Quantitative light-induced fluorescence-guided surgery for medication-related osteomyelitis of the jaw
Background: Medication-related osteonecrosis of the jaw (MRONJ) is a challenging condition with increasing incidence, and the lack of clear surgical guidelines poses difficulties in its treatment. Methods: Quantitative light-induced fluorescence (QLF), which can distinguish between vital and necroti...
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Elsevier
2024-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S157210002300594X |
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| author | Yesel Kim Jeong-Kui Ku |
| author_facet | Yesel Kim Jeong-Kui Ku |
| author_sort | Yesel Kim |
| collection | DOAJ |
| description | Background: Medication-related osteonecrosis of the jaw (MRONJ) is a challenging condition with increasing incidence, and the lack of clear surgical guidelines poses difficulties in its treatment. Methods: Quantitative light-induced fluorescence (QLF), which can distinguish between vital and necrotic bone tissue without the need for additional markers, was used to guide minimally invasive surgery in a 75-year-old patient with MRONJ. Results: This study demonstrated that QLF allows the real-time identification of infected and necrotic bone tissue during surgery, enabling precise and minimally invasive resection. We observed spontaneous bone recovery and remodeling in sclerotic bone areas that exhibited autofluorescence using a QLF device, suggesting its potential for preserving the bone tissue. Conclusion: This study highlights the promising application of QLF as a valuable photodiagnostic tool in MRONJ surgery, offering a noninvasive and intraoperative device for differentiating pathological bone tissue. This approach can potentially improve the precision of surgical interventions and contribute to improved patient outcomes in MRONJ management. |
| format | Article |
| id | doaj-art-a8b73c332e494ec1b65bcaee4d8ea693 |
| institution | OA Journals |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-a8b73c332e494ec1b65bcaee4d8ea6932025-08-20T02:38:59ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-02-014510386710.1016/j.pdpdt.2023.103867Quantitative light-induced fluorescence-guided surgery for medication-related osteomyelitis of the jawYesel Kim0Jeong-Kui Ku1Department of Dental Hygiene, Jeonju Kijeon College, Jeonju 54989, Republic of KoreaDepartment of Oral and Maxillofacial Surgery, School of Dentistry and Institute of Oral Bioscience, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University, Jeonju 54907, Republic of Korea; Corresponding author.Background: Medication-related osteonecrosis of the jaw (MRONJ) is a challenging condition with increasing incidence, and the lack of clear surgical guidelines poses difficulties in its treatment. Methods: Quantitative light-induced fluorescence (QLF), which can distinguish between vital and necrotic bone tissue without the need for additional markers, was used to guide minimally invasive surgery in a 75-year-old patient with MRONJ. Results: This study demonstrated that QLF allows the real-time identification of infected and necrotic bone tissue during surgery, enabling precise and minimally invasive resection. We observed spontaneous bone recovery and remodeling in sclerotic bone areas that exhibited autofluorescence using a QLF device, suggesting its potential for preserving the bone tissue. Conclusion: This study highlights the promising application of QLF as a valuable photodiagnostic tool in MRONJ surgery, offering a noninvasive and intraoperative device for differentiating pathological bone tissue. This approach can potentially improve the precision of surgical interventions and contribute to improved patient outcomes in MRONJ management.http://www.sciencedirect.com/science/article/pii/S157210002300594XDentistryMinimally invasive surgeryOsteomyelitisOsteonecrosis of the jawQuantitative light-induced fluorescence |
| spellingShingle | Yesel Kim Jeong-Kui Ku Quantitative light-induced fluorescence-guided surgery for medication-related osteomyelitis of the jaw Photodiagnosis and Photodynamic Therapy Dentistry Minimally invasive surgery Osteomyelitis Osteonecrosis of the jaw Quantitative light-induced fluorescence |
| title | Quantitative light-induced fluorescence-guided surgery for medication-related osteomyelitis of the jaw |
| title_full | Quantitative light-induced fluorescence-guided surgery for medication-related osteomyelitis of the jaw |
| title_fullStr | Quantitative light-induced fluorescence-guided surgery for medication-related osteomyelitis of the jaw |
| title_full_unstemmed | Quantitative light-induced fluorescence-guided surgery for medication-related osteomyelitis of the jaw |
| title_short | Quantitative light-induced fluorescence-guided surgery for medication-related osteomyelitis of the jaw |
| title_sort | quantitative light induced fluorescence guided surgery for medication related osteomyelitis of the jaw |
| topic | Dentistry Minimally invasive surgery Osteomyelitis Osteonecrosis of the jaw Quantitative light-induced fluorescence |
| url | http://www.sciencedirect.com/science/article/pii/S157210002300594X |
| work_keys_str_mv | AT yeselkim quantitativelightinducedfluorescenceguidedsurgeryformedicationrelatedosteomyelitisofthejaw AT jeongkuiku quantitativelightinducedfluorescenceguidedsurgeryformedicationrelatedosteomyelitisofthejaw |