Disrupted Regional Spontaneous Neural Activity in Mild Cognitive Impairment Patients with Depressive Symptoms: A Resting-State fMRI Study
Depressive symptoms are common in individuals with mild cognitive impairment (MCI) who have an increased risk of dementia. It is currently unclear whether the pattern of spontaneous brain activity in patients with MCI differs between subjects with and without depressive symptoms. The current study s...
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| Language: | English |
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Wiley
2019-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2019/2981764 |
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| author | Xiaozheng Liu Yunhai Tu Yirou Zang Aiqin Wu Zhongwei Guo Jiawei He |
| author_facet | Xiaozheng Liu Yunhai Tu Yirou Zang Aiqin Wu Zhongwei Guo Jiawei He |
| author_sort | Xiaozheng Liu |
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| description | Depressive symptoms are common in individuals with mild cognitive impairment (MCI) who have an increased risk of dementia. It is currently unclear whether the pattern of spontaneous brain activity in patients with MCI differs between subjects with and without depressive symptoms. The current study sought to investigate the features of spontaneous brain activity in MCI patients with depressive symptoms (D-MCI) using coherence regional homogeneity (CReHo) analysis with resting-state functional magnetic resonance imaging (rsfMRI). We obtained rsfMRI data in 16 MCI patients with depressive symptoms and 18 nondepressed MCI patients (nD-MCI) using a 3 T scanner. Statistical analyses were performed to determine the regions in which ReHo differed between the two groups in specific frequency bands, slow-4 (0.027–0.073 Hz) and slow-5 (0.010–0.027 Hz), and typical bands (0.01–0.08 Hz). Correlation analyses were performed between the CReHo index of these regions and clinical variables to evaluate the relationship between CReHo and pathophysiological measures in the two groups. Our results showed that D-MCI patients exhibited significantly higher CReHo in the left Heschl’s gyrus and left thalamus and lower CReHo in the left postcentral gyrus in the typical frequency band. In the slow-4 frequency band, D-MCI patients showed significantly higher CReHo in the left Heschl’s gyrus and left thalamus. In the slow-5 frequency band, D-MCI patients exhibited significantly lower CReHo in the superior medial prefrontal gyrus. In addition, the results revealed that CReHo values in the left thalamus were positively correlated with Hamilton Depression Rating Scale (HAMD) scores in D-MCI patients. These results suggest that the sensorimotor network may be one of the main pathophysiological factors in D-MCI. |
| format | Article |
| id | doaj-art-a86a45b2e4dd4a2bbfc74b5a296f5a06 |
| institution | Kabale University |
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| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
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| series | Neural Plasticity |
| spelling | doaj-art-a86a45b2e4dd4a2bbfc74b5a296f5a062025-02-03T06:07:27ZengWileyNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/29817642981764Disrupted Regional Spontaneous Neural Activity in Mild Cognitive Impairment Patients with Depressive Symptoms: A Resting-State fMRI StudyXiaozheng Liu0Yunhai Tu1Yirou Zang2Aiqin Wu3Zhongwei Guo4Jiawei He5China-USA Neuroimaging Research Institute, Department of Radiology of the Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, ChinaThe Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, ChinaChina-USA Neuroimaging Research Institute, Department of Radiology of the Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, ChinaChina-USA Neuroimaging Research Institute, Department of Radiology of the Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, ChinaTongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, ChinaChina-USA Neuroimaging Research Institute, Department of Radiology of the Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, ChinaDepressive symptoms are common in individuals with mild cognitive impairment (MCI) who have an increased risk of dementia. It is currently unclear whether the pattern of spontaneous brain activity in patients with MCI differs between subjects with and without depressive symptoms. The current study sought to investigate the features of spontaneous brain activity in MCI patients with depressive symptoms (D-MCI) using coherence regional homogeneity (CReHo) analysis with resting-state functional magnetic resonance imaging (rsfMRI). We obtained rsfMRI data in 16 MCI patients with depressive symptoms and 18 nondepressed MCI patients (nD-MCI) using a 3 T scanner. Statistical analyses were performed to determine the regions in which ReHo differed between the two groups in specific frequency bands, slow-4 (0.027–0.073 Hz) and slow-5 (0.010–0.027 Hz), and typical bands (0.01–0.08 Hz). Correlation analyses were performed between the CReHo index of these regions and clinical variables to evaluate the relationship between CReHo and pathophysiological measures in the two groups. Our results showed that D-MCI patients exhibited significantly higher CReHo in the left Heschl’s gyrus and left thalamus and lower CReHo in the left postcentral gyrus in the typical frequency band. In the slow-4 frequency band, D-MCI patients showed significantly higher CReHo in the left Heschl’s gyrus and left thalamus. In the slow-5 frequency band, D-MCI patients exhibited significantly lower CReHo in the superior medial prefrontal gyrus. In addition, the results revealed that CReHo values in the left thalamus were positively correlated with Hamilton Depression Rating Scale (HAMD) scores in D-MCI patients. These results suggest that the sensorimotor network may be one of the main pathophysiological factors in D-MCI.http://dx.doi.org/10.1155/2019/2981764 |
| spellingShingle | Xiaozheng Liu Yunhai Tu Yirou Zang Aiqin Wu Zhongwei Guo Jiawei He Disrupted Regional Spontaneous Neural Activity in Mild Cognitive Impairment Patients with Depressive Symptoms: A Resting-State fMRI Study Neural Plasticity |
| title | Disrupted Regional Spontaneous Neural Activity in Mild Cognitive Impairment Patients with Depressive Symptoms: A Resting-State fMRI Study |
| title_full | Disrupted Regional Spontaneous Neural Activity in Mild Cognitive Impairment Patients with Depressive Symptoms: A Resting-State fMRI Study |
| title_fullStr | Disrupted Regional Spontaneous Neural Activity in Mild Cognitive Impairment Patients with Depressive Symptoms: A Resting-State fMRI Study |
| title_full_unstemmed | Disrupted Regional Spontaneous Neural Activity in Mild Cognitive Impairment Patients with Depressive Symptoms: A Resting-State fMRI Study |
| title_short | Disrupted Regional Spontaneous Neural Activity in Mild Cognitive Impairment Patients with Depressive Symptoms: A Resting-State fMRI Study |
| title_sort | disrupted regional spontaneous neural activity in mild cognitive impairment patients with depressive symptoms a resting state fmri study |
| url | http://dx.doi.org/10.1155/2019/2981764 |
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