Uric Acid, Colchicine and Chronic Inflammatory Diseases: A Cardiovascular Perspective
Based on the notion that inflammation plays a pivotal role in the development and progression of cardiovascular diseases (CV) and that hyperuricaemia is an independent CV risk factor, chronic inflammatory diseases such as gout and rheumatoid arthritis are an interesting case study. Both conditions a...
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MDPI AG
2025-06-01
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| Online Access: | https://www.mdpi.com/2218-1989/15/7/424 |
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| author | Alessia Alunno Francesco Carubbi Claudio Ferri |
| author_facet | Alessia Alunno Francesco Carubbi Claudio Ferri |
| author_sort | Alessia Alunno |
| collection | DOAJ |
| description | Based on the notion that inflammation plays a pivotal role in the development and progression of cardiovascular diseases (CV) and that hyperuricaemia is an independent CV risk factor, chronic inflammatory diseases such as gout and rheumatoid arthritis are an interesting case study. Both conditions are burdened by an excess CV risk; they are themselves an independent CV risk factor, and in the case of gout, hyperuricaemia is a hallmark of the disease. Colchicine, a drug historically used for the management of gout, has recently been repurposed for secondary CV prevention in individuals at high CV risk. The purpose of this review article is to discuss evidence on CV diseases and CV prevention in rheumatoid arthritis, gout, and other chronic inflammatory/systemic autoimmune diseases with a focus on inflammation and hyperuricaemia. |
| format | Article |
| id | doaj-art-a88373cdc7fb4f838a248f13f9cf8300 |
| institution | DOAJ |
| issn | 2218-1989 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj-art-a88373cdc7fb4f838a248f13f9cf83002025-08-20T03:07:55ZengMDPI AGMetabolites2218-19892025-06-0115742410.3390/metabo15070424Uric Acid, Colchicine and Chronic Inflammatory Diseases: A Cardiovascular PerspectiveAlessia Alunno0Francesco Carubbi1Claudio Ferri2Department of Clinical Medicine, Life, Health and Environmental Sciences, Internal Medicine and Nephrology Division, ASL1 Avezzano-Sulmona-L’Aquila, San Salvatore Hospital, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Clinical Medicine, Life, Health and Environmental Sciences, Internal Medicine and Nephrology Division, ASL1 Avezzano-Sulmona-L’Aquila, San Salvatore Hospital, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Clinical Medicine, Life, Health and Environmental Sciences, Internal Medicine and Nephrology Division, ASL1 Avezzano-Sulmona-L’Aquila, San Salvatore Hospital, University of L’Aquila, 67100 L’Aquila, ItalyBased on the notion that inflammation plays a pivotal role in the development and progression of cardiovascular diseases (CV) and that hyperuricaemia is an independent CV risk factor, chronic inflammatory diseases such as gout and rheumatoid arthritis are an interesting case study. Both conditions are burdened by an excess CV risk; they are themselves an independent CV risk factor, and in the case of gout, hyperuricaemia is a hallmark of the disease. Colchicine, a drug historically used for the management of gout, has recently been repurposed for secondary CV prevention in individuals at high CV risk. The purpose of this review article is to discuss evidence on CV diseases and CV prevention in rheumatoid arthritis, gout, and other chronic inflammatory/systemic autoimmune diseases with a focus on inflammation and hyperuricaemia.https://www.mdpi.com/2218-1989/15/7/424uric acidcolchicinegoutrheumatoid arthritispsoriatic arthritis |
| spellingShingle | Alessia Alunno Francesco Carubbi Claudio Ferri Uric Acid, Colchicine and Chronic Inflammatory Diseases: A Cardiovascular Perspective Metabolites uric acid colchicine gout rheumatoid arthritis psoriatic arthritis |
| title | Uric Acid, Colchicine and Chronic Inflammatory Diseases: A Cardiovascular Perspective |
| title_full | Uric Acid, Colchicine and Chronic Inflammatory Diseases: A Cardiovascular Perspective |
| title_fullStr | Uric Acid, Colchicine and Chronic Inflammatory Diseases: A Cardiovascular Perspective |
| title_full_unstemmed | Uric Acid, Colchicine and Chronic Inflammatory Diseases: A Cardiovascular Perspective |
| title_short | Uric Acid, Colchicine and Chronic Inflammatory Diseases: A Cardiovascular Perspective |
| title_sort | uric acid colchicine and chronic inflammatory diseases a cardiovascular perspective |
| topic | uric acid colchicine gout rheumatoid arthritis psoriatic arthritis |
| url | https://www.mdpi.com/2218-1989/15/7/424 |
| work_keys_str_mv | AT alessiaalunno uricacidcolchicineandchronicinflammatorydiseasesacardiovascularperspective AT francescocarubbi uricacidcolchicineandchronicinflammatorydiseasesacardiovascularperspective AT claudioferri uricacidcolchicineandchronicinflammatorydiseasesacardiovascularperspective |