miR-370-3p affects the progression of postmenopausal osteoporosis through targeting INO80
Abstract Background Postmenopausal osteoporosis (PMO) is acknowledged as a principal category of osteoporosis (OP). The aim of this study was to investigate the level of miR-370-3p in PMO patients and its predictive effect on osteoporosis in postmenopausal women, and to explore the molecular mechani...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
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| Series: | Hereditas |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41065-025-00502-8 |
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| Summary: | Abstract Background Postmenopausal osteoporosis (PMO) is acknowledged as a principal category of osteoporosis (OP). The aim of this study was to investigate the level of miR-370-3p in PMO patients and its predictive effect on osteoporosis in postmenopausal women, and to explore the molecular mechanism of miR-370-3p on PMO. Methods The expression of miR-370-3p was assessed using RT-qPCR. Cell proliferation of MC3T3-E1 cells was evaluated through CCK-8 assays. Cell apoptosis was detected by flow cytometry. The direct interaction between miR-370-3p and INO80 was confirmed via dual-luciferase reporter assays. Results The level of miR-370-3p was found to be upregulated in osteoporosis patients, and miR-370-3p played a significant role in regulating the proliferation, apoptosis and differentiation of osteoblasts. In addition, miR-370-3p targeted INO80 and affected the disease progression of PMO. Conclusions miR-370-3p/INO80 may serve as a promising biomarker for both the diagnosis and therapeutic management of PMO. |
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| ISSN: | 1601-5223 |