Dynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5–12 Weeks of Gestation
Fetal stem cell- (FSC-) based therapy is a promising treatment option for many diseases. The differentiation potential of FSCs is greater than that in adult stem cells, and they are more tissue-specific and have lower immunogenicity and better intrinsic homing than embryonic ones. Embryonic stem cel...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/1385903 |
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| author | Khrystyna Sorochynska Nataliia Sych Alla Duda Kateryna Kulebyakina Dmytro Krasnienkov Alexander Vaiserman Denys Vatlitsov |
| author_facet | Khrystyna Sorochynska Nataliia Sych Alla Duda Kateryna Kulebyakina Dmytro Krasnienkov Alexander Vaiserman Denys Vatlitsov |
| author_sort | Khrystyna Sorochynska |
| collection | DOAJ |
| description | Fetal stem cell- (FSC-) based therapy is a promising treatment option for many diseases. The differentiation potential of FSCs is greater than that in adult stem cells, and they are more tissue-specific and have lower immunogenicity and better intrinsic homing than embryonic ones. Embryonic stem cells have higher proliferative potential than FSCs but can cause teratomas. Therefore, an evaluation of this potential represents an important biomedical challenge. Since regulation of telomere length (TL) is one mechanism governing cellular proliferation, TL is a useful surrogate marker for cell replicative potential. The prenatal dynamics of TL, however, has never been comprehensively studied. In the present study, dynamics of TL and telomerase activity in the human fetal liver during 5–12 weeks of gestation is examined. Both TL and telomerase activity were positively correlated with week of gestation. For both parameters studied, the trend to increase was evident up to 10th week of gestation. After that, they reached a plateau and remained stable. These findings indicate that telomerase activity remains high during the fetal stage, suggesting high replicative capacity of FSCs and their considerable potential for transplantation therapies. These findings, however, are preliminary only due to small sample size and require further evaluation. |
| format | Article |
| id | doaj-art-a8d92304d13e41a2bf49d455b8b9aeea |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-a8d92304d13e41a2bf49d455b8b9aeea2025-08-20T02:20:44ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/13859031385903Dynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5–12 Weeks of GestationKhrystyna Sorochynska0Nataliia Sych1Alla Duda2Kateryna Kulebyakina3Dmytro Krasnienkov4Alexander Vaiserman5Denys Vatlitsov6Laboratory Department, Cell Therapy Center EmCell, 37A Syretska Str., Kiev 04073, UkraineClinical Department, Cell Therapy Center EmCell, 37A Syretska Str., Kiev 04073, UkraineLaboratory Department, Cell Therapy Center EmCell, 37A Syretska Str., Kiev 04073, UkraineLaboratory Department, Cell Therapy Center EmCell, 37A Syretska Str., Kiev 04073, UkraineInstitute of Gerontology, NAMS of Ukraine, 67 Vyshgorodska Str., Kiev 04114, UkraineInstitute of Gerontology, NAMS of Ukraine, 67 Vyshgorodska Str., Kiev 04114, UkraineLaboratory Department, Cell Therapy Center EmCell, 37A Syretska Str., Kiev 04073, UkraineFetal stem cell- (FSC-) based therapy is a promising treatment option for many diseases. The differentiation potential of FSCs is greater than that in adult stem cells, and they are more tissue-specific and have lower immunogenicity and better intrinsic homing than embryonic ones. Embryonic stem cells have higher proliferative potential than FSCs but can cause teratomas. Therefore, an evaluation of this potential represents an important biomedical challenge. Since regulation of telomere length (TL) is one mechanism governing cellular proliferation, TL is a useful surrogate marker for cell replicative potential. The prenatal dynamics of TL, however, has never been comprehensively studied. In the present study, dynamics of TL and telomerase activity in the human fetal liver during 5–12 weeks of gestation is examined. Both TL and telomerase activity were positively correlated with week of gestation. For both parameters studied, the trend to increase was evident up to 10th week of gestation. After that, they reached a plateau and remained stable. These findings indicate that telomerase activity remains high during the fetal stage, suggesting high replicative capacity of FSCs and their considerable potential for transplantation therapies. These findings, however, are preliminary only due to small sample size and require further evaluation.http://dx.doi.org/10.1155/2018/1385903 |
| spellingShingle | Khrystyna Sorochynska Nataliia Sych Alla Duda Kateryna Kulebyakina Dmytro Krasnienkov Alexander Vaiserman Denys Vatlitsov Dynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5–12 Weeks of Gestation Stem Cells International |
| title | Dynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5–12 Weeks of Gestation |
| title_full | Dynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5–12 Weeks of Gestation |
| title_fullStr | Dynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5–12 Weeks of Gestation |
| title_full_unstemmed | Dynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5–12 Weeks of Gestation |
| title_short | Dynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5–12 Weeks of Gestation |
| title_sort | dynamics of telomere length and telomerase activity in the human fetal liver at 5 12 weeks of gestation |
| url | http://dx.doi.org/10.1155/2018/1385903 |
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