Metal Allergy and Systemic Contact Dermatitis: An Overview
Contact dermatitis is produced by external skin exposure to an allergen, but sometimes a systemically administered allergen may reach the skin and remain concentrated there with the aid of the circulatory system, leading to the production of systemic contact dermatitis (SCD). Metals such as nickel,...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/749561 |
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| author | Yoko Yoshihisa Tadamichi Shimizu |
| author_facet | Yoko Yoshihisa Tadamichi Shimizu |
| author_sort | Yoko Yoshihisa |
| collection | DOAJ |
| description | Contact dermatitis is produced by external skin exposure to an allergen, but sometimes a systemically administered allergen may reach the skin and remain concentrated there with the aid of the circulatory system, leading to the production of systemic contact dermatitis (SCD). Metals such as nickel, cobalt, chromium, and zinc are ubiquitous in our environment. Metal allergy may result in allergic contact dermatitis and also SCD. Systemic reactions, such as hand dermatitis or generalized eczematous reactions, can occur due to dietary nickel or cobalt ingestion. Zinc-containing dental fillings can induce oral lichen planus, palmoplantar pustulosis, and maculopapular rash. A diagnosis of sensitivity to metal is established by epicutaneous patch testing and oral metal challenge with metals such as nickel, cobalt, chromium, and zinc. In vitro tests, such as the lymphocyte stimulating test (LST), have some advantages over patch testing to diagnose allergic contact dermatitis. Additionally, the determination of the production of several cytokines by primary peripheral blood mononuclear cell cultures is a potentially promising in vitro method for the discrimination of metal allergies, including SCD, as compared with the LST. |
| format | Article |
| id | doaj-art-a8acf206b1ce4b239ac437d0f16e4eea |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-a8acf206b1ce4b239ac437d0f16e4eea2025-08-20T03:39:09ZengWileyDermatology Research and Practice1687-61051687-61132012-01-01201210.1155/2012/749561749561Metal Allergy and Systemic Contact Dermatitis: An OverviewYoko Yoshihisa0Tadamichi Shimizu1Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, JapanDepartment of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, JapanContact dermatitis is produced by external skin exposure to an allergen, but sometimes a systemically administered allergen may reach the skin and remain concentrated there with the aid of the circulatory system, leading to the production of systemic contact dermatitis (SCD). Metals such as nickel, cobalt, chromium, and zinc are ubiquitous in our environment. Metal allergy may result in allergic contact dermatitis and also SCD. Systemic reactions, such as hand dermatitis or generalized eczematous reactions, can occur due to dietary nickel or cobalt ingestion. Zinc-containing dental fillings can induce oral lichen planus, palmoplantar pustulosis, and maculopapular rash. A diagnosis of sensitivity to metal is established by epicutaneous patch testing and oral metal challenge with metals such as nickel, cobalt, chromium, and zinc. In vitro tests, such as the lymphocyte stimulating test (LST), have some advantages over patch testing to diagnose allergic contact dermatitis. Additionally, the determination of the production of several cytokines by primary peripheral blood mononuclear cell cultures is a potentially promising in vitro method for the discrimination of metal allergies, including SCD, as compared with the LST.http://dx.doi.org/10.1155/2012/749561 |
| spellingShingle | Yoko Yoshihisa Tadamichi Shimizu Metal Allergy and Systemic Contact Dermatitis: An Overview Dermatology Research and Practice |
| title | Metal Allergy and Systemic Contact Dermatitis: An Overview |
| title_full | Metal Allergy and Systemic Contact Dermatitis: An Overview |
| title_fullStr | Metal Allergy and Systemic Contact Dermatitis: An Overview |
| title_full_unstemmed | Metal Allergy and Systemic Contact Dermatitis: An Overview |
| title_short | Metal Allergy and Systemic Contact Dermatitis: An Overview |
| title_sort | metal allergy and systemic contact dermatitis an overview |
| url | http://dx.doi.org/10.1155/2012/749561 |
| work_keys_str_mv | AT yokoyoshihisa metalallergyandsystemiccontactdermatitisanoverview AT tadamichishimizu metalallergyandsystemiccontactdermatitisanoverview |