Serum uric acid to high-density lipoprotein cholesterol ratio predicts all-cause mortality in adults with metabolic dysfunction associated steatotic liver disease
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most prevalent chronic metabolic diseases worldwide. While serum uric acid (SUA) and high-density lipoprotein cholesterol (HDL) are individually associated with the development of MASLD, the prognostic effect of...
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Nature Portfolio
2025-04-01
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| Online Access: | https://doi.org/10.1038/s41598-025-94651-5 |
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| author | Yingyong Ou Zihan Qin Pinze Wang Fan Zou |
| author_facet | Yingyong Ou Zihan Qin Pinze Wang Fan Zou |
| author_sort | Yingyong Ou |
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| description | Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most prevalent chronic metabolic diseases worldwide. While serum uric acid (SUA) and high-density lipoprotein cholesterol (HDL) are individually associated with the development of MASLD, the prognostic effect of the UA, HDL and SUA-to-HDL ratio (UHR) on the all-cause mortality of MASLD patients remains unexplored. This study utilized data from 4280 MASLD patients in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. UHR was calculated by dividing SUA by HDL, and its association with all-cause mortality was assessed using Cox proportional hazards models. Adjustments were made for demographic, lifestyle, and clinical factors. A one-standard-deviation increase in UA or UHR was associated with a 19% (HR 1.19, 95% CI 1.08–1.31, P < 0.001) or 18% (HR 1.18; 95% CI 1.07–1.30; P < 0.001) higher risk of all-cause mortality of MASLD participants respectively, while no association was found between HDL and mortality. SUA and UHR are promising predictors of all-cause mortality in MASLD patients, offering clinicians a valuable biomarker for related risk stratification. Its inclusion in clinical assessments could guide interventions and improve prognosis, advancing management for MASLD patients. |
| format | Article |
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| institution | OA Journals |
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| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-a8ac24acb13a4955bfda3cf3495f7db42025-08-20T01:54:23ZengNature PortfolioScientific Reports2045-23222025-04-0115111010.1038/s41598-025-94651-5Serum uric acid to high-density lipoprotein cholesterol ratio predicts all-cause mortality in adults with metabolic dysfunction associated steatotic liver diseaseYingyong Ou0Zihan Qin1Pinze Wang2Fan Zou3Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Zunyi Medical UniversityHebei Medical UniversityHebei Medical UniversityDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Zunyi Medical UniversityAbstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most prevalent chronic metabolic diseases worldwide. While serum uric acid (SUA) and high-density lipoprotein cholesterol (HDL) are individually associated with the development of MASLD, the prognostic effect of the UA, HDL and SUA-to-HDL ratio (UHR) on the all-cause mortality of MASLD patients remains unexplored. This study utilized data from 4280 MASLD patients in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. UHR was calculated by dividing SUA by HDL, and its association with all-cause mortality was assessed using Cox proportional hazards models. Adjustments were made for demographic, lifestyle, and clinical factors. A one-standard-deviation increase in UA or UHR was associated with a 19% (HR 1.19, 95% CI 1.08–1.31, P < 0.001) or 18% (HR 1.18; 95% CI 1.07–1.30; P < 0.001) higher risk of all-cause mortality of MASLD participants respectively, while no association was found between HDL and mortality. SUA and UHR are promising predictors of all-cause mortality in MASLD patients, offering clinicians a valuable biomarker for related risk stratification. Its inclusion in clinical assessments could guide interventions and improve prognosis, advancing management for MASLD patients.https://doi.org/10.1038/s41598-025-94651-5Metabolic dysfunction-associated steatotic liver diseaseSerum uric acidHigh-density lipoprotein cholesterolSerum uric acid-to-high-density lipoprotein cholesterol ratioAll-cause mortalityNHANES |
| spellingShingle | Yingyong Ou Zihan Qin Pinze Wang Fan Zou Serum uric acid to high-density lipoprotein cholesterol ratio predicts all-cause mortality in adults with metabolic dysfunction associated steatotic liver disease Scientific Reports Metabolic dysfunction-associated steatotic liver disease Serum uric acid High-density lipoprotein cholesterol Serum uric acid-to-high-density lipoprotein cholesterol ratio All-cause mortality NHANES |
| title | Serum uric acid to high-density lipoprotein cholesterol ratio predicts all-cause mortality in adults with metabolic dysfunction associated steatotic liver disease |
| title_full | Serum uric acid to high-density lipoprotein cholesterol ratio predicts all-cause mortality in adults with metabolic dysfunction associated steatotic liver disease |
| title_fullStr | Serum uric acid to high-density lipoprotein cholesterol ratio predicts all-cause mortality in adults with metabolic dysfunction associated steatotic liver disease |
| title_full_unstemmed | Serum uric acid to high-density lipoprotein cholesterol ratio predicts all-cause mortality in adults with metabolic dysfunction associated steatotic liver disease |
| title_short | Serum uric acid to high-density lipoprotein cholesterol ratio predicts all-cause mortality in adults with metabolic dysfunction associated steatotic liver disease |
| title_sort | serum uric acid to high density lipoprotein cholesterol ratio predicts all cause mortality in adults with metabolic dysfunction associated steatotic liver disease |
| topic | Metabolic dysfunction-associated steatotic liver disease Serum uric acid High-density lipoprotein cholesterol Serum uric acid-to-high-density lipoprotein cholesterol ratio All-cause mortality NHANES |
| url | https://doi.org/10.1038/s41598-025-94651-5 |
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