Morphological and Immunohistochemical Support for the Origin of the Carcinoid Component in Strumal Carcinoids: A Case Report and Literature Review
Strumal carcinoid tumors of the ovary are rare neoplasms composed of an intimate mixture of thyroid and carcinoid tissues. Although various theories regarding their histogenesis have been proposed, evidence confirming the origin of the carcinoid component has been lacking. We report a case of a 40-y...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/15/10/1249 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850126442322460672 |
|---|---|
| author | Yu Liu Asra Feroze Liz Yang Ridin Balakrishnan |
| author_facet | Yu Liu Asra Feroze Liz Yang Ridin Balakrishnan |
| author_sort | Yu Liu |
| collection | DOAJ |
| description | Strumal carcinoid tumors of the ovary are rare neoplasms composed of an intimate mixture of thyroid and carcinoid tissues. Although various theories regarding their histogenesis have been proposed, evidence confirming the origin of the carcinoid component has been lacking. We report a case of a 40-year-old female with an ovarian strumal carcinoid arising in the background of a mature cystic teratoma. Morphological and immunohistochemical findings support the hypothesis that the carcinoid component originates from the thyroid follicular epithelium, undergoing neuroendocrine differentiation. A single-cell growth pattern was also identified, expanding the known histological spectrum of strumal carcinoids. Our case provides additional immunohistochemical support for the histogenetic origin of strumal carcinoids, offering new insights into their pathogenesis. Recognizing these distinct patterns of staining and unusual morphology is critical for accurate diagnosis and differentiation from metastatic disease. |
| format | Article |
| id | doaj-art-a872276de1ce4f6aa6233392d5770528 |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-a872276de1ce4f6aa6233392d57705282025-08-20T02:33:55ZengMDPI AGDiagnostics2075-44182025-05-011510124910.3390/diagnostics15101249Morphological and Immunohistochemical Support for the Origin of the Carcinoid Component in Strumal Carcinoids: A Case Report and Literature ReviewYu Liu0Asra Feroze1Liz Yang2Ridin Balakrishnan3Department of Pathology, LSUHSC School of Medicine, New Orleans, LA 70112, USADepartment of Pathology, LSUHSC School of Medicine, New Orleans, LA 70112, USADepartment of Pathology, LSUHSC School of Medicine, New Orleans, LA 70112, USADepartment of Pathology, LSUHSC School of Medicine, New Orleans, LA 70112, USAStrumal carcinoid tumors of the ovary are rare neoplasms composed of an intimate mixture of thyroid and carcinoid tissues. Although various theories regarding their histogenesis have been proposed, evidence confirming the origin of the carcinoid component has been lacking. We report a case of a 40-year-old female with an ovarian strumal carcinoid arising in the background of a mature cystic teratoma. Morphological and immunohistochemical findings support the hypothesis that the carcinoid component originates from the thyroid follicular epithelium, undergoing neuroendocrine differentiation. A single-cell growth pattern was also identified, expanding the known histological spectrum of strumal carcinoids. Our case provides additional immunohistochemical support for the histogenetic origin of strumal carcinoids, offering new insights into their pathogenesis. Recognizing these distinct patterns of staining and unusual morphology is critical for accurate diagnosis and differentiation from metastatic disease.https://www.mdpi.com/2075-4418/15/10/1249ovarystrumal carcinoidstrumal ovariithyroidsingle cell patternTTF-1 |
| spellingShingle | Yu Liu Asra Feroze Liz Yang Ridin Balakrishnan Morphological and Immunohistochemical Support for the Origin of the Carcinoid Component in Strumal Carcinoids: A Case Report and Literature Review Diagnostics ovary strumal carcinoid strumal ovarii thyroid single cell pattern TTF-1 |
| title | Morphological and Immunohistochemical Support for the Origin of the Carcinoid Component in Strumal Carcinoids: A Case Report and Literature Review |
| title_full | Morphological and Immunohistochemical Support for the Origin of the Carcinoid Component in Strumal Carcinoids: A Case Report and Literature Review |
| title_fullStr | Morphological and Immunohistochemical Support for the Origin of the Carcinoid Component in Strumal Carcinoids: A Case Report and Literature Review |
| title_full_unstemmed | Morphological and Immunohistochemical Support for the Origin of the Carcinoid Component in Strumal Carcinoids: A Case Report and Literature Review |
| title_short | Morphological and Immunohistochemical Support for the Origin of the Carcinoid Component in Strumal Carcinoids: A Case Report and Literature Review |
| title_sort | morphological and immunohistochemical support for the origin of the carcinoid component in strumal carcinoids a case report and literature review |
| topic | ovary strumal carcinoid strumal ovarii thyroid single cell pattern TTF-1 |
| url | https://www.mdpi.com/2075-4418/15/10/1249 |
| work_keys_str_mv | AT yuliu morphologicalandimmunohistochemicalsupportfortheoriginofthecarcinoidcomponentinstrumalcarcinoidsacasereportandliteraturereview AT asraferoze morphologicalandimmunohistochemicalsupportfortheoriginofthecarcinoidcomponentinstrumalcarcinoidsacasereportandliteraturereview AT lizyang morphologicalandimmunohistochemicalsupportfortheoriginofthecarcinoidcomponentinstrumalcarcinoidsacasereportandliteraturereview AT ridinbalakrishnan morphologicalandimmunohistochemicalsupportfortheoriginofthecarcinoidcomponentinstrumalcarcinoidsacasereportandliteraturereview |