheral Defocus Lenses in Spanish Children: 24-Month Randomized Clinical Trial Results |
| title_fullStr | Efficacy of Asymmetric Myopic Peripheral Defocus Lenses in Spanish Children: 24-Month Randomized Clinical Trial Results |
| title_full_unstemmed | Efficacy of Asymmetric Myopic Peripheral Defocus Lenses in Spanish Children: 24-Month Randomized Clinical Trial Results |
| title_short | Efficacy of Asymmetric Myopic Peripheral Defocus Lenses in Spanish Children: 24-Month Randomized Clinical Trial Results |
| title_sort | efficacy of asymmetric myopic peripheral defocus lenses in spanish children 24 month randomized clinical trial results |
| topic | myopia axial length spectacle lenses |
| url | https://www.mdpi.com/2227-9067/12/2/191 |
| work_keys_str_mv | AT claramartinezperez efficacyofasymmetricmyopicperipheraldefocuslensesinspanishchildren24monthrandomizedclinicaltrialresults AT miguelangelsancheztena efficacyofasymmetricmyopicperipheraldefocuslensesinspanishchildren24monthrandomizedclinicaltrialresults AT josemiguelcleva efficacyofasymmetricmyopicperipheraldefocuslensesinspanishchildren24monthrandomizedclinicaltrialresults AT cesarvillacollar efficacyofasymmetricmyopicperipheraldefocuslensesinspanishchildren24monthrandomizedclinicaltrialresults AT martaalvarez efficacyofasymmetricmyopicperipheraldefocuslensesinspanishchildren24monthrandomizedclinicaltrialresults AT evachamorro efficacyofasymmetricmyopicperipheraldefocuslensesinspanishchildren24monthrandomizedclinicaltrialresults AT cristinaalvarezperegrina efficacyofasymmetricmyopicperipheraldefocuslensesinspanishchildren24monthrandomizedclinicaltrialresults |