Clinical impacts of COVID-19 on severe exacerbation and mortality in interstitial lung disease: prognosis 30 days after infection
Background/Aims The impact of coronavirus disease 2019 (COVID-19) on severe exacerbation and mortality in interstitial lung disease (ILD) is unclear. In this study, we evaluate the risk of severe exacerbation and mortality in individuals with ILD following COVID-19. Methods Using the Korean National...
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The Korean Association of Internal Medicine
2025-07-01
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| Series: | The Korean Journal of Internal Medicine |
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| Online Access: | http://kjim.org/upload/kjim-2024-388.pdf |
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| author | Bo-Guen Kim Sun-Kyung Lee Dong Won Park Tai Sun Park Ji-Yong Moon Tae-Hyung Kim Sang-Heon Kim Ho Joo Yoon Hyun Lee |
| author_facet | Bo-Guen Kim Sun-Kyung Lee Dong Won Park Tai Sun Park Ji-Yong Moon Tae-Hyung Kim Sang-Heon Kim Ho Joo Yoon Hyun Lee |
| author_sort | Bo-Guen Kim |
| collection | DOAJ |
| description | Background/Aims The impact of coronavirus disease 2019 (COVID-19) on severe exacerbation and mortality in interstitial lung disease (ILD) is unclear. In this study, we evaluate the risk of severe exacerbation and mortality in individuals with ILD following COVID-19. Methods Using the Korean National Health Insurance claim-based database, we compared the incidence and risk of severe exacerbation and mortality in individuals with ILD who survived at least one month after COVID-19 (COVID-19 cohort, n = 359) and 1:3 age, sex, and body mass index-matched individuals with ILD who did not have COVID-19 (controls, n = 1,077) between October 8, 2020, and August 30, 2021. Results During a mean follow-up of 7.4 months, the COVID-19 cohort had a higher risk of severe exacerbation compared to controls (aHR 2.26, 95% CI 1.38–3.69). During a mean follow-up of 19.6 months, the COVID-19 cohort had a higher risk of death (aHR 2.79, 95% CI 1.63–4.79) compared to controls. When considering COVID-19 severity, the severe COVID-19 group had a higher risk of severe exacerbation and death compared to controls, while the non-severe COVID-19 group did not show increased risk of severe exacerbation or death. In analyses based on ILD subtype, individuals with idiopathic pulmonary fibrosis in the COVID-19 cohort had the highest risk of severe exacerbation and death. Conclusions Previous severe COVID-19 was associated with worse clinical outcomes in individuals with ILD, especially in patients with idiopathic pulmonary fibrosis. |
| format | Article |
| id | doaj-art-a8c5323ec5af41c49e2d161ac2019dcc |
| institution | DOAJ |
| issn | 1226-3303 2005-6648 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj-art-a8c5323ec5af41c49e2d161ac2019dcc2025-08-20T02:47:28ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482025-07-0140463464410.3904/kjim.2024.388171037Clinical impacts of COVID-19 on severe exacerbation and mortality in interstitial lung disease: prognosis 30 days after infectionBo-Guen Kim0Sun-Kyung Lee1Dong Won Park2Tai Sun Park3Ji-Yong Moon4Tae-Hyung Kim5Sang-Heon Kim6Ho Joo Yoon7Hyun Lee8 Division of Pulmonary Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, Korea Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea Department of Internal Medicine, Hanyang University College of Medicine, Seoul, KoreaBackground/Aims The impact of coronavirus disease 2019 (COVID-19) on severe exacerbation and mortality in interstitial lung disease (ILD) is unclear. In this study, we evaluate the risk of severe exacerbation and mortality in individuals with ILD following COVID-19. Methods Using the Korean National Health Insurance claim-based database, we compared the incidence and risk of severe exacerbation and mortality in individuals with ILD who survived at least one month after COVID-19 (COVID-19 cohort, n = 359) and 1:3 age, sex, and body mass index-matched individuals with ILD who did not have COVID-19 (controls, n = 1,077) between October 8, 2020, and August 30, 2021. Results During a mean follow-up of 7.4 months, the COVID-19 cohort had a higher risk of severe exacerbation compared to controls (aHR 2.26, 95% CI 1.38–3.69). During a mean follow-up of 19.6 months, the COVID-19 cohort had a higher risk of death (aHR 2.79, 95% CI 1.63–4.79) compared to controls. When considering COVID-19 severity, the severe COVID-19 group had a higher risk of severe exacerbation and death compared to controls, while the non-severe COVID-19 group did not show increased risk of severe exacerbation or death. In analyses based on ILD subtype, individuals with idiopathic pulmonary fibrosis in the COVID-19 cohort had the highest risk of severe exacerbation and death. Conclusions Previous severe COVID-19 was associated with worse clinical outcomes in individuals with ILD, especially in patients with idiopathic pulmonary fibrosis.http://kjim.org/upload/kjim-2024-388.pdfcovid-19interstitial lung diseasesmortality |
| spellingShingle | Bo-Guen Kim Sun-Kyung Lee Dong Won Park Tai Sun Park Ji-Yong Moon Tae-Hyung Kim Sang-Heon Kim Ho Joo Yoon Hyun Lee Clinical impacts of COVID-19 on severe exacerbation and mortality in interstitial lung disease: prognosis 30 days after infection The Korean Journal of Internal Medicine covid-19 interstitial lung diseases mortality |
| title | Clinical impacts of COVID-19 on severe exacerbation and mortality in interstitial lung disease: prognosis 30 days after infection |
| title_full | Clinical impacts of COVID-19 on severe exacerbation and mortality in interstitial lung disease: prognosis 30 days after infection |
| title_fullStr | Clinical impacts of COVID-19 on severe exacerbation and mortality in interstitial lung disease: prognosis 30 days after infection |
| title_full_unstemmed | Clinical impacts of COVID-19 on severe exacerbation and mortality in interstitial lung disease: prognosis 30 days after infection |
| title_short | Clinical impacts of COVID-19 on severe exacerbation and mortality in interstitial lung disease: prognosis 30 days after infection |
| title_sort | clinical impacts of covid 19 on severe exacerbation and mortality in interstitial lung disease prognosis 30 days after infection |
| topic | covid-19 interstitial lung diseases mortality |
| url | http://kjim.org/upload/kjim-2024-388.pdf |
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