Dosage Optimization for Letrozole Treatment in Clomiphene-Resistant Patients with Polycystic Ovary Syndrome: A Prospective Interventional Study
Objective. Dose adjustment for induction of ovulation is one of the most important problem. Methods. In a prospective interventional study, 44 clomiphene-resistant infertile patients (113 cycles) were selected from the Abolfazl Infertility Clinic of Bushehr University of Medical Sciences. Letrozole...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2012/758508 |
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| _version_ | 1850169380895195136 |
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| author | Elham Rahmani Shahnaz Ahmadi Niloofar Motamed Hesam_Oddin Maneshi |
| author_facet | Elham Rahmani Shahnaz Ahmadi Niloofar Motamed Hesam_Oddin Maneshi |
| author_sort | Elham Rahmani |
| collection | DOAJ |
| description | Objective. Dose adjustment for induction of ovulation is one of the most important problem. Methods. In a prospective interventional study, 44 clomiphene-resistant infertile patients (113 cycles) were selected from the Abolfazl Infertility Clinic of Bushehr University of Medical Sciences. Letrozole was given orally in a dose of 2.5 mg, 5 mg, and 7.5 mg, respectively. If the patient displayed no response, the dosage was increased. Results. In this patients ovulation occurred in 50 cycles (44.24%), clinical pregnancy rate according to number of cycles was 23.89% (27 of 113 cycles) and according to the number of patients was 61.36% (27 of 44 patients). In the 2.5, 5, and 7.5 groups, follicles occurred in 22.9%, 42.1%, and 85.18% of cycles, and pregnancy rate was 14.58%, 28.94% and, 33.33%, respectively. Conclusions. It is better to administer Letrozole at a lower dosage to prevent complications and increase the dose based on sonographic results antral follicular count, anti-Müllerian hormone, LH/FSH, and estradiol. |
| format | Article |
| id | doaj-art-a89475c0126441f982bb26b72aa1083f |
| institution | OA Journals |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-a89475c0126441f982bb26b72aa1083f2025-08-20T02:20:44ZengWileyObstetrics and Gynecology International1687-95891687-95972012-01-01201210.1155/2012/758508758508Dosage Optimization for Letrozole Treatment in Clomiphene-Resistant Patients with Polycystic Ovary Syndrome: A Prospective Interventional StudyElham Rahmani0Shahnaz Ahmadi1Niloofar Motamed2Hesam_Oddin Maneshi3School of Medicine, Bushehr University of Medical Sciences, Moallem Street, Bushehr, IranSchool of Medicine, Bushehr University of Medical Sciences, Moallem Street, Bushehr, IranSchool of Medicine, Bushehr University of Medical Sciences, Moallem Street, Bushehr, IranSchool of Medicine, Bushehr University of Medical Sciences, Moallem Street, Bushehr, IranObjective. Dose adjustment for induction of ovulation is one of the most important problem. Methods. In a prospective interventional study, 44 clomiphene-resistant infertile patients (113 cycles) were selected from the Abolfazl Infertility Clinic of Bushehr University of Medical Sciences. Letrozole was given orally in a dose of 2.5 mg, 5 mg, and 7.5 mg, respectively. If the patient displayed no response, the dosage was increased. Results. In this patients ovulation occurred in 50 cycles (44.24%), clinical pregnancy rate according to number of cycles was 23.89% (27 of 113 cycles) and according to the number of patients was 61.36% (27 of 44 patients). In the 2.5, 5, and 7.5 groups, follicles occurred in 22.9%, 42.1%, and 85.18% of cycles, and pregnancy rate was 14.58%, 28.94% and, 33.33%, respectively. Conclusions. It is better to administer Letrozole at a lower dosage to prevent complications and increase the dose based on sonographic results antral follicular count, anti-Müllerian hormone, LH/FSH, and estradiol.http://dx.doi.org/10.1155/2012/758508 |
| spellingShingle | Elham Rahmani Shahnaz Ahmadi Niloofar Motamed Hesam_Oddin Maneshi Dosage Optimization for Letrozole Treatment in Clomiphene-Resistant Patients with Polycystic Ovary Syndrome: A Prospective Interventional Study Obstetrics and Gynecology International |
| title | Dosage Optimization for Letrozole Treatment in Clomiphene-Resistant Patients with Polycystic Ovary Syndrome: A Prospective Interventional Study |
| title_full | Dosage Optimization for Letrozole Treatment in Clomiphene-Resistant Patients with Polycystic Ovary Syndrome: A Prospective Interventional Study |
| title_fullStr | Dosage Optimization for Letrozole Treatment in Clomiphene-Resistant Patients with Polycystic Ovary Syndrome: A Prospective Interventional Study |
| title_full_unstemmed | Dosage Optimization for Letrozole Treatment in Clomiphene-Resistant Patients with Polycystic Ovary Syndrome: A Prospective Interventional Study |
| title_short | Dosage Optimization for Letrozole Treatment in Clomiphene-Resistant Patients with Polycystic Ovary Syndrome: A Prospective Interventional Study |
| title_sort | dosage optimization for letrozole treatment in clomiphene resistant patients with polycystic ovary syndrome a prospective interventional study |
| url | http://dx.doi.org/10.1155/2012/758508 |
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