The role and therapeutic targeting of the CCL2/CCR2 signaling axis in inflammatory and fibrotic diseases

The role and therapeutic targeting of the CCL2/CCR2 signaling axis in inflammatory and fibrotic diseases

CCL2, a pivotal cytokine within the chemokine family, functions by binding to its receptor CCR2. The CCL2/CCR2 signaling pathway plays a crucial role in the development of fibrosis across multiple organ systems by modulating the recruitment and activation of immune cells, which in turn influences th...

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Bibliographic Details
Main Authors: Shan Guo, Qi Zhang, Yingjie Guo, Xiaoyan Yin, Peng Zhang, Tao Mao, Zibin Tian, Xiaoyu Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
CCL2
CCR2
inflammation
fibrosis
immune regulation
clinical diagnosis and treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1497026/full
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