Epithelial mitochondrial fission-mediated PANoptosis is crucial for ulcerative colitis and its inhibition by saquinavir through Drp1

Epithelial mitochondrial fission-mediated PANoptosis is crucial for ulcerative colitis and its inhibition by saquinavir through Drp1

Ulcerative colitis (UC) is characterized by increased cell death in intestinal epithelial cell (IEC), which compromises gut barrier function and activates inflammation. Aberrant mitochondrial dynamics have been implicated in various forms of cell death, but it is currently unclear if they play a rol...

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Bibliographic Details
Main Authors: Zhiming Ye, Mingxia Deng, Yang Yang, Yuanming Song, Liangkun Weng, Wanchen Qi, Ping Ding, Yihang Huang, Can Yu, Yan Wang, Yixing Wu, Yan Zhang, Shaoying Yuan, Wenkai Nie, Luyong Zhang, Cheng Zeng
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Pharmacological Research
Subjects:
Ulcerative colitis
Mitochondrial fission
Drp1
PANoptosis
ZBP1
Saquinavir
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824004833
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