Copper-instigated modulatory cell mortality mechanisms and progress in kidney diseases
Copper is a vital cofactor in various enzymes, plays a pivotal role in maintaining cell homeostasis. When copper metabolism is disordered and mitochondrial dysfunction is impaired, programmed cell death such as apoptosis, paraptosis, pyroptosis, ferroptosis, cuproptosis, autophagy and necroptosis ca...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2431142 |
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| author | Xiya Ren Limei Zhao Yajie Hao Xiu Huang Guangna Lv Xiaoshuang Zhou |
| author_facet | Xiya Ren Limei Zhao Yajie Hao Xiu Huang Guangna Lv Xiaoshuang Zhou |
| author_sort | Xiya Ren |
| collection | DOAJ |
| description | Copper is a vital cofactor in various enzymes, plays a pivotal role in maintaining cell homeostasis. When copper metabolism is disordered and mitochondrial dysfunction is impaired, programmed cell death such as apoptosis, paraptosis, pyroptosis, ferroptosis, cuproptosis, autophagy and necroptosis can be induced. In this review, we focus on the metabolic mechanisms of copper. In addition, we discuss the mechanism by which copper induces various programmed cell deaths. Finally, this review examines copper’s involvement in prevalent kidney diseases such as acute kidney injury and chronic kidney disease. The findings indicate that the use of copper chelators or plant extracts can mitigate kidney damage by reducing copper accumulation, offering novel insights into the pathogenesis and treatment strategies for kidney diseases. |
| format | Article |
| id | doaj-art-a8d224d4d115487f9998ccaa8e8d32b0 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-a8d224d4d115487f9998ccaa8e8d32b02025-01-14T04:07:41ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2024.2431142Copper-instigated modulatory cell mortality mechanisms and progress in kidney diseasesXiya Ren0Limei Zhao1Yajie Hao2Xiu Huang3Guangna Lv4Xiaoshuang Zhou5The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, ChinaThe Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, ChinaThe Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, ChinaThe Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, ChinaThe Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Nephrology, Shanxi Provincial People’s Hospital, The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, ChinaCopper is a vital cofactor in various enzymes, plays a pivotal role in maintaining cell homeostasis. When copper metabolism is disordered and mitochondrial dysfunction is impaired, programmed cell death such as apoptosis, paraptosis, pyroptosis, ferroptosis, cuproptosis, autophagy and necroptosis can be induced. In this review, we focus on the metabolic mechanisms of copper. In addition, we discuss the mechanism by which copper induces various programmed cell deaths. Finally, this review examines copper’s involvement in prevalent kidney diseases such as acute kidney injury and chronic kidney disease. The findings indicate that the use of copper chelators or plant extracts can mitigate kidney damage by reducing copper accumulation, offering novel insights into the pathogenesis and treatment strategies for kidney diseases.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2431142Copper homeostasiscell deathkidney diseasescopper chelatortherapy |
| spellingShingle | Xiya Ren Limei Zhao Yajie Hao Xiu Huang Guangna Lv Xiaoshuang Zhou Copper-instigated modulatory cell mortality mechanisms and progress in kidney diseases Renal Failure Copper homeostasis cell death kidney diseases copper chelator therapy |
| title | Copper-instigated modulatory cell mortality mechanisms and progress in kidney diseases |
| title_full | Copper-instigated modulatory cell mortality mechanisms and progress in kidney diseases |
| title_fullStr | Copper-instigated modulatory cell mortality mechanisms and progress in kidney diseases |
| title_full_unstemmed | Copper-instigated modulatory cell mortality mechanisms and progress in kidney diseases |
| title_short | Copper-instigated modulatory cell mortality mechanisms and progress in kidney diseases |
| title_sort | copper instigated modulatory cell mortality mechanisms and progress in kidney diseases |
| topic | Copper homeostasis cell death kidney diseases copper chelator therapy |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2431142 |
| work_keys_str_mv | AT xiyaren copperinstigatedmodulatorycellmortalitymechanismsandprogressinkidneydiseases AT limeizhao copperinstigatedmodulatorycellmortalitymechanismsandprogressinkidneydiseases AT yajiehao copperinstigatedmodulatorycellmortalitymechanismsandprogressinkidneydiseases AT xiuhuang copperinstigatedmodulatorycellmortalitymechanismsandprogressinkidneydiseases AT guangnalv copperinstigatedmodulatorycellmortalitymechanismsandprogressinkidneydiseases AT xiaoshuangzhou copperinstigatedmodulatorycellmortalitymechanismsandprogressinkidneydiseases |