Cryptosporidium spp. in Argentina: epidemiology and research advances in human, animal, and environmental settings during the 21st century

IntroductionCryptosporidium spp. is an intestinal protozoan causing cryptosporidiosis, a diarrheal disease affecting humans and animals, with zoonotic potential. In immunocompromised individuals, infections can be severe or fatal. It is a major waterborne parasite and a leading cause of neonatal dia...

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Main Authors: Maria Romina Rivero, Claudina Vissio, Constanza Feliziani, Carlos De Angelo, Maria Carolina Touz, Karina Tiranti, Joaquín Andrés Lombardelli, Florencia Judith Duartez, Lumila Curletto
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Microbiology
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Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1592564/full
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author Maria Romina Rivero
Claudina Vissio
Constanza Feliziani
Carlos De Angelo
Maria Carolina Touz
Karina Tiranti
Joaquín Andrés Lombardelli
Florencia Judith Duartez
Lumila Curletto
author_facet Maria Romina Rivero
Claudina Vissio
Constanza Feliziani
Carlos De Angelo
Maria Carolina Touz
Karina Tiranti
Joaquín Andrés Lombardelli
Florencia Judith Duartez
Lumila Curletto
author_sort Maria Romina Rivero
collection DOAJ
description IntroductionCryptosporidium spp. is an intestinal protozoan causing cryptosporidiosis, a diarrheal disease affecting humans and animals, with zoonotic potential. In immunocompromised individuals, infections can be severe or fatal. It is a major waterborne parasite and a leading cause of neonatal diarrhea in calves. This study systematically reviews Cryptosporidium spp. research in Argentina during the 21st century, highlighting its epidemiological significance and research gaps.MethodsA systematic review following PRISMA guidelines was conducted using LILACS, PubMed, Scopus, and SciELO Argentina. Eligible studies (2001–2024) included human (community and hospital-based), animal (domestic, wild, and captive), and environmental (water, soil and vegetable) surveys. The review analyzed epidemiology, diagnosis, treatment, genetic diversity, distribution, and risk factors.ResultsOf 277 articles reviewed, 66 met eligibility criteria. Cryptosporidium spp. was detected in 17 of Argentina’s 23 provinces, mainly in the Pampean region. Five species were identified (C. hominis, C. parvum, C. suis, C. scrofarum, and C. varanii), though genetic diversity studies remain limited. Human cryptosporidiosis primarily affects immunocompromised individuals (HIV/AIDS, transplant recipients, hematologic cancer patients). The parasite was found in feces, duodenal biopsies, blood, sputum, and cerebrospinal fluid, with complications such as cholangiopathy and pulmonary cryptosporidiosis. Infections with C. hominis and C. parvum (including co-infections) were observed, with multiple subtypes documented. In animals, C. parvum was prevalent in Pampean calves, while C. suis and C. scrofarum were found in domestic pigs. Wildlife, including non-human primates and coypu, also tested positive. Cryptosporidium was detected in recreational and drinking water samples. No Cryptosporidium spp. oocysts were detected in soil. Risk factors included socio-economic conditions and animal management practices.ConclusionCryptosporidium spp. is widely distributed in Argentina, yet eco-epidemiological transmission factors remain poorly understood, hindering control strategies. Limited research on genetic diversity and distribution highlights the need for further studies, particularly in vulnerable populations and areas of close human-animal interaction, such as productive systems. The presence of Cryptosporidium spp. in water underscores the importance of improving public health policies and water treatment standards. From a One Health perspective, these findings emphasize the need for enhanced epidemiological surveillance and research to strengthen prevention and control in Argentina.
