Nanogenerator Neuromodulation to Enable Locomotion Rehabilitation for Spinal Cord Injury via Epidural Electrical Stimulation
Abstract Spinal cord injury (SCI) is a severe neurological disease, often accompanied by impaired lower limb motor function and muscle atrophy. Epidural electrical stimulation (EES) has been demonstrated promising for SCI therapy in ways of rehabilitation by facilitating the recovery of lower limb m...
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Wiley
2025-06-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202501425 |
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| author | Cong Li Yizhu Shan Shihao Zheng Puchuan Tan Yuan Bai Engui Wang Lingling Xu Ruizeng Luo Shengyu Chao Jing Huang Pengyu Ren Zhou Li Hongqing Feng |
| author_facet | Cong Li Yizhu Shan Shihao Zheng Puchuan Tan Yuan Bai Engui Wang Lingling Xu Ruizeng Luo Shengyu Chao Jing Huang Pengyu Ren Zhou Li Hongqing Feng |
| author_sort | Cong Li |
| collection | DOAJ |
| description | Abstract Spinal cord injury (SCI) is a severe neurological disease, often accompanied by impaired lower limb motor function and muscle atrophy. Epidural electrical stimulation (EES) has been demonstrated promising for SCI therapy in ways of rehabilitation by facilitating the recovery of lower limb motor abilities. However, EES necessitates a considerable consumption of electrical energy and exhibits large individual differences in treatment. Nanogenerators (NGs) based on a novel power generation technology, are capable of transforming mechanical energy into electrical power. This mechanic‐driven electrical stimulation has been reported effective in several types of neuromodulations, but not in EES to enable SCI rehabilitation. This study explores the efficacy of a hybrid‐NG (H‐NG) to elicit hindlimb locomotion in rats via EES on the spinal cord, in comparison with a commercial stimulus generator (SG). The results reveal that H‐NG can activate the spinal cord and induce hindlimb locomotion with much lower electrical parameters and much smaller individual differences than SG. In addition, benefiting from the miniature size of the H‐NG, an implantable EES system is constructed in vivo, enabling a self‐driven and rational‐controlled EES pattern. The proposed H‐NG‐based EES system provides a new strategy for optimized and personalized treatment for SCI patients. |
| format | Article |
| id | doaj-art-a8b63f7dbbe04d07b1cc79efbc39e84e |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-a8b63f7dbbe04d07b1cc79efbc39e84e2025-08-20T03:29:52ZengWileyAdvanced Science2198-38442025-06-011224n/an/a10.1002/advs.202501425Nanogenerator Neuromodulation to Enable Locomotion Rehabilitation for Spinal Cord Injury via Epidural Electrical StimulationCong Li0Yizhu Shan1Shihao Zheng2Puchuan Tan3Yuan Bai4Engui Wang5Lingling Xu6Ruizeng Luo7Shengyu Chao8Jing Huang9Pengyu Ren10Zhou Li11Hongqing Feng12Department of Neurosurgery Second Affiliated Hospital of Xi'an Jiao Tong University Xi'an Shaanxi 710004 ChinaBeijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 ChinaCollege of Materials Science and Opto‐Electronic Technology University of Chinese Academy of Sciences Beijing 101400 ChinaBeijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 ChinaBeijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 ChinaBeijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 ChinaBeijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 ChinaBeijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 ChinaBeijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 ChinaBeijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 ChinaDepartment of Neurosurgery Second Affiliated Hospital of Xi'an Jiao Tong University Xi'an Shaanxi 710004 ChinaBeijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 ChinaCollege of Materials Science and Opto‐Electronic Technology University of Chinese Academy of Sciences Beijing 101400 ChinaAbstract Spinal cord injury (SCI) is a severe neurological disease, often accompanied by impaired lower limb motor function and muscle atrophy. Epidural electrical stimulation (EES) has been demonstrated promising for SCI therapy in ways of rehabilitation by facilitating the recovery of lower limb motor abilities. However, EES necessitates a considerable consumption of electrical energy and exhibits large individual differences in treatment. Nanogenerators (NGs) based on a novel power generation technology, are capable of transforming mechanical energy into electrical power. This mechanic‐driven electrical stimulation has been reported effective in several types of neuromodulations, but not in EES to enable SCI rehabilitation. This study explores the efficacy of a hybrid‐NG (H‐NG) to elicit hindlimb locomotion in rats via EES on the spinal cord, in comparison with a commercial stimulus generator (SG). The results reveal that H‐NG can activate the spinal cord and induce hindlimb locomotion with much lower electrical parameters and much smaller individual differences than SG. In addition, benefiting from the miniature size of the H‐NG, an implantable EES system is constructed in vivo, enabling a self‐driven and rational‐controlled EES pattern. The proposed H‐NG‐based EES system provides a new strategy for optimized and personalized treatment for SCI patients.https://doi.org/10.1002/advs.202501425epidural electrical stimulationnanogeneratorneuromodulationrehabilitationspinal cord injury |
| spellingShingle | Cong Li Yizhu Shan Shihao Zheng Puchuan Tan Yuan Bai Engui Wang Lingling Xu Ruizeng Luo Shengyu Chao Jing Huang Pengyu Ren Zhou Li Hongqing Feng Nanogenerator Neuromodulation to Enable Locomotion Rehabilitation for Spinal Cord Injury via Epidural Electrical Stimulation Advanced Science epidural electrical stimulation nanogenerator neuromodulation rehabilitation spinal cord injury |
| title | Nanogenerator Neuromodulation to Enable Locomotion Rehabilitation for Spinal Cord Injury via Epidural Electrical Stimulation |
| title_full | Nanogenerator Neuromodulation to Enable Locomotion Rehabilitation for Spinal Cord Injury via Epidural Electrical Stimulation |
| title_fullStr | Nanogenerator Neuromodulation to Enable Locomotion Rehabilitation for Spinal Cord Injury via Epidural Electrical Stimulation |
| title_full_unstemmed | Nanogenerator Neuromodulation to Enable Locomotion Rehabilitation for Spinal Cord Injury via Epidural Electrical Stimulation |
| title_short | Nanogenerator Neuromodulation to Enable Locomotion Rehabilitation for Spinal Cord Injury via Epidural Electrical Stimulation |
| title_sort | nanogenerator neuromodulation to enable locomotion rehabilitation for spinal cord injury via epidural electrical stimulation |
| topic | epidural electrical stimulation nanogenerator neuromodulation rehabilitation spinal cord injury |
| url | https://doi.org/10.1002/advs.202501425 |
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