Morphologic features of crystalline lens in cataract patients with different lens sclerosis and axial length
Abstract Introduction To investigate morphological features of crystalline lens in cataract patients and examine the association between lens nucleus sclerosis, axial length (AL), and lens morphology. Methods This retrospective study consecutive included 285 left cataract eyes at Peking University T...
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BMC
2025-07-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-025-04148-y |
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| author | Rui Qin Jing Ding Yiyun Liu Qianqian Lan Tong Sun Linbo Bian Dehai Liu Xiaoyu Wang Jiawei Chen Zhengze Sun Hong Qi |
| author_facet | Rui Qin Jing Ding Yiyun Liu Qianqian Lan Tong Sun Linbo Bian Dehai Liu Xiaoyu Wang Jiawei Chen Zhengze Sun Hong Qi |
| author_sort | Rui Qin |
| collection | DOAJ |
| description | Abstract Introduction To investigate morphological features of crystalline lens in cataract patients and examine the association between lens nucleus sclerosis, axial length (AL), and lens morphology. Methods This retrospective study consecutive included 285 left cataract eyes at Peking University Third Hospital between July 2022 and June 2023. Lens parameters were measured using CASIA2 and IOL Master 700. Patients were sub-grouped by Emery-Little classification and AL. Statistical and regression analyses were performed. Results Severe nuclear sclerosis (Emery-Little grade IV) exhibited smaller back curvature radii (BCR; P = 0.008), lens diameter (P = 0.005), and greater lens decentration (P = 0.012). Long AL eyes (≥ 25.5 mm) showed higher lens decentration (P = 0.026) and lower lens tilt (P < 0.001). BCR strongly correlated with lens diameter (r = 0.904, P < 0.001). Regression identified lens diameter as the primary predictor of BCR (β = 0.758). Compared with the decentration of the lens (R² = 0.045), tilt is easier to predict (R² = 0.125). Conclusion The degree of lens nucleus sclerosis and axial length may affect the morphologic features of the lens. It may be considered that how the lens morphology with excessive nucleus sclerosis or abnormal axial length impact the efficacy and safety of cataract surgery. |
| format | Article |
| id | doaj-art-a87df7c1a74444298bd69e1ef3d5bf17 |
| institution | Kabale University |
| issn | 1471-2415 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj-art-a87df7c1a74444298bd69e1ef3d5bf172025-08-20T03:37:20ZengBMCBMC Ophthalmology1471-24152025-07-0125111110.1186/s12886-025-04148-yMorphologic features of crystalline lens in cataract patients with different lens sclerosis and axial lengthRui Qin0Jing Ding1Yiyun Liu2Qianqian Lan3Tong Sun4Linbo Bian5Dehai Liu6Xiaoyu Wang7Jiawei Chen8Zhengze Sun9Hong Qi10Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third HospitalDepartment of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third HospitalDepartment of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third HospitalDepartment of Ophthalmology, the People’s Hospital of Guangxi Zhuang Autonomous RegionDepartment of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third HospitalDepartment of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third HospitalDepartment of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third HospitalDepartment of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third HospitalDepartment of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third HospitalDepartment of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third HospitalDepartment of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third HospitalAbstract Introduction To investigate morphological features of crystalline lens in cataract patients and examine the association between lens nucleus sclerosis, axial length (AL), and lens morphology. Methods This retrospective study consecutive included 285 left cataract eyes at Peking University Third Hospital between July 2022 and June 2023. Lens parameters were measured using CASIA2 and IOL Master 700. Patients were sub-grouped by Emery-Little classification and AL. Statistical and regression analyses were performed. Results Severe nuclear sclerosis (Emery-Little grade IV) exhibited smaller back curvature radii (BCR; P = 0.008), lens diameter (P = 0.005), and greater lens decentration (P = 0.012). Long AL eyes (≥ 25.5 mm) showed higher lens decentration (P = 0.026) and lower lens tilt (P < 0.001). BCR strongly correlated with lens diameter (r = 0.904, P < 0.001). Regression identified lens diameter as the primary predictor of BCR (β = 0.758). Compared with the decentration of the lens (R² = 0.045), tilt is easier to predict (R² = 0.125). Conclusion The degree of lens nucleus sclerosis and axial length may affect the morphologic features of the lens. It may be considered that how the lens morphology with excessive nucleus sclerosis or abnormal axial length impact the efficacy and safety of cataract surgery.https://doi.org/10.1186/s12886-025-04148-yCataractLens morphologyNuclear sclerosisAxial length |
| spellingShingle | Rui Qin Jing Ding Yiyun Liu Qianqian Lan Tong Sun Linbo Bian Dehai Liu Xiaoyu Wang Jiawei Chen Zhengze Sun Hong Qi Morphologic features of crystalline lens in cataract patients with different lens sclerosis and axial length BMC Ophthalmology Cataract Lens morphology Nuclear sclerosis Axial length |
| title | Morphologic features of crystalline lens in cataract patients with different lens sclerosis and axial length |
| title_full | Morphologic features of crystalline lens in cataract patients with different lens sclerosis and axial length |
| title_fullStr | Morphologic features of crystalline lens in cataract patients with different lens sclerosis and axial length |
| title_full_unstemmed | Morphologic features of crystalline lens in cataract patients with different lens sclerosis and axial length |
| title_short | Morphologic features of crystalline lens in cataract patients with different lens sclerosis and axial length |
| title_sort | morphologic features of crystalline lens in cataract patients with different lens sclerosis and axial length |
| topic | Cataract Lens morphology Nuclear sclerosis Axial length |
| url | https://doi.org/10.1186/s12886-025-04148-y |
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