In Vitro Inhibitory Activity of Corilagin and Punicalagin Against <i>Toxoplasma gondii</i> and Their Mechanism(s) of Action

<b>Background/Objectives:</b> Toxoplasmosis is a zoonotic disease caused by <i>Toxoplasma gondii</i>. The parasite infection in humans continues to rise due to an increasing seroprevalence rate in domestic and wild warm-blooded animals that serve as a major reservoir of the p...

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Main Authors: Nicole T. Green-Ross, Homa Nath Sharma, Audrey Napier, Boakai K. Robertson, Robert L. Green, Daniel A. Abugri
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Antibiotics
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Online Access:https://www.mdpi.com/2079-6382/14/4/336
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author Nicole T. Green-Ross
Homa Nath Sharma
Audrey Napier
Boakai K. Robertson
Robert L. Green
Daniel A. Abugri
author_facet Nicole T. Green-Ross
Homa Nath Sharma
Audrey Napier
Boakai K. Robertson
Robert L. Green
Daniel A. Abugri
author_sort Nicole T. Green-Ross
collection DOAJ
description <b>Background/Objectives:</b> Toxoplasmosis is a zoonotic disease caused by <i>Toxoplasma gondii</i>. The parasite infection in humans continues to rise due to an increasing seroprevalence rate in domestic and wild warm-blooded animals that serve as a major reservoir of the parasite. There are fewer drugs available for the treatment of toxoplasmosis. However, these drugs are limited in efficacy against tachyzoites and bradyzoites. Also, there are clinical side effects and geographical barriers to their use, especially in immunocompromised patients, children, and pregnant women. Tannins, a class of natural products, are known to have antimicrobial properties. However, little is known about the effects of Corilagin (CG) and Punicalagin (PU), which are classified as tannins, on <i>T. gondii</i> growth and their possible mechanism of action in vitro. We hypothesize that CG and PU could inhibit <i>T. gondii</i> growth in vitro and cause mitochondria membrane disruption via oxidative stress. <b>Methods:</b> Here, we investigated the anti-<i>T. gondii</i> activity of the two named tannins using a fluorescent-based reporter assay. <b>Results:</b> The 50% effective concentrations (EC<sub>50s</sub>) values for CG and PU that inhibited <i>T. gondii</i> parasites growth in vitro were determined to be 3.09 and 19.33 µM, respectively. Pyrimethamine (PY) was used as a standard control which gave an EC<sub>50</sub> value of 0.25 µM. Interestingly, CG and PU were observed to cause high reactive oxygen species (ROS) and mitochondrial superoxide (MitoSOX) production in tachyzoites. This resulted in a strong mitochondria membrane potential (MMP) disruption in <i>T. gondii</i> tachyzoites. <b>Conclusions:</b> Therefore, the possible mechanism(s) of action of CG and PU against <i>T. gondii</i> is associated with the disruption of the mitochondria redox biology. Thus, the high ROS and MitoSOX produced as a result of these compounds created high oxidative stress, leading to mitochondrial dysfunction.
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spelling doaj-art-a873ba20baf749c6a5f142fb4a67e3d52025-08-20T02:28:40ZengMDPI AGAntibiotics2079-63822025-03-0114433610.3390/antibiotics14040336In Vitro Inhibitory Activity of Corilagin and Punicalagin Against <i>Toxoplasma gondii</i> and Their Mechanism(s) of ActionNicole T. Green-Ross0Homa Nath Sharma1Audrey Napier2Boakai K. Robertson3Robert L. Green4Daniel A. Abugri5Department of Biological Sciences, Alabama State University, Montgomery, AL 36104, USADepartment of Biological Sciences, Alabama State University, Montgomery, AL 36104, USADepartment of Biological Sciences, Alabama State University, Montgomery, AL 36104, USADepartment of Biological Sciences, Alabama State University, Montgomery, AL 36104, USADepartment of Physical Sciences, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL 36104, USADepartment of Biological Sciences, Alabama State University, Montgomery, AL 36104, USA<b>Background/Objectives:</b> Toxoplasmosis is a zoonotic disease caused by <i>Toxoplasma gondii</i>. The parasite infection in humans continues to rise due to an increasing seroprevalence rate in domestic and wild warm-blooded animals that serve as a major reservoir of the parasite. There are fewer drugs available for the treatment of toxoplasmosis. However, these drugs are limited in efficacy against tachyzoites and bradyzoites. Also, there are clinical side effects and geographical barriers to their use, especially in immunocompromised patients, children, and pregnant women. Tannins, a class of natural products, are known to have antimicrobial properties. However, little is known about the effects of Corilagin (CG) and Punicalagin (PU), which are classified as tannins, on <i>T. gondii</i> growth and their possible mechanism of action in vitro. We hypothesize that CG and PU could inhibit <i>T. gondii</i> growth in vitro and cause mitochondria membrane disruption via oxidative stress. <b>Methods:</b> Here, we investigated the anti-<i>T. gondii</i> activity of the two named tannins using a fluorescent-based reporter assay. <b>Results:</b> The 50% effective concentrations (EC<sub>50s</sub>) values for CG and PU that inhibited <i>T. gondii</i> parasites growth in vitro were determined to be 3.09 and 19.33 µM, respectively. Pyrimethamine (PY) was used as a standard control which gave an EC<sub>50</sub> value of 0.25 µM. Interestingly, CG and PU were observed to cause high reactive oxygen species (ROS) and mitochondrial superoxide (MitoSOX) production in tachyzoites. This resulted in a strong mitochondria membrane potential (MMP) disruption in <i>T. gondii</i> tachyzoites. <b>Conclusions:</b> Therefore, the possible mechanism(s) of action of CG and PU against <i>T. gondii</i> is associated with the disruption of the mitochondria redox biology. Thus, the high ROS and MitoSOX produced as a result of these compounds created high oxidative stress, leading to mitochondrial dysfunction.https://www.mdpi.com/2079-6382/14/4/336corilaginpunicalaginpyrimethamineinhibit<i>T. gondii</i>
spellingShingle Nicole T. Green-Ross
Homa Nath Sharma
Audrey Napier
Boakai K. Robertson
Robert L. Green
Daniel A. Abugri
In Vitro Inhibitory Activity of Corilagin and Punicalagin Against <i>Toxoplasma gondii</i> and Their Mechanism(s) of Action
Antibiotics
corilagin
punicalagin
pyrimethamine
inhibit
<i>T. gondii</i>
title In Vitro Inhibitory Activity of Corilagin and Punicalagin Against <i>Toxoplasma gondii</i> and Their Mechanism(s) of Action
title_full In Vitro Inhibitory Activity of Corilagin and Punicalagin Against <i>Toxoplasma gondii</i> and Their Mechanism(s) of Action
title_fullStr In Vitro Inhibitory Activity of Corilagin and Punicalagin Against <i>Toxoplasma gondii</i> and Their Mechanism(s) of Action
title_full_unstemmed In Vitro Inhibitory Activity of Corilagin and Punicalagin Against <i>Toxoplasma gondii</i> and Their Mechanism(s) of Action
title_short In Vitro Inhibitory Activity of Corilagin and Punicalagin Against <i>Toxoplasma gondii</i> and Their Mechanism(s) of Action
title_sort in vitro inhibitory activity of corilagin and punicalagin against i toxoplasma gondii i and their mechanism s of action
topic corilagin
punicalagin
pyrimethamine
inhibit
<i>T. gondii</i>
url https://www.mdpi.com/2079-6382/14/4/336
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