Successful Complete Response of Tumor Thrombus after Combined with Chemotherapy and Irradiation for Ewing Sarcoma
Pelvic Ewing sarcoma is associated with a worse prognosis. Thromboembolic events are relatively common in pediatric patients with cancers including sarcomas. We have presented a case of Ewing sarcoma arising from the left iliac bone with tumor thrombus of inferior vena cava (IVC) which was obtained...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Orthopedics |
| Online Access: | http://dx.doi.org/10.1155/2018/5238512 |
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| author | Yusuke Minami Seiichi Matsumoto Keisuke Ae Taisuke Tanizawa Keiko Hayakawa Yuki Funauchi Sakae Okumura Yutaka Takazawa |
| author_facet | Yusuke Minami Seiichi Matsumoto Keisuke Ae Taisuke Tanizawa Keiko Hayakawa Yuki Funauchi Sakae Okumura Yutaka Takazawa |
| author_sort | Yusuke Minami |
| collection | DOAJ |
| description | Pelvic Ewing sarcoma is associated with a worse prognosis. Thromboembolic events are relatively common in pediatric patients with cancers including sarcomas. We have presented a case of Ewing sarcoma arising from the left iliac bone with tumor thrombus of inferior vena cava (IVC) which was obtained complete response by both chemotherapy and irradiation. Magnetic resonance imaging (MRI) scan demonstrated that the tumor arising from the left iliac bone extended into the left side of sacral bone, suggesting the difficulty of surgical resection. Computed tomography (CT) revealed the existence of the tumor thrombus of IVC. We performed irradiation (31.2 Gy) and chemotherapy (combination of VCR, Act-D, IFM, and ADR). The tumor was controlled successfully, and the tumor thrombus of IVC has completely vanished. Four years after the treatment, coin lesion in the left upper lung appeared. Suspected of metastasis, segmental resection of the left upper lung was performed. Fourteen years after the surgery, the patient has been remained free of recurrence. It is clinically significant for surgeons to treat pelvic Ewing sarcoma with tumor thrombus. |
| format | Article |
| id | doaj-art-a8ddf445954b421a871ad735689ded6d |
| institution | Kabale University |
| issn | 2090-6749 2090-6757 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Orthopedics |
| spelling | doaj-art-a8ddf445954b421a871ad735689ded6d2025-08-20T03:39:09ZengWileyCase Reports in Orthopedics2090-67492090-67572018-01-01201810.1155/2018/52385125238512Successful Complete Response of Tumor Thrombus after Combined with Chemotherapy and Irradiation for Ewing SarcomaYusuke Minami0Seiichi Matsumoto1Keisuke Ae2Taisuke Tanizawa3Keiko Hayakawa4Yuki Funauchi5Sakae Okumura6Yutaka Takazawa7Department of Orthopedic Surgery, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, JapanDepartment of Orthopedic Surgery, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, JapanDepartment of Orthopedic Surgery, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, JapanDepartment of Orthopedic Surgery, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, JapanDepartment of Orthopedic Surgery, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, JapanDepartment of Orthopedic Surgery, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, JapanDepartment of Thoracic Surgery, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, JapanDepartment of Pathology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, JapanPelvic Ewing sarcoma is associated with a worse prognosis. Thromboembolic events are relatively common in pediatric patients with cancers including sarcomas. We have presented a case of Ewing sarcoma arising from the left iliac bone with tumor thrombus of inferior vena cava (IVC) which was obtained complete response by both chemotherapy and irradiation. Magnetic resonance imaging (MRI) scan demonstrated that the tumor arising from the left iliac bone extended into the left side of sacral bone, suggesting the difficulty of surgical resection. Computed tomography (CT) revealed the existence of the tumor thrombus of IVC. We performed irradiation (31.2 Gy) and chemotherapy (combination of VCR, Act-D, IFM, and ADR). The tumor was controlled successfully, and the tumor thrombus of IVC has completely vanished. Four years after the treatment, coin lesion in the left upper lung appeared. Suspected of metastasis, segmental resection of the left upper lung was performed. Fourteen years after the surgery, the patient has been remained free of recurrence. It is clinically significant for surgeons to treat pelvic Ewing sarcoma with tumor thrombus.http://dx.doi.org/10.1155/2018/5238512 |
| spellingShingle | Yusuke Minami Seiichi Matsumoto Keisuke Ae Taisuke Tanizawa Keiko Hayakawa Yuki Funauchi Sakae Okumura Yutaka Takazawa Successful Complete Response of Tumor Thrombus after Combined with Chemotherapy and Irradiation for Ewing Sarcoma Case Reports in Orthopedics |
| title | Successful Complete Response of Tumor Thrombus after Combined with Chemotherapy and Irradiation for Ewing Sarcoma |
| title_full | Successful Complete Response of Tumor Thrombus after Combined with Chemotherapy and Irradiation for Ewing Sarcoma |
| title_fullStr | Successful Complete Response of Tumor Thrombus after Combined with Chemotherapy and Irradiation for Ewing Sarcoma |
| title_full_unstemmed | Successful Complete Response of Tumor Thrombus after Combined with Chemotherapy and Irradiation for Ewing Sarcoma |
| title_short | Successful Complete Response of Tumor Thrombus after Combined with Chemotherapy and Irradiation for Ewing Sarcoma |
| title_sort | successful complete response of tumor thrombus after combined with chemotherapy and irradiation for ewing sarcoma |
| url | http://dx.doi.org/10.1155/2018/5238512 |
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