Acute Exposure to Microcystin-Producing Cyanobacterium Microcystis aeruginosa Alters Adult Zebrafish (Danio rerio) Swimming Performance Parameters
Microcystins (MCs) are toxins produced by cyanobacteria (blue-green algae), primarily Microcystis aeruginosa, forming water blooms worldwide. When an organism is exposed to environmental perturbations, alterations in normal behavioral patterns occur. Behavioral repertoire represents the consequence...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2011/280304 |
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| author | Luiza Wilges Kist Angelo Luis Piato João Gabriel Santos da Rosa Gessi Koakoski Leonardo José Gil Barcellos João Sarkis Yunes Carla Denise Bonan Maurício Reis Bogo |
| author_facet | Luiza Wilges Kist Angelo Luis Piato João Gabriel Santos da Rosa Gessi Koakoski Leonardo José Gil Barcellos João Sarkis Yunes Carla Denise Bonan Maurício Reis Bogo |
| author_sort | Luiza Wilges Kist |
| collection | DOAJ |
| description | Microcystins (MCs) are toxins produced by cyanobacteria (blue-green algae), primarily Microcystis aeruginosa, forming water blooms worldwide. When an organism is exposed to environmental perturbations, alterations in normal behavioral patterns occur. Behavioral repertoire represents the consequence of a diversity of physiological and biochemical alterations. In this study, we assessed behavioral patterns and whole-body cortisol levels of adult zebrafish (Danio rerio) exposed to cell culture of the microcystin-producing cyanobacterium M. aeruginosa (MC-LR, strain RST9501). MC-LR exposure (100 μg/L) decreased by 63% the distance traveled and increased threefold the immobility time when compared to the control group. Interestingly, no significant alterations in the number of line crossings were found at the same MC-LR concentration and time of exposure. When animals were exposed to 50 and 100 μg/L, MC-LR promoted a significant increase (around 93%) in the time spent in the bottom portion of the tank, suggesting an anxiogenic effect. The results also showed that none of the MC-LR concentrations tested promoted significant alterations in absolute turn angle, path efficiency, social behavior, or whole-body cortisol level. These findings indicate that behavior is susceptible to MC-LR exposure and provide evidence for a better understanding of the ecological consequences of toxic algal blooms. |
| format | Article |
| id | doaj-art-a86fbf6cc92e47c8a54a32f2868ebc1d |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-a86fbf6cc92e47c8a54a32f2868ebc1d2025-02-03T00:59:38ZengWileyJournal of Toxicology1687-81911687-82052011-01-01201110.1155/2011/280304280304Acute Exposure to Microcystin-Producing Cyanobacterium Microcystis aeruginosa Alters Adult Zebrafish (Danio rerio) Swimming Performance ParametersLuiza Wilges Kist0Angelo Luis Piato1João Gabriel Santos da Rosa2Gessi Koakoski3Leonardo José Gil Barcellos4João Sarkis Yunes5Carla Denise Bonan6Maurício Reis Bogo7Laboratório de Biologia Genômica e Molecular, Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul, Avenida Ipiranga 6681, 90619-900 Porto Alegre, RS, BrazilInstituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital de Clínicas, Rua Ramiro Barcelos 2350, 90035-003 Porto Alegre, RS, BrazilPrograma de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Avenida Roraima 1000, 97105-900 Santa Maria, RS, BrazilPrograma de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Avenida Roraima 1000, 97105-900 Santa Maria, RS, BrazilCurso de Medicina Veterinária, Universidade de Passo Fundo, Campus Universitário, Caixa Postal 611, 99001-970 Passo Fundo, RS, BrazilUnidade de Pesquisas em Cianobactérias, Prédio da Hidroquímica, Instituto de Oceanografia, Campus Carreiros da FURG, Caixa Postal 474, Rio Grande, RS, BrazilInstituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital de Clínicas, Rua Ramiro Barcelos 2350, 90035-003 Porto Alegre, RS, BrazilLaboratório de Biologia Genômica e Molecular, Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul, Avenida Ipiranga 6681, 90619-900 Porto Alegre, RS, BrazilMicrocystins (MCs) are toxins produced by cyanobacteria (blue-green algae), primarily Microcystis aeruginosa, forming water blooms worldwide. When an organism is exposed to environmental perturbations, alterations in normal behavioral patterns occur. Behavioral repertoire represents the consequence of a diversity of physiological and biochemical alterations. In this study, we assessed behavioral patterns and whole-body cortisol levels of adult zebrafish (Danio rerio) exposed to cell culture of the microcystin-producing cyanobacterium M. aeruginosa (MC-LR, strain RST9501). MC-LR exposure (100 μg/L) decreased by 63% the distance traveled and increased threefold the immobility time when compared to the control group. Interestingly, no significant alterations in the number of line crossings were found at the same MC-LR concentration and time of exposure. When animals were exposed to 50 and 100 μg/L, MC-LR promoted a significant increase (around 93%) in the time spent in the bottom portion of the tank, suggesting an anxiogenic effect. The results also showed that none of the MC-LR concentrations tested promoted significant alterations in absolute turn angle, path efficiency, social behavior, or whole-body cortisol level. These findings indicate that behavior is susceptible to MC-LR exposure and provide evidence for a better understanding of the ecological consequences of toxic algal blooms.http://dx.doi.org/10.1155/2011/280304 |
| spellingShingle | Luiza Wilges Kist Angelo Luis Piato João Gabriel Santos da Rosa Gessi Koakoski Leonardo José Gil Barcellos João Sarkis Yunes Carla Denise Bonan Maurício Reis Bogo Acute Exposure to Microcystin-Producing Cyanobacterium Microcystis aeruginosa Alters Adult Zebrafish (Danio rerio) Swimming Performance Parameters Journal of Toxicology |
| title | Acute Exposure to Microcystin-Producing Cyanobacterium Microcystis aeruginosa Alters Adult Zebrafish (Danio rerio) Swimming Performance Parameters |
| title_full | Acute Exposure to Microcystin-Producing Cyanobacterium Microcystis aeruginosa Alters Adult Zebrafish (Danio rerio) Swimming Performance Parameters |
| title_fullStr | Acute Exposure to Microcystin-Producing Cyanobacterium Microcystis aeruginosa Alters Adult Zebrafish (Danio rerio) Swimming Performance Parameters |
| title_full_unstemmed | Acute Exposure to Microcystin-Producing Cyanobacterium Microcystis aeruginosa Alters Adult Zebrafish (Danio rerio) Swimming Performance Parameters |
| title_short | Acute Exposure to Microcystin-Producing Cyanobacterium Microcystis aeruginosa Alters Adult Zebrafish (Danio rerio) Swimming Performance Parameters |
| title_sort | acute exposure to microcystin producing cyanobacterium microcystis aeruginosa alters adult zebrafish danio rerio swimming performance parameters |
| url | http://dx.doi.org/10.1155/2011/280304 |
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