The potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy: State of art and ongoing perspective
Epilepsy is a neurological disease characterized by unprovoked recurrent epileptic seizures. Temporal lobe epilepsy (TLE) is the commonest type of focal epilepsy in adults that resist to the conventional anti-seizure medications (ASMs). Interestingly, ASMs do not affect the epileptogenesis and progr...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025000012 |
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| author | Bshra A. Alsfouk Hayder M. Al-Kuraishy Ali K. Albuhadily Ali I. Al-Gareeb Ahmed M. Abdelaziz Athanasios Alexiou Marios Papadakis Mubarak Alruwaili Gaber El-Saber Batiha |
| author_facet | Bshra A. Alsfouk Hayder M. Al-Kuraishy Ali K. Albuhadily Ali I. Al-Gareeb Ahmed M. Abdelaziz Athanasios Alexiou Marios Papadakis Mubarak Alruwaili Gaber El-Saber Batiha |
| author_sort | Bshra A. Alsfouk |
| collection | DOAJ |
| description | Epilepsy is a neurological disease characterized by unprovoked recurrent epileptic seizures. Temporal lobe epilepsy (TLE) is the commonest type of focal epilepsy in adults that resist to the conventional anti-seizure medications (ASMs). Interestingly, ASMs do not affect the epileptogenesis and progression of disease. Therefore, repurposing of natural products with anti-inflammatory, anti-oxidant and anti-seizure effects such as berberine (BRB) may be logical in treating refractory epilepsy and TLE. However, the molecular mechanism of BRB against the development of epilepsy and progression of epileptic seizure mainly in TLE was not fully elucidated. Therefore, we attempt in this review to discuss the potential underlying molecular mechanism of BRB against the development and progression of epilepsy mainly the TLE. |
| format | Article |
| id | doaj-art-a8c0b154e5b84b048cc2f09f629dab80 |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-a8c0b154e5b84b048cc2f09f629dab802025-02-07T04:46:39ZengElsevierBrain Research Bulletin1873-27472025-02-01221111189The potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy: State of art and ongoing perspectiveBshra A. Alsfouk0Hayder M. Al-Kuraishy1Ali K. Albuhadily2Ali I. Al-Gareeb3Ahmed M. Abdelaziz4Athanasios Alexiou5Marios Papadakis6Mubarak Alruwaili7Gaber El-Saber Batiha8Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi ArabiaDepartment of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad 14132, IraqDepartment of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad 14132, IraqDepartment of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad 14132, Iraq; Jabir ibn Hayyan Medical University, Al-Ameer Qu./Najaf-Iraq, PO. Box13, Kufa, IraqDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Sinai University, Arish Branch, Arish 45511, EgyptUniversity Centre for Research & Development, Chandigarh University, Mohali, India; Department of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, New South Wales, Australia; Department of Research & Development, Funogen, Athens, GreeceUniversity Hospital Witten-Herdecke, University of Witten, Herdecke, Heusnerstrasse 40, Wuppertal 42283, Germany; Corresponding author.Department of Internal Medicine, College of Medicine, Jouf University, Sakaka, Saudi ArabiaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, AlBeheira 22511, EgyptEpilepsy is a neurological disease characterized by unprovoked recurrent epileptic seizures. Temporal lobe epilepsy (TLE) is the commonest type of focal epilepsy in adults that resist to the conventional anti-seizure medications (ASMs). Interestingly, ASMs do not affect the epileptogenesis and progression of disease. Therefore, repurposing of natural products with anti-inflammatory, anti-oxidant and anti-seizure effects such as berberine (BRB) may be logical in treating refractory epilepsy and TLE. However, the molecular mechanism of BRB against the development of epilepsy and progression of epileptic seizure mainly in TLE was not fully elucidated. Therefore, we attempt in this review to discuss the potential underlying molecular mechanism of BRB against the development and progression of epilepsy mainly the TLE.http://www.sciencedirect.com/science/article/pii/S0361923025000012EpilepsyTemporal lobe epilepsyBerberine |
| spellingShingle | Bshra A. Alsfouk Hayder M. Al-Kuraishy Ali K. Albuhadily Ali I. Al-Gareeb Ahmed M. Abdelaziz Athanasios Alexiou Marios Papadakis Mubarak Alruwaili Gaber El-Saber Batiha The potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy: State of art and ongoing perspective Brain Research Bulletin Epilepsy Temporal lobe epilepsy Berberine |
| title | The potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy: State of art and ongoing perspective |
| title_full | The potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy: State of art and ongoing perspective |
| title_fullStr | The potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy: State of art and ongoing perspective |
| title_full_unstemmed | The potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy: State of art and ongoing perspective |
| title_short | The potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy: State of art and ongoing perspective |
| title_sort | potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy state of art and ongoing perspective |
| topic | Epilepsy Temporal lobe epilepsy Berberine |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025000012 |
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