Desmoid-type fibromatosis of the breast: a case report and literature review
Breast desmoid-type fibromatosis (BDF) is a rare tumor predominated by mesenchymal cells. It has a high recurrence rate, although distal metastasis is uncommon. It resembles breast cancer clinically, and histological pathology is the only approach to a confirmed diagnosis. Comprehensive and individu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1482024/full |
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| author | Zijun Zhao Qingyao Shang Chenxuan Yang Jiaxiang Liu Shanqing Liu Xiaoqian Li Xiyu Kang Jiaxian Yue Xin Wang Xiang Wang |
| author_facet | Zijun Zhao Qingyao Shang Chenxuan Yang Jiaxiang Liu Shanqing Liu Xiaoqian Li Xiyu Kang Jiaxian Yue Xin Wang Xiang Wang |
| author_sort | Zijun Zhao |
| collection | DOAJ |
| description | Breast desmoid-type fibromatosis (BDF) is a rare tumor predominated by mesenchymal cells. It has a high recurrence rate, although distal metastasis is uncommon. It resembles breast cancer clinically, and histological pathology is the only approach to a confirmed diagnosis. Comprehensive and individualized treatments were recommended for BDF patients. Here, we presented a case of BDF secondary to primary breast carcinoma in our center. A 47-year-old female complained of a large mass in her left breast for 2.5 months. She has a past history of left breast carcinoma with a failure of surgical and systemic intervention. Despite an active re-operation, she still suffered from disease progression with a bad prognosis. After our report, the clinicopathological traits, differential diagnosis of BDF and current recommendation of management were discussed. This case report aimed to make a clear recognition of this rare and aggressive disease and elaborate up-to-date treatment recommendations. More effective drugs and larger sample clinical studies are encouraged for better management of refractory and progressive BDF. |
| format | Article |
| id | doaj-art-a8e1f27eeaf54401b1b473e232cff2f5 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-a8e1f27eeaf54401b1b473e232cff2f52025-02-11T06:59:36ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.14820241482024Desmoid-type fibromatosis of the breast: a case report and literature reviewZijun Zhao0Qingyao Shang1Chenxuan Yang2Jiaxiang Liu3Shanqing Liu4Xiaoqian Li5Xiyu Kang6Jiaxian Yue7Xin Wang8Xiang Wang9Department of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Breast Disease, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, ChinaDepartment of General Surgery, Beijing Huairou Teaching Hospital, Capital Medical University, Beijing, ChinaDepartment of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaBreast desmoid-type fibromatosis (BDF) is a rare tumor predominated by mesenchymal cells. It has a high recurrence rate, although distal metastasis is uncommon. It resembles breast cancer clinically, and histological pathology is the only approach to a confirmed diagnosis. Comprehensive and individualized treatments were recommended for BDF patients. Here, we presented a case of BDF secondary to primary breast carcinoma in our center. A 47-year-old female complained of a large mass in her left breast for 2.5 months. She has a past history of left breast carcinoma with a failure of surgical and systemic intervention. Despite an active re-operation, she still suffered from disease progression with a bad prognosis. After our report, the clinicopathological traits, differential diagnosis of BDF and current recommendation of management were discussed. This case report aimed to make a clear recognition of this rare and aggressive disease and elaborate up-to-date treatment recommendations. More effective drugs and larger sample clinical studies are encouraged for better management of refractory and progressive BDF.https://www.frontiersin.org/articles/10.3389/fonc.2025.1482024/fulldesmoid-type fibromatosisbreastcase reportpathologytreatment |
| spellingShingle | Zijun Zhao Qingyao Shang Chenxuan Yang Jiaxiang Liu Shanqing Liu Xiaoqian Li Xiyu Kang Jiaxian Yue Xin Wang Xiang Wang Desmoid-type fibromatosis of the breast: a case report and literature review Frontiers in Oncology desmoid-type fibromatosis breast case report pathology treatment |
| title | Desmoid-type fibromatosis of the breast: a case report and literature review |
| title_full | Desmoid-type fibromatosis of the breast: a case report and literature review |
| title_fullStr | Desmoid-type fibromatosis of the breast: a case report and literature review |
| title_full_unstemmed | Desmoid-type fibromatosis of the breast: a case report and literature review |
| title_short | Desmoid-type fibromatosis of the breast: a case report and literature review |
| title_sort | desmoid type fibromatosis of the breast a case report and literature review |
| topic | desmoid-type fibromatosis breast case report pathology treatment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1482024/full |
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