Continuous Hemofiltration Reduces Mortality in Severe Acute Pancreatitis: A Meta-Analysis
Background. Severe acute pancreatitis (SAP) is a deadly condition, with a mortality rate ranging from 15% to 30%. Recently, blood purification therapy has been adopted in administrating SAP patients. The present study aimed at evaluating the effect of continuous hemofiltration therapy for SAP. Metho...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Emergency Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2020/6474308 |
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| author | Yulin Guo Feng Cao Chen Li Huaxia Yang Shaoyou Xia Fei Li |
| author_facet | Yulin Guo Feng Cao Chen Li Huaxia Yang Shaoyou Xia Fei Li |
| author_sort | Yulin Guo |
| collection | DOAJ |
| description | Background. Severe acute pancreatitis (SAP) is a deadly condition, with a mortality rate ranging from 15% to 30%. Recently, blood purification therapy has been adopted in administrating SAP patients. The present study aimed at evaluating the effect of continuous hemofiltration therapy for SAP. Methods. A systematic search of Cochrane Library, PubMed, and Embase was carried out until October 1st, 2019. Prospective studies comparing outcomes for SAP patients between continuous hemofiltration and standard therapy were enrolled. Results. Continuous hemofiltration therapy was associated with lower level of PACHE II score (MD = −1.49; 95% CI: −2.69 to −0.29, P=0.02), CRP (MD = −1.56 mg/L; 95% CI: −2.64 to −0.47, P=0.005), Cr (MD = −3.57 umol/L; 95% CI: −5.50 to −1.65, P=0.003), and Bun (MD = −3.63 mmol/L; 95% CI: −6.07 to −1.20, P=0.003) at 72 h after onset of treatment. Continuous hemofiltration therapy was associated with shorter length of abdominal pain relief time (MD = −1.82 hours; 95% CI: −2.93 to −0.71, P=0.001), lower surgery rate (OR = 0.15; 95% CI: 0.03 to 0.78, P=0.02), and mortality rate (OR = 0.54; 95% CI: 0.37 to 0.77, P=0.0007). Conclusions. continuous hemofiltration therapy could effectively alleviate SAP as early as 72 hours after onset of treatment, lowering the level of Bun, Cr, CRP, and APACHE II scores. Continuous hemofiltration therapy could confer SAP patients with lower mortality rates. |
| format | Article |
| id | doaj-art-a8ca354d86c346c584595cffa40c7f73 |
| institution | Kabale University |
| issn | 2090-2840 2090-2859 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Emergency Medicine International |
| spelling | doaj-art-a8ca354d86c346c584595cffa40c7f732025-02-03T06:43:24ZengWileyEmergency Medicine International2090-28402090-28592020-01-01202010.1155/2020/64743086474308Continuous Hemofiltration Reduces Mortality in Severe Acute Pancreatitis: A Meta-AnalysisYulin Guo0Feng Cao1Chen Li2Huaxia Yang3Shaoyou Xia4Fei Li5Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of General Surgery, PLA Army General Hospital, Beijing 100853, ChinaDepartment of General Surgery, PLA Army General Hospital, Beijing 100853, ChinaDepartment of General Surgery, PLA Army General Hospital, Beijing 100853, ChinaDepartment of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaBackground. Severe acute pancreatitis (SAP) is a deadly condition, with a mortality rate ranging from 15% to 30%. Recently, blood purification therapy has been adopted in administrating SAP patients. The present study aimed at evaluating the effect of continuous hemofiltration therapy for SAP. Methods. A systematic search of Cochrane Library, PubMed, and Embase was carried out until October 1st, 2019. Prospective studies comparing outcomes for SAP patients between continuous hemofiltration and standard therapy were enrolled. Results. Continuous hemofiltration therapy was associated with lower level of PACHE II score (MD = −1.49; 95% CI: −2.69 to −0.29, P=0.02), CRP (MD = −1.56 mg/L; 95% CI: −2.64 to −0.47, P=0.005), Cr (MD = −3.57 umol/L; 95% CI: −5.50 to −1.65, P=0.003), and Bun (MD = −3.63 mmol/L; 95% CI: −6.07 to −1.20, P=0.003) at 72 h after onset of treatment. Continuous hemofiltration therapy was associated with shorter length of abdominal pain relief time (MD = −1.82 hours; 95% CI: −2.93 to −0.71, P=0.001), lower surgery rate (OR = 0.15; 95% CI: 0.03 to 0.78, P=0.02), and mortality rate (OR = 0.54; 95% CI: 0.37 to 0.77, P=0.0007). Conclusions. continuous hemofiltration therapy could effectively alleviate SAP as early as 72 hours after onset of treatment, lowering the level of Bun, Cr, CRP, and APACHE II scores. Continuous hemofiltration therapy could confer SAP patients with lower mortality rates.http://dx.doi.org/10.1155/2020/6474308 |
| spellingShingle | Yulin Guo Feng Cao Chen Li Huaxia Yang Shaoyou Xia Fei Li Continuous Hemofiltration Reduces Mortality in Severe Acute Pancreatitis: A Meta-Analysis Emergency Medicine International |
| title | Continuous Hemofiltration Reduces Mortality in Severe Acute Pancreatitis: A Meta-Analysis |
| title_full | Continuous Hemofiltration Reduces Mortality in Severe Acute Pancreatitis: A Meta-Analysis |
| title_fullStr | Continuous Hemofiltration Reduces Mortality in Severe Acute Pancreatitis: A Meta-Analysis |
| title_full_unstemmed | Continuous Hemofiltration Reduces Mortality in Severe Acute Pancreatitis: A Meta-Analysis |
| title_short | Continuous Hemofiltration Reduces Mortality in Severe Acute Pancreatitis: A Meta-Analysis |
| title_sort | continuous hemofiltration reduces mortality in severe acute pancreatitis a meta analysis |
| url | http://dx.doi.org/10.1155/2020/6474308 |
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