Developmental Defects in Trisomy 21 and Mouse Models
Aneuploidies have diverse phenotypic consequences, ranging from mental retardation and developmental abnormalities to susceptibility to common phenotypes and various neoplasms. This review focuses on the developmental defects of murine models of a prototype human aneuploidy: trisomy 21 (Down syndrom...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2006.322 |
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| author | Jean Maurice Delabar Revital Aflalo-Rattenbac Nicole Créau |
| author_facet | Jean Maurice Delabar Revital Aflalo-Rattenbac Nicole Créau |
| author_sort | Jean Maurice Delabar |
| collection | DOAJ |
| description | Aneuploidies have diverse phenotypic consequences, ranging from mental retardation and developmental abnormalities to susceptibility to common phenotypes and various neoplasms. This review focuses on the developmental defects of murine models of a prototype human aneuploidy: trisomy 21 (Down syndrome, DS, T21). Murine models are clearly the best tool for dissecting the phenotypic consequences of imbalances that affect single genes or chromosome segments. Embryos can be studied freely in mice, making murine models particularly useful for the characterization of developmental abnormalities. This review describes the main phenotypic alterations occurring during the development of patients with T21 and the developmental abnormalities observed in mouse models, and investigates phenotypes common to both species. |
| format | Article |
| id | doaj-art-a8c5efdd7f264475acfcacaea2bc4d9f |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-a8c5efdd7f264475acfcacaea2bc4d9f2025-02-03T05:59:14ZengWileyThe Scientific World Journal1537-744X2006-01-0161945196410.1100/tsw.2006.322Developmental Defects in Trisomy 21 and Mouse ModelsJean Maurice Delabar0Revital Aflalo-Rattenbac1Nicole Créau2EA3508, Université Denis Diderot — Paris 7, 2 place Jussieu 75251 Paris Cedex 05, FranceEA3508, Université Denis Diderot — Paris 7, 2 place Jussieu 75251 Paris Cedex 05, FranceEA3508, Université Denis Diderot — Paris 7, 2 place Jussieu 75251 Paris Cedex 05, FranceAneuploidies have diverse phenotypic consequences, ranging from mental retardation and developmental abnormalities to susceptibility to common phenotypes and various neoplasms. This review focuses on the developmental defects of murine models of a prototype human aneuploidy: trisomy 21 (Down syndrome, DS, T21). Murine models are clearly the best tool for dissecting the phenotypic consequences of imbalances that affect single genes or chromosome segments. Embryos can be studied freely in mice, making murine models particularly useful for the characterization of developmental abnormalities. This review describes the main phenotypic alterations occurring during the development of patients with T21 and the developmental abnormalities observed in mouse models, and investigates phenotypes common to both species.http://dx.doi.org/10.1100/tsw.2006.322 |
| spellingShingle | Jean Maurice Delabar Revital Aflalo-Rattenbac Nicole Créau Developmental Defects in Trisomy 21 and Mouse Models The Scientific World Journal |
| title | Developmental Defects in Trisomy 21 and Mouse Models |
| title_full | Developmental Defects in Trisomy 21 and Mouse Models |
| title_fullStr | Developmental Defects in Trisomy 21 and Mouse Models |
| title_full_unstemmed | Developmental Defects in Trisomy 21 and Mouse Models |
| title_short | Developmental Defects in Trisomy 21 and Mouse Models |
| title_sort | developmental defects in trisomy 21 and mouse models |
| url | http://dx.doi.org/10.1100/tsw.2006.322 |
| work_keys_str_mv | AT jeanmauricedelabar developmentaldefectsintrisomy21andmousemodels AT revitalaflalorattenbac developmentaldefectsintrisomy21andmousemodels AT nicolecreau developmentaldefectsintrisomy21andmousemodels |