Kir6.2 channel activity is regulated by interaction of transmembrane domains 1 and 2 through I167 in the bundle‐crossing gate

Kir6.2 channel activity is regulated by interaction of transmembrane domains 1 and 2 through I167 in the bundle‐crossing gate

Abstract ATP‐sensitive potassium (KATP) channel in pancreatic β‐cells is composed of four pore‐forming inward rectifier potassium (Kir) 6.2 subunits and four regulatory sulfonylurea receptor (SUR) 1 subunits and regulate insulin secretion. Kir6.2 consists of a N‐terminal region, an outer transmembra...

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Main Authors: Ryoko Kawashima, Charlotte Meller, Manabu Suzuki, Shigeki Kato, Shoichiro Horita, Shizu Hidema, Shingen Misaka, Mitsuaki Hosoya, Hayato Go, Kazuto Kobayashi, Heidi deWet, Yuko Maejima, Kenju Shimomura
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Physiological Reports
Subjects:
KATP channel
Kir6.2
SUR
Online Access:https://doi.org/10.14814/phy2.70481
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