Dexmedetomidine as a Cardioprotector in Cardiac Surgery (Review)
The literature review presents an analysis of publications on the use of a selective α2-adrenergic receptor agonist (α2-AR) dexmedetomidine as a cardioprotector in cardiosurgical interventions. It summarizes historical aspects of the introduction of α2-AR agonists in the intensive care practice. It...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2017-09-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/1603 |
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| author | I. A. Kozlov T. V. Klypa I. O. Antonov |
| author_facet | I. A. Kozlov T. V. Klypa I. O. Antonov |
| author_sort | I. A. Kozlov |
| collection | DOAJ |
| description | The literature review presents an analysis of publications on the use of a selective α2-adrenergic receptor agonist (α2-AR) dexmedetomidine as a cardioprotector in cardiosurgical interventions. It summarizes historical aspects of the introduction of α2-AR agonists in the intensive care practice. It analyzes possible mechanisms of the cardioprotective effect of dexmedetomidine (central sympatholysis, favorable effects on the coronary circulation and relief of the coronary steal syndrome in originally ischemized areas of the myocardium, antiinflammatory and antioxidant effects, and prevention of apoptosis activation). Data from experimental studies of dexmedetomidine cardioprotection were analyzed. Results of clinical studies, including data of metanalyses, were discussed. It dwells on data on the favorable effect of dexmedetomidine on various parameters of the postoperative period, including a decreased risk of delirium, general complications of cardiosurgical interventions, and the mortality rate in patients. It presents data on cardioprotective properties of dexmedetomidine in surgical patients who undergo noncardiac interventions, particularly vascular ones, including high risk surgeries in the aorta. A comparative analysis of results of clinical trials studying the dexmedetomidine cardioprotection during surgeries with extracorporeal circulation was performed. A range of pharmacological effects of dexmedetomidine during anesthesiological support of cardiac surgeries, including those in elderly and senile patients, was described. It has been concluded that the dexmedetomidine cardioprotection in the various fields of surgery is obviously very promising. |
| format | Article |
| id | doaj-art-a8bc558c49274846bb2afaff039d1981 |
| institution | Kabale University |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2017-09-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-a8bc558c49274846bb2afaff039d19812025-08-20T03:35:08ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102017-09-01134466310.15360/1813-9779-2017-4-46-631566Dexmedetomidine as a Cardioprotector in Cardiac Surgery (Review)I. A. Kozlov0T. V. Klypa1I. O. Antonov2M.F. Vladimirsky Moscow Regional Research Clinical InstituteFederal Research and Clinical Center of Federal Medical and Biological agency of RussiaFederal Research and Clinical Center of Federal Medical and Biological agency of RussiaThe literature review presents an analysis of publications on the use of a selective α2-adrenergic receptor agonist (α2-AR) dexmedetomidine as a cardioprotector in cardiosurgical interventions. It summarizes historical aspects of the introduction of α2-AR agonists in the intensive care practice. It analyzes possible mechanisms of the cardioprotective effect of dexmedetomidine (central sympatholysis, favorable effects on the coronary circulation and relief of the coronary steal syndrome in originally ischemized areas of the myocardium, antiinflammatory and antioxidant effects, and prevention of apoptosis activation). Data from experimental studies of dexmedetomidine cardioprotection were analyzed. Results of clinical studies, including data of metanalyses, were discussed. It dwells on data on the favorable effect of dexmedetomidine on various parameters of the postoperative period, including a decreased risk of delirium, general complications of cardiosurgical interventions, and the mortality rate in patients. It presents data on cardioprotective properties of dexmedetomidine in surgical patients who undergo noncardiac interventions, particularly vascular ones, including high risk surgeries in the aorta. A comparative analysis of results of clinical trials studying the dexmedetomidine cardioprotection during surgeries with extracorporeal circulation was performed. A range of pharmacological effects of dexmedetomidine during anesthesiological support of cardiac surgeries, including those in elderly and senile patients, was described. It has been concluded that the dexmedetomidine cardioprotection in the various fields of surgery is obviously very promising.https://www.reanimatology.com/rmt/article/view/1603dexmedetomidineadjuvant cardioprotectionα2-adrenergic receptors agonistssympatholysisextracorporeal circulationcomplications of cardiac surgery |
| spellingShingle | I. A. Kozlov T. V. Klypa I. O. Antonov Dexmedetomidine as a Cardioprotector in Cardiac Surgery (Review) Общая реаниматология dexmedetomidine adjuvant cardioprotection α2-adrenergic receptors agonists sympatholysis extracorporeal circulation complications of cardiac surgery |
| title | Dexmedetomidine as a Cardioprotector in Cardiac Surgery (Review) |
| title_full | Dexmedetomidine as a Cardioprotector in Cardiac Surgery (Review) |
| title_fullStr | Dexmedetomidine as a Cardioprotector in Cardiac Surgery (Review) |
| title_full_unstemmed | Dexmedetomidine as a Cardioprotector in Cardiac Surgery (Review) |
| title_short | Dexmedetomidine as a Cardioprotector in Cardiac Surgery (Review) |
| title_sort | dexmedetomidine as a cardioprotector in cardiac surgery review |
| topic | dexmedetomidine adjuvant cardioprotection α2-adrenergic receptors agonists sympatholysis extracorporeal circulation complications of cardiac surgery |
| url | https://www.reanimatology.com/rmt/article/view/1603 |
| work_keys_str_mv | AT iakozlov dexmedetomidineasacardioprotectorincardiacsurgeryreview AT tvklypa dexmedetomidineasacardioprotectorincardiacsurgeryreview AT ioantonov dexmedetomidineasacardioprotectorincardiacsurgeryreview |