Clinical efficacy of low‐dose Perampanel correlates with neurophysiological changes in familial adult myoclonus epilepsy 2

Clinical efficacy of low‐dose Perampanel correlates with neurophysiological changes in familial adult myoclonus epilepsy 2

Abstract Familial adult myoclonus epilepsy (FAME) management relies on antiseizure medications (ASMs), which inadequately address myoclonus and cortical tremor. This study evaluates Perampanel (PER), an AMPA‐receptor antagonist, for treating FAME symptoms. Fifteen FAME2 patients participated in an o...

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Main Authors: Antonietta Coppola, Claudia Cuccurullo, Gianmaria Senerchia, Marica Rubino, Liana Veneziano, Francesco Brancati, Luigi Baratto, Valentina Virginia Iuzzolino, Leonilda Bilo, Pasquale Striano, Raffaele Dubbioso
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Epilepsia Open
Subjects:
myoclonus
Perampanel
somatosensory evoked potentials
transcranial magnetic stimulation
Online Access:https://doi.org/10.1002/epi4.13100
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