Uric acid and skeletal muscle status in females with rheumatoid arthritis
Aim. To study the association of uric acid (UA) levels with skeletal muscle mass, strength and physical performance in women with rheumatoid arthritis (RA). Materials and methods. One hundred thirty women (median age 61 [53; 66] years) with confirmed RA who signed informed consent were examined....
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2025-01-01
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| Series: | Терапевтический архив |
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| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/655487/198214 |
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| author | Olga V. Dobrovolskaya Maria V. Kozyreva Nikolay V. Demin Natalia V. Toroptsova |
| author_facet | Olga V. Dobrovolskaya Maria V. Kozyreva Nikolay V. Demin Natalia V. Toroptsova |
| author_sort | Olga V. Dobrovolskaya |
| collection | DOAJ |
| description | Aim. To study the association of uric acid (UA) levels with skeletal muscle mass, strength and physical performance in women with rheumatoid arthritis (RA).
Materials and methods. One hundred thirty women (median age 61 [53; 66] years) with confirmed RA who signed informed consent were examined. A clinical and laboratory examination was performed, including an assessment of muscle strength, physical performance. Dual-energy X-ray absorptiometry according to the “whole body” program was done.
Results. The median UA level was 262.8 [197.4; 310.5] μmol/l, the incidence of hyperuricemia was 9.2%. Positive correlations of UA with the total lean mass index (r=0.32; p0.001), appendicular lean mass index (r=0.24; p=0.006) were established. These associations were confirmed in multiple linear regression analysis (b*=0.38; p0.001 and b*=0.29; p0.001, respectively). There was no association between the level of UA and RA parameters (duration of the disease, glucocorticoid intake, RF and ACCP seropositivity, ESR, CRP and DAS-28 index), as well as with muscle strength. A negative correlation between the level of UA and parameters of physical performance was found.
Conclusion. The frequency of hyperuricemia was 9.2% in women with RA. Multiple regression analysis confirmed an independent association between lean mass and UA level. |
| format | Article |
| id | doaj-art-a8b1ffa6f63945f7863aa0c5bb5590dc |
| institution | Kabale University |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| publishDate | 2025-01-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj-art-a8b1ffa6f63945f7863aa0c5bb5590dc2025-08-20T03:29:43Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422025-01-0197542743310.26442/00403660.2025.05.20321578675Uric acid and skeletal muscle status in females with rheumatoid arthritisOlga V. Dobrovolskaya0https://orcid.org/0000-0002-2809-0197Maria V. Kozyreva1https://orcid.org/0000-0003-0560-3495Nikolay V. Demin2https://orcid.org/0000-0003-0961-9785Natalia V. Toroptsova3https://orcid.org/0000-0003-4739-4302Nasonova Research Institute of RheumatologyNasonova Research Institute of RheumatologyNasonova Research Institute of RheumatologyNasonova Research Institute of RheumatologyAim. To study the association of uric acid (UA) levels with skeletal muscle mass, strength and physical performance in women with rheumatoid arthritis (RA). Materials and methods. One hundred thirty women (median age 61 [53; 66] years) with confirmed RA who signed informed consent were examined. A clinical and laboratory examination was performed, including an assessment of muscle strength, physical performance. Dual-energy X-ray absorptiometry according to the “whole body” program was done. Results. The median UA level was 262.8 [197.4; 310.5] μmol/l, the incidence of hyperuricemia was 9.2%. Positive correlations of UA with the total lean mass index (r=0.32; p0.001), appendicular lean mass index (r=0.24; p=0.006) were established. These associations were confirmed in multiple linear regression analysis (b*=0.38; p0.001 and b*=0.29; p0.001, respectively). There was no association between the level of UA and RA parameters (duration of the disease, glucocorticoid intake, RF and ACCP seropositivity, ESR, CRP and DAS-28 index), as well as with muscle strength. A negative correlation between the level of UA and parameters of physical performance was found. Conclusion. The frequency of hyperuricemia was 9.2% in women with RA. Multiple regression analysis confirmed an independent association between lean mass and UA level.https://ter-arkhiv.ru/0040-3660/article/viewFile/655487/198214rheumatoid arthritisuric acidhyperuricemiasarcopeniamuscle quality indexlean massphysical performance |
| spellingShingle | Olga V. Dobrovolskaya Maria V. Kozyreva Nikolay V. Demin Natalia V. Toroptsova Uric acid and skeletal muscle status in females with rheumatoid arthritis Терапевтический архив rheumatoid arthritis uric acid hyperuricemia sarcopenia muscle quality index lean mass physical performance |
| title | Uric acid and skeletal muscle status in females with rheumatoid arthritis |
| title_full | Uric acid and skeletal muscle status in females with rheumatoid arthritis |
| title_fullStr | Uric acid and skeletal muscle status in females with rheumatoid arthritis |
| title_full_unstemmed | Uric acid and skeletal muscle status in females with rheumatoid arthritis |
| title_short | Uric acid and skeletal muscle status in females with rheumatoid arthritis |
| title_sort | uric acid and skeletal muscle status in females with rheumatoid arthritis |
| topic | rheumatoid arthritis uric acid hyperuricemia sarcopenia muscle quality index lean mass physical performance |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/655487/198214 |
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