Correlation of clinical and neurophysiological findings with health related quality of life in patients with diabetic polyneuropathy
Background/Aim. Diabetic polyneuropathy is defined as the presence of clinical or subclinical symptoms and/or signs of peripheral nerve damage in patients with diabetes mellitus in the absence of the other causes of peripheral neuropathy. The aim of this study was to assess healthrelated...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2014-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501400015V.pdf |
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| author | Vukojević Zoran Pekmezović Tatjana Nikolić Ana Perić Stojan Basta Ivana Marjanović Ivan Lavrnić Dragana |
| author_facet | Vukojević Zoran Pekmezović Tatjana Nikolić Ana Perić Stojan Basta Ivana Marjanović Ivan Lavrnić Dragana |
| author_sort | Vukojević Zoran |
| collection | DOAJ |
| description | Background/Aim. Diabetic polyneuropathy is defined as the presence of
clinical or subclinical symptoms and/or signs of peripheral nerve damage in
patients with diabetes mellitus in the absence of the other causes of
peripheral neuropathy. The aim of this study was to assess healthrelated
quality of life (HRQoL) in patients with diabetic polyneuropathy and its
correlation with clinical and neurophysiological findings. Methods. This
study comprised 60 patients with distal, symmetric, sensorimotor diabetic
polyneuropathy and type 2 diabetes mellitus. For evaluation of clinical
findings the following scales were used: Medical Research Council strenth
score (MRC sum score), Inflammatory Neuropathy Cause and Treatment (INCAT)
disability scale (arm disability and leg disability scales), INCAT sensory
sum score, Hamilton depression and anxiety rating scales. Nerve conduction
study (NCS) was performed on the motor part of the median and peroneal
nerves, the sensory part of the median nerve and sural nerve. All the
patients completed the Serbian version of the SF-36 questionnaire as a
measure of HRQoL. Results. Our results showed mild to moderate QoL impairment
in the patients with diabