O-GlcNAcylation of the intellectual disability protein DDX3X exerts proteostatic cell cycle control

O-GlcNAcylation of the intellectual disability protein DDX3X exerts proteostatic cell cycle control

O-GlcNAcylation of intracellular proteins is a key regulator of diverse cellular and developmental processes. Previous studies have demonstrated the acute sensitivity of cell cycle progression to chemical and genetic manipulation of O-GlcNAc homeostasis. However, the mechanisms by which O-GlcNAc reg...

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Bibliographic Details
Main Authors: Conor W. Mitchell, Huijie Yuan, Marie Sønderstrup-Jensen, Andrew T. Ferenbach, Daan M. F. van Aalten
Format: Article
Language:English
Published: The Royal Society 2025-01-01
Series:Open Biology
Subjects:
O-GlcNAc
cell cycle
cell signalling
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.250064
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