Colorectal Cancer and Basement Membranes: Clinicopathological Correlations
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females. In 2008, an estimated 1.2 million people were diagnosed with and 608,700 people died of CRC. Besides diagnosis and treatment, prognosis is an important matter for cancer patients. Today, clinicopa...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/580159 |
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| author | Charalampos C. Mylonas Andreas C. Lazaris |
| author_facet | Charalampos C. Mylonas Andreas C. Lazaris |
| author_sort | Charalampos C. Mylonas |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females. In 2008, an estimated 1.2 million people were diagnosed with and 608,700 people died of CRC. Besides diagnosis and treatment, prognosis is an important matter for cancer patients. Today, clinicopathological correlations have many applications in cancer prognostication. Examples include the prediction of the medium patient survival and the screening for patients suitable for specific therapeutic approaches. Apart from traditional prognostic factors, such as tumor stage and grade, new markers may be useful in clinical practice. Possible markers may result from the study of basement membranes (BMs). BM seems to play a role in the pathogenesis of colorectal cancer, so BM alterations may have prognostic significance as well. The purpose of this review is to briefly describe BMs and their relationship with CRC, in the aspect of clinicopathological correlations. |
| format | Article |
| id | doaj-art-a8c3830f05d94a64a34ad5de3fbd3dce |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-a8c3830f05d94a64a34ad5de3fbd3dce2025-02-03T01:31:33ZengWileyGastroenterology Research and Practice1687-61211687-630X2014-01-01201410.1155/2014/580159580159Colorectal Cancer and Basement Membranes: Clinicopathological CorrelationsCharalampos C. Mylonas0Andreas C. Lazaris11st Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece1st Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, GreeceColorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females. In 2008, an estimated 1.2 million people were diagnosed with and 608,700 people died of CRC. Besides diagnosis and treatment, prognosis is an important matter for cancer patients. Today, clinicopathological correlations have many applications in cancer prognostication. Examples include the prediction of the medium patient survival and the screening for patients suitable for specific therapeutic approaches. Apart from traditional prognostic factors, such as tumor stage and grade, new markers may be useful in clinical practice. Possible markers may result from the study of basement membranes (BMs). BM seems to play a role in the pathogenesis of colorectal cancer, so BM alterations may have prognostic significance as well. The purpose of this review is to briefly describe BMs and their relationship with CRC, in the aspect of clinicopathological correlations.http://dx.doi.org/10.1155/2014/580159 |
| spellingShingle | Charalampos C. Mylonas Andreas C. Lazaris Colorectal Cancer and Basement Membranes: Clinicopathological Correlations Gastroenterology Research and Practice |
| title | Colorectal Cancer and Basement Membranes: Clinicopathological Correlations |
| title_full | Colorectal Cancer and Basement Membranes: Clinicopathological Correlations |
| title_fullStr | Colorectal Cancer and Basement Membranes: Clinicopathological Correlations |
| title_full_unstemmed | Colorectal Cancer and Basement Membranes: Clinicopathological Correlations |
| title_short | Colorectal Cancer and Basement Membranes: Clinicopathological Correlations |
| title_sort | colorectal cancer and basement membranes clinicopathological correlations |
| url | http://dx.doi.org/10.1155/2014/580159 |
| work_keys_str_mv | AT charalamposcmylonas colorectalcancerandbasementmembranesclinicopathologicalcorrelations AT andreasclazaris colorectalcancerandbasementmembranesclinicopathologicalcorrelations |