Development of the TSR-based computational method to investigate spike and monoclonal antibody interactions

Development of the TSR-based computational method to investigate spike and monoclonal antibody interactions

IntroductionMonoclonal antibody (mAb) drug treatments have proven effective in reducing COVID-19-related hospitalizations or fatalities, particularly among high-risk patients. Numerous experimental studies have explored the structures of spike proteins and their complexes with ACE2 or mAbs. These 3D...

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Bibliographic Details
Main Authors: Tarikul I. Milon, Titli Sarkar, Yixin Chen, Jordan M. Grider, Feng Chen, Jun-Yuan Ji, Seetharama D. Jois, Konstantin G. Kousoulas, Vijay Raghavan, Wu Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Chemistry
Subjects:
TSR-based method
molecular interaction
monoclonal antibody
spike
amino acid structure
machine learning
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2025.1395374/full
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