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spelling doaj-art-a884eb5e60714e6a85d104c160eb13eb2025-08-20T03:12:31ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-05-011610.3389/fmicb.2025.15925641592564Cryptosporidium spp. in Argentina: epidemiology and research advances in human, animal, and environmental settings during the 21st centuryMaria Romina Rivero0Claudina Vissio1Constanza Feliziani2Carlos De Angelo3Maria Carolina Touz4Karina Tiranti5Joaquín Andrés Lombardelli6Florencia Judith Duartez7Lumila Curletto8Instituto de Desarrollo Agroindustrial y de la Salud (IDAS-CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, Universidad Nacional de Rio Cuarto, Rio Cuarto, ArgentinaInstituto de Desarrollo Agroindustrial y de la Salud (IDAS-CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, Universidad Nacional de Rio Cuarto, Rio Cuarto, ArgentinaInstituto de Investigación Médica Mercedes y Martín Ferreyra (INIMEC), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Córdoba, Córdoba, ArgentinaInstituto de Ciencias de la Tierra, Biodiversidad y Ambiente (ICBIA – UNRC-CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, Universidad Nacional de Rio Cuarto, Rio Cuarto, ArgentinaInstituto de Investigación Médica Mercedes y Martín Ferreyra (INIMEC), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Córdoba, Córdoba, ArgentinaDepartamento de Patología Animal, Facultad de Agronomía y Veterinaria, Universidad Nacional de Rio Cuarto, Rio Cuarto, ArgentinaDepartamento de Patología Animal, Facultad de Agronomía y Veterinaria, Universidad Nacional de Rio Cuarto, Rio Cuarto, ArgentinaInstituto de Desarrollo Agroindustrial y de la Salud (IDAS-CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, Universidad Nacional de Rio Cuarto, Rio Cuarto, ArgentinaDepartamento de Patología Animal, Facultad de Agronomía y Veterinaria, Universidad Nacional de Rio Cuarto, Rio Cuarto, ArgentinaIntroductionCryptosporidium spp. is an intestinal protozoan causing cryptosporidiosis, a diarrheal disease affecting humans and animals, with zoonotic potential. In immunocompromised individuals, infections can be severe or fatal. It is a major waterborne parasite and a leading cause of neonatal diarrhea in calves. This study systematically reviews Cryptosporidium spp. research in Argentina during the 21st century, highlighting its epidemiological significance and research gaps.MethodsA systematic review following PRISMA guidelines was conducted using LILACS, PubMed, Scopus, and SciELO Argentina. Eligible studies (2001–2024) included human (community and hospital-based), animal (domestic, wild, and captive), and environmental (water, soil and vegetable) surveys. The review analyzed epidemiology, diagnosis, treatment, genetic diversity, distribution, and risk factors.ResultsOf 277 articles reviewed, 66 met eligibility criteria. Cryptosporidium spp. was detected in 17 of Argentina’s 23 provinces, mainly in the Pampean region. Five species were identified (C. hominis, C. parvum, C. suis, C. scrofarum, and C. varanii), though genetic diversity studies remain limited. Human cryptosporidiosis primarily affects immunocompromised individuals (HIV/AIDS, transplant recipients, hematologic cancer patients). The parasite was found in feces, duodenal biopsies, blood, sputum, and cerebrospinal fluid, with complications such as cholangiopathy and pulmonary cryptosporidiosis. Infections with C. hominis and C. parvum (including co-infections) were observed, with multiple subtypes documented. In animals, C. parvum was prevalent in Pampean calves, while C. suis and C. scrofarum were found in domestic pigs. Wildlife, including non-human primates and coypu, also tested positive. Cryptosporidium was detected in recreational and drinking water samples. No Cryptosporidium spp. oocysts were detected in soil. Risk factors included socio-economic conditions and animal management practices.ConclusionCryptosporidium spp. is widely distributed in Argentina, yet eco-epidemiological transmission factors remain poorly understood, hindering control strategies. Limited research on genetic diversity and distribution highlights the need for further studies, particularly in vulnerable populations and areas of close human-animal interaction, such as productive systems. The presence of Cryptosporidium spp. in water underscores the importance of improving public health policies and water treatment standards. From a One Health perspective, these findings emphasize the need for enhanced epidemiological surveillance and research to strengthen prevention and control in Argentina.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1592564/fullCryptosporidiumprevalencezoonotic potentialdiagnostic techniquesrisk factorsone-health
spellingShingle Maria Romina Rivero
Claudina Vissio
Constanza Feliziani
Carlos De Angelo
Maria Carolina Touz
Karina Tiranti
Joaquín Andrés Lombardelli
Florencia Judith Duartez
Lumila Curletto
Cryptosporidium spp. in Argentina: epidemiology and research advances in human, animal, and environmental settings during the 21st century
Frontiers in Microbiology
Cryptosporidium
prevalence
zoonotic potential
diagnostic techniques
risk factors
one-health
title Cryptosporidium spp. in Argentina: epidemiology and research advances in human, animal, and environmental settings during the 21st century
title_full Cryptosporidium spp. in Argentina: epidemiology and research advances in human, animal, and environmental settings during the 21st century
title_fullStr Cryptosporidium spp. in Argentina: epidemiology and research advances in human, animal, and environmental settings during the 21st century
title_full_unstemmed Cryptosporidium spp. in Argentina: epidemiology and research advances in human, animal, and environmental settings during the 21st century
title_short Cryptosporidium spp. in Argentina: epidemiology and research advances in human, animal, and environmental settings during the 21st century
title_sort cryptosporidium spp in argentina epidemiology and research advances in human animal and environmental settings during the 21st century
topic Cryptosporidium
prevalence
zoonotic potential
diagnostic techniques
risk factors
one-health
url https://www.frontiersin.org/articles/10.3389/fmicb.2025.1592564/full
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