Effect of golimumab on endothelial vasomotor function and arterial stiffness in ankylosing spondylitis
Objective: to evaluate the effect of golimumab (GLM) on endothelial vasomotor function and arterial stiffness in patients with ankylosing spondylitis (AS).Subjects and methods. A total of 42 patients with advanced-stage AS, who were older than 18 years and met the 1984 modified New York criteria wit...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA PRESS LLC
2019-07-01
|
| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2732 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849687883612422144 |
|---|---|
| author | L. A. Knyazeva N. Damjanov L. I. Knyazeva N. S. Meshcherina I. I. Goryainov M. A. Stepchenko Ya. I. Bobyntsev O. S. Rudakov |
| author_facet | L. A. Knyazeva N. Damjanov L. I. Knyazeva N. S. Meshcherina I. I. Goryainov M. A. Stepchenko Ya. I. Bobyntsev O. S. Rudakov |
| author_sort | L. A. Knyazeva |
| collection | DOAJ |
| description | Objective: to evaluate the effect of golimumab (GLM) on endothelial vasomotor function and arterial stiffness in patients with ankylosing spondylitis (AS).Subjects and methods. A total of 42 patients with advanced-stage AS, who were older than 18 years and met the 1984 modified New York criteria with a disease duration of ≤5 years, were examined. The investigators visualized carotid arteries to determine local vascular wall stiffness, studied regional arterial stiffness to assess a pulse wave contour analysis, and a reactive hyperemia test before and after 104-week therapy.Results and discussion. RA patients without cardiovascular comorbidity were found to have signs of subclinical great artery involvement accompanied by endothelial vasoregulatory dysfunction in both the small resistance and large muscular arteries; by increases in common carotid artery (CCA) intima-media thickness (IMT) and stiffness index (SI); by rises in peripheral augmentation index (AIp), SI and reflection index (RI), the intensity of a change in which correlated with disease duration and activity assessed by ASDAS; as well as with the modified Schober test value, cervical rotation, and tragus-to-wall distance. In addition to a decrease in the Ankylosing Spondylitis Disease Activity Score (ASDAS), GML treatment in patients with AS caused a statistically significant increase in the amplitude occlusion index to the control values and a rise in the phase shift between the channels by an average of 2 times (p<0.01) as compared to the baseline values; a decrease in CCA IMT by an average by 20% (p=0.01) and in the local stiffness of the (carotid) vascular bed by 31% (p=0.01). The pulse wave contour analysis after 104-week GLM therapy revealed that AIp, SI and RI decreased by an average of 5 (р<0.001), 1.3 (р<0.01), and 2 (p<0.05) times, respectively, with the remaining statistically significant differences from the control values.Conclusion. In addition to the effectively reduced inflammatory activity, GLM therapy in patients with AS provides restoration of endothelial function in both the small resistance vessels (an increase in the amplitude occlusion index) and the large muscular arteries (a rise in the phase shift between the channels) and also has a vasoprotective effect on the wall of large elastic vessels (reductions in CCA IMT, SI, AIp, and SI) and small muscular arteries (a decrease in RI). |
| format | Article |
| id | doaj-art-a8d6e3d1cd944c719c40e58d666cfe41 |
| institution | DOAJ |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2019-07-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-a8d6e3d1cd944c719c40e58d666cfe412025-08-20T03:22:12ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922019-07-0157331231710.14412/1995-4484-2019-312-3172496Effect of golimumab on endothelial vasomotor function and arterial stiffness in ankylosing spondylitisL. A. Knyazeva0N. Damjanov1L. I. Knyazeva2N. S. Meshcherina3I. I. Goryainov4M. A. Stepchenko5Ya. I. Bobyntsev6O. S. Rudakov7Kursk State Medical University, Ministry of Health of RussiaDepartment of Internal Medicine, University of Belgrade, Institute of RheumatologyKursk State Medical University, Ministry of Health of RussiaKursk State Medical University, Ministry of Health of RussiaKursk State Medical University, Ministry of Health of RussiaKursk State Medical University, Ministry of Health of RussiaKursk State Medical University, Ministry of Health of RussiaKursk State Medical University, Ministry of Health of RussiaObjective: to evaluate the effect of golimumab (GLM) on endothelial vasomotor function and arterial stiffness in patients with ankylosing spondylitis (AS).Subjects and methods. A total of 42 patients with advanced-stage AS, who were older than 18 years and met the 1984 modified New York criteria with a disease duration of ≤5 years, were examined. The investigators visualized carotid arteries to determine local vascular wall stiffness, studied regional arterial stiffness to assess a pulse wave contour analysis, and a reactive hyperemia test before and after 104-week therapy.Results and discussion. RA patients without cardiovascular comorbidity were found to have signs of subclinical great artery involvement accompanied by endothelial vasoregulatory dysfunction in both the small resistance and large muscular arteries; by increases in common carotid artery (CCA) intima-media thickness (IMT) and stiffness index (SI); by rises in peripheral augmentation index (AIp), SI and reflection index (RI), the intensity of a change in which correlated with disease duration and activity assessed by ASDAS; as well as with the modified Schober test value, cervical rotation, and tragus-to-wall distance. In addition to a decrease in the Ankylosing Spondylitis Disease Activity Score (ASDAS), GML treatment in patients with AS caused a statistically significant increase in the amplitude occlusion index to the control values and a rise in the phase shift between the channels by an average of 2 times (p<0.01) as compared to the baseline values; a decrease in CCA IMT by an average by 20% (p=0.01) and in the local stiffness of the (carotid) vascular bed by 31% (p=0.01). The pulse wave contour analysis after 104-week GLM therapy revealed that AIp, SI and RI decreased by an average of 5 (р<0.001), 1.3 (р<0.01), and 2 (p<0.05) times, respectively, with the remaining statistically significant differences from the control values.Conclusion. In addition to the effectively reduced inflammatory activity, GLM therapy in patients with AS provides restoration of endothelial function in both the small resistance vessels (an increase in the amplitude occlusion index) and the large muscular arteries (a rise in the phase shift between the channels) and also has a vasoprotective effect on the wall of large elastic vessels (reductions in CCA IMT, SI, AIp, and SI) and small muscular arteries (a decrease in RI).https://rsp.mediar-press.net/rsp/article/view/2732ankylosing spondylitisarterial stiffnessgolimumabintima-media thicknesspulse wave contour analysisendothelial dysfunction |
| spellingShingle | L. A. Knyazeva N. Damjanov L. I. Knyazeva N. S. Meshcherina I. I. Goryainov M. A. Stepchenko Ya. I. Bobyntsev O. S. Rudakov Effect of golimumab on endothelial vasomotor function and arterial stiffness in ankylosing spondylitis Научно-практическая ревматология ankylosing spondylitis arterial stiffness golimumab intima-media thickness pulse wave contour analysis endothelial dysfunction |
| title | Effect of golimumab on endothelial vasomotor function and arterial stiffness in ankylosing spondylitis |
| title_full | Effect of golimumab on endothelial vasomotor function and arterial stiffness in ankylosing spondylitis |
| title_fullStr | Effect of golimumab on endothelial vasomotor function and arterial stiffness in ankylosing spondylitis |
| title_full_unstemmed | Effect of golimumab on endothelial vasomotor function and arterial stiffness in ankylosing spondylitis |
| title_short | Effect of golimumab on endothelial vasomotor function and arterial stiffness in ankylosing spondylitis |
| title_sort | effect of golimumab on endothelial vasomotor function and arterial stiffness in ankylosing spondylitis |
| topic | ankylosing spondylitis arterial stiffness golimumab intima-media thickness pulse wave contour analysis endothelial dysfunction |
| url | https://rsp.mediar-press.net/rsp/article/view/2732 |
| work_keys_str_mv | AT laknyazeva effectofgolimumabonendothelialvasomotorfunctionandarterialstiffnessinankylosingspondylitis AT ndamjanov effectofgolimumabonendothelialvasomotorfunctionandarterialstiffnessinankylosingspondylitis AT liknyazeva effectofgolimumabonendothelialvasomotorfunctionandarterialstiffnessinankylosingspondylitis AT nsmeshcherina effectofgolimumabonendothelialvasomotorfunctionandarterialstiffnessinankylosingspondylitis AT iigoryainov effectofgolimumabonendothelialvasomotorfunctionandarterialstiffnessinankylosingspondylitis AT mastepchenko effectofgolimumabonendothelialvasomotorfunctionandarterialstiffnessinankylosingspondylitis AT yaibobyntsev effectofgolimumabonendothelialvasomotorfunctionandarterialstiffnessinankylosingspondylitis AT osrudakov effectofgolimumabonendothelialvasomotorfunctionandarterialstiffnessinankylosingspondylitis |