Management of acute liver failure during pregnancy by therapeutic plasma exchange – A multidisciplinary approach
Therapeutic plasma exchange (TPE) has been associated to improve survival in critically ill patients with liver failure who are not anticipated to survive until liver transplantation. In pregnant patients with acute liver failure (ALF), standard volume TPE can be done, foreseeing complications such...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-07-01
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| Series: | Asian Journal of Transfusion Science |
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| Online Access: | https://journals.lww.com/10.4103/ajts.ajts_169_23 |
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| author | Rishabh Bose Aswin K. Mohan Vaidehi Prasanth Davis Cherian Om Kumari Ashish Jain Daljit Kaur Gita Negi Anand Sharma |
| author_facet | Rishabh Bose Aswin K. Mohan Vaidehi Prasanth Davis Cherian Om Kumari Ashish Jain Daljit Kaur Gita Negi Anand Sharma |
| author_sort | Rishabh Bose |
| collection | DOAJ |
| description | Therapeutic plasma exchange (TPE) has been associated to improve survival in critically ill patients with liver failure who are not anticipated to survive until liver transplantation. In pregnant patients with acute liver failure (ALF), standard volume TPE can be done, foreseeing complications such as fetal distress, hypofibrinogenemia, hypercalcemia, and adverse transfusion reactions. TPE has been demonstrated to lower inflammatory cytokine levels, modify adaptive immunity with the potential to minimize infection susceptibility, and lower albumin and water-bound toxin levels in liver failure. In this article, the multidisciplinary approach, efficacy, and technical considerations were elaborated in the management of a young pregnant female diagnosed with ALF by TPE. |
| format | Article |
| id | doaj-art-a8cb8e2452474e1f9dae99ad93ccbb88 |
| institution | DOAJ |
| issn | 0973-6247 1998-3565 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj-art-a8cb8e2452474e1f9dae99ad93ccbb882025-08-20T02:56:21ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652025-07-0119115816210.4103/ajts.ajts_169_23Management of acute liver failure during pregnancy by therapeutic plasma exchange – A multidisciplinary approachRishabh BoseAswin K. MohanVaidehi PrasanthDavis CherianOm KumariAshish JainDaljit KaurGita NegiAnand SharmaTherapeutic plasma exchange (TPE) has been associated to improve survival in critically ill patients with liver failure who are not anticipated to survive until liver transplantation. In pregnant patients with acute liver failure (ALF), standard volume TPE can be done, foreseeing complications such as fetal distress, hypofibrinogenemia, hypercalcemia, and adverse transfusion reactions. TPE has been demonstrated to lower inflammatory cytokine levels, modify adaptive immunity with the potential to minimize infection susceptibility, and lower albumin and water-bound toxin levels in liver failure. In this article, the multidisciplinary approach, efficacy, and technical considerations were elaborated in the management of a young pregnant female diagnosed with ALF by TPE.https://journals.lww.com/10.4103/ajts.ajts_169_23acute liver failurecytokinesmultidisciplinary approachprecautions in pregnancytherapeutic plasma exchange in pregnancy |
| spellingShingle | Rishabh Bose Aswin K. Mohan Vaidehi Prasanth Davis Cherian Om Kumari Ashish Jain Daljit Kaur Gita Negi Anand Sharma Management of acute liver failure during pregnancy by therapeutic plasma exchange – A multidisciplinary approach Asian Journal of Transfusion Science acute liver failure cytokines multidisciplinary approach precautions in pregnancy therapeutic plasma exchange in pregnancy |
| title | Management of acute liver failure during pregnancy by therapeutic plasma exchange – A multidisciplinary approach |
| title_full | Management of acute liver failure during pregnancy by therapeutic plasma exchange – A multidisciplinary approach |
| title_fullStr | Management of acute liver failure during pregnancy by therapeutic plasma exchange – A multidisciplinary approach |
| title_full_unstemmed | Management of acute liver failure during pregnancy by therapeutic plasma exchange – A multidisciplinary approach |
| title_short | Management of acute liver failure during pregnancy by therapeutic plasma exchange – A multidisciplinary approach |
| title_sort | management of acute liver failure during pregnancy by therapeutic plasma exchange a multidisciplinary approach |
| topic | acute liver failure cytokines multidisciplinary approach precautions in pregnancy therapeutic plasma exchange in pregnancy |
| url | https://journals.lww.com/10.4103/ajts.ajts_169_23 |
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