Bone marrow immune cells and drug resistance in acute myeloid leukemia
In recent years, the relationship between the immunosuppressive niche of the bone marrow and therapy resistance in acute myeloid leukemia (AML) has become a research focus. The abnormal number and function of immunosuppressive cells, including regulatory T cells (Tregs) and myeloid-derived suppresso...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Experimental Biology and Medicine |
| Subjects: | |
| Online Access: | https://www.ebm-journal.org/articles/10.3389/ebm.2025.10235/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823858358828924928 |
|---|---|
| author | Miao Zhang Miao Zhang You Yang You Yang Jing Liu Jing Liu Ling Guo Ling Guo Qulian Guo Qulian Guo Wenjun Liu Wenjun Liu |
| author_facet | Miao Zhang Miao Zhang You Yang You Yang Jing Liu Jing Liu Ling Guo Ling Guo Qulian Guo Qulian Guo Wenjun Liu Wenjun Liu |
| author_sort | Miao Zhang |
| collection | DOAJ |
| description | In recent years, the relationship between the immunosuppressive niche of the bone marrow and therapy resistance in acute myeloid leukemia (AML) has become a research focus. The abnormal number and function of immunosuppressive cells, including regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), along with the dysfunction and exhaustion of immunological effector cells, including cytotoxic T lymphocytes (CTLs), dendritic cells (DCs) and natural killer cells (NKs), can induce immune escape of leukemia cells and are closely linked to therapy resistance in leukemia. This article reviews the research progress on the relationship between immune cells in the marrow microenvironment and chemoresistance in AML, aiming to provide new ideas for the immunotherapy of AML. |
| format | Article |
| id | doaj-art-a8c31365db64439daea0adf13837ae45 |
| institution | Kabale University |
| issn | 1535-3699 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Experimental Biology and Medicine |
| spelling | doaj-art-a8c31365db64439daea0adf13837ae452025-02-11T11:51:04ZengFrontiers Media S.A.Experimental Biology and Medicine1535-36992025-02-0125010.3389/ebm.2025.1023510235Bone marrow immune cells and drug resistance in acute myeloid leukemiaMiao Zhang0Miao Zhang1You Yang2You Yang3Jing Liu4Jing Liu5Ling Guo6Ling Guo7Qulian Guo8Qulian Guo9Wenjun Liu10Wenjun Liu11Department of Pediatrics (Hematological Oncology), Children Hematological Oncology and Birth Defects Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Birth Defects, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Pediatrics (Hematological Oncology), Children Hematological Oncology and Birth Defects Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Birth Defects, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Pediatrics (Hematological Oncology), Children Hematological Oncology and Birth Defects Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Birth Defects, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Pediatrics (Hematological Oncology), Children Hematological Oncology and Birth Defects Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Birth Defects, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Pediatrics (Hematological Oncology), Children Hematological Oncology and Birth Defects Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Birth Defects, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Pediatrics (Hematological Oncology), Children Hematological Oncology and Birth Defects Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Birth Defects, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaIn recent years, the relationship between the immunosuppressive niche of the bone marrow and therapy resistance in acute myeloid leukemia (AML) has become a research focus. The abnormal number and function of immunosuppressive cells, including regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), along with the dysfunction and exhaustion of immunological effector cells, including cytotoxic T lymphocytes (CTLs), dendritic cells (DCs) and natural killer cells (NKs), can induce immune escape of leukemia cells and are closely linked to therapy resistance in leukemia. This article reviews the research progress on the relationship between immune cells in the marrow microenvironment and chemoresistance in AML, aiming to provide new ideas for the immunotherapy of AML.https://www.ebm-journal.org/articles/10.3389/ebm.2025.10235/fullleukemiaimmune cellsdrug resistancebone marrowimmunosuppressive microenvironment |
| spellingShingle | Miao Zhang Miao Zhang You Yang You Yang Jing Liu Jing Liu Ling Guo Ling Guo Qulian Guo Qulian Guo Wenjun Liu Wenjun Liu Bone marrow immune cells and drug resistance in acute myeloid leukemia Experimental Biology and Medicine leukemia immune cells drug resistance bone marrow immunosuppressive microenvironment |
| title | Bone marrow immune cells and drug resistance in acute myeloid leukemia |
| title_full | Bone marrow immune cells and drug resistance in acute myeloid leukemia |
| title_fullStr | Bone marrow immune cells and drug resistance in acute myeloid leukemia |
| title_full_unstemmed | Bone marrow immune cells and drug resistance in acute myeloid leukemia |
| title_short | Bone marrow immune cells and drug resistance in acute myeloid leukemia |
| title_sort | bone marrow immune cells and drug resistance in acute myeloid leukemia |
| topic | leukemia immune cells drug resistance bone marrow immunosuppressive microenvironment |
| url | https://www.ebm-journal.org/articles/10.3389/ebm.2025.10235/full |
| work_keys_str_mv | AT miaozhang bonemarrowimmunecellsanddrugresistanceinacutemyeloidleukemia AT miaozhang bonemarrowimmunecellsanddrugresistanceinacutemyeloidleukemia AT youyang bonemarrowimmunecellsanddrugresistanceinacutemyeloidleukemia AT youyang bonemarrowimmunecellsanddrugresistanceinacutemyeloidleukemia AT jingliu bonemarrowimmunecellsanddrugresistanceinacutemyeloidleukemia AT jingliu bonemarrowimmunecellsanddrugresistanceinacutemyeloidleukemia AT lingguo bonemarrowimmunecellsanddrugresistanceinacutemyeloidleukemia AT lingguo bonemarrowimmunecellsanddrugresistanceinacutemyeloidleukemia AT qulianguo bonemarrowimmunecellsanddrugresistanceinacutemyeloidleukemia AT qulianguo bonemarrowimmunecellsanddrugresistanceinacutemyeloidleukemia AT wenjunliu bonemarrowimmunecellsanddrugresistanceinacutemyeloidleukemia AT wenjunliu bonemarrowimmunecellsanddrugresistanceinacutemyeloidleukemia |