Stromal PLAU mediates tumor progression and informs a novel therapeutic target in triple-negative breast cancer

Stromal PLAU mediates tumor progression and informs a novel therapeutic target in triple-negative breast cancer

Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by limited treatment options and poor prognosis. Recent evidence highlights the crucial role of cancer-associated fibroblasts (CAFs) in TNBC progression, yet their molecular characteristics remain incompletely under...

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Bibliographic Details
Main Authors: Jun Zou, Jingyao Zhang, Yu Li, Baowen Yuan, Yuanyi Wang, Yalong Qi, Qian Wang, Wan Qin, Xianglin Yuan, Binghe Xu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cancer Cell International
Subjects:
TNBC
Cancer-associated fibroblasts
Prognostic signature
PLAU
Tumor microenvironment
Online Access:https://doi.org/10.1186/s12935-025-03867-y
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