Thermolabile drugs stability faced with an accidental interruption in the cold chain
Objective: To develop an updated guide about the stability of thermolabiledrugs included in the Pharmacotherapeutic Guide that,according to product information sheet, should be stored underrefrigeration or freezing, when are accidentally exposed to temperaturesoutside the range recommended by the ma...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-05-01
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| Series: | Farmacia Hospitalaria |
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| Online Access: | http://www.aulamedica.es/fh/pdf/1164.pdf |
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| author | I. Ricote-Lobera B. Ortiz-Martín S. Fraile-Gil B. Santos-Mena F. J. Hidalgo-Correas B. García-Díaz |
| author_facet | I. Ricote-Lobera B. Ortiz-Martín S. Fraile-Gil B. Santos-Mena F. J. Hidalgo-Correas B. García-Díaz |
| author_sort | I. Ricote-Lobera |
| collection | DOAJ |
| description | Objective: To develop an updated guide about the stability of thermolabiledrugs included in the Pharmacotherapeutic Guide that,according to product information sheet, should be stored underrefrigeration or freezing, when are accidentally exposed to temperaturesoutside the range recommended by the manufacturer.
Methods: It was reviewed the information about storage temperaturesrecommended in the product information sheet andthe available stability data at different temperatures of thermolabiledrugs included in the Pharmacotherapeutic Guide of a400-bed hospital that, according to the manufacturer, shouldbe stored under refrigeration or freezing. Drugs of clinical trialswere excluded. Stability data were obtained from the productinformation sheet, the last two guides published in Spain aboutthermolabile drugs and through consultations to laboratories(via phone or e-mail).
Results: It was created a table with the storage temperaturesrecommended in the product information sheet and currentlyavailable stability data at different temperatures of 209 presentationsof several drugs. Stability data were requested to laboratoriesin 172 cases.
Conclusions: The stability guide is a tool that facilitates decisionsof pharmacists when they are faced with an accidentalinterruption of the cold chain, when it is
necessary to knowwhether the drug can be used and it is not possible to contactthe laboratory |
| format | Article |
| id | doaj-art-a8c1d675d95b4810b87d61a70aca7bf8 |
| institution | Kabale University |
| issn | 1130-6343 2171-8695 |
| language | English |
| publishDate | 2014-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Farmacia Hospitalaria |
| spelling | doaj-art-a8c1d675d95b4810b87d61a70aca7bf82025-01-02T16:24:44ZengElsevierFarmacia Hospitalaria1130-63432171-86952014-05-0138316919210.7399/fh.2014.38.3.1164Thermolabile drugs stability faced with an accidental interruption in the cold chainI. Ricote-Lobera0B. Ortiz-Martín1S. Fraile-Gil2B. Santos-Mena3F. J. Hidalgo-Correas4B. García-Díaz5Farmacéutica Especialista en Farmacia Hospitalaria. Servicio de Farmacia.Residente de Farmacia Hospitalaria. Servicio de FarmaciaFarmacéutica Especialista en Farmacia Hospitalaria. Servicio de Farmacia.Farmacéutica Especialista en Farmacia Hospitalaria. Servicio de Farmacia.Farmacéutica Especialista en Farmacia Hospitalaria. Servicio de Farmacia.Jefe de Servicio. Servicio de Farmacia. Hospital Universitario Severo Ochoa. Leganés. Madrid. EspañaObjective: To develop an updated guide about the stability of thermolabiledrugs included in the Pharmacotherapeutic Guide that,according to product information sheet, should be stored underrefrigeration or freezing, when are accidentally exposed to temperaturesoutside the range recommended by the manufacturer. Methods: It was reviewed the information about storage temperaturesrecommended in the product information sheet andthe available stability data at different temperatures of thermolabiledrugs included in the Pharmacotherapeutic Guide of a400-bed hospital that, according to the manufacturer, shouldbe stored under refrigeration or freezing. Drugs of clinical trialswere excluded. Stability data were obtained from the productinformation sheet, the last two guides published in Spain aboutthermolabile drugs and through consultations to laboratories(via phone or e-mail). Results: It was created a table with the storage temperaturesrecommended in the product information sheet and currentlyavailable stability data at different temperatures of 209 presentationsof several drugs. Stability data were requested to laboratoriesin 172 cases. Conclusions: The stability guide is a tool that facilitates decisionsof pharmacists when they are faced with an accidentalinterruption of the cold chain, when it is necessary to knowwhether the drug can be used and it is not possible to contactthe laboratoryhttp://www.aulamedica.es/fh/pdf/1164.pdfThermolabile drugs; Cold chainDrug stability; Storagetemperature; Refrigerated storageProtocolPharmacist |
| spellingShingle | I. Ricote-Lobera B. Ortiz-Martín S. Fraile-Gil B. Santos-Mena F. J. Hidalgo-Correas B. García-Díaz Thermolabile drugs stability faced with an accidental interruption in the cold chain Farmacia Hospitalaria Thermolabile drugs ; Cold chain Drug stability ; Storagetemperature ; Refrigerated storage Protocol Pharmacist |
| title | Thermolabile drugs stability faced with an accidental interruption in the cold chain |
| title_full | Thermolabile drugs stability faced with an accidental interruption in the cold chain |
| title_fullStr | Thermolabile drugs stability faced with an accidental interruption in the cold chain |
| title_full_unstemmed | Thermolabile drugs stability faced with an accidental interruption in the cold chain |
| title_short | Thermolabile drugs stability faced with an accidental interruption in the cold chain |
| title_sort | thermolabile drugs stability faced with an accidental interruption in the cold chain |
| topic | Thermolabile drugs ; Cold chain Drug stability ; Storagetemperature ; Refrigerated storage Protocol Pharmacist |
| url | http://www.aulamedica.es/fh/pdf/1164.pdf |
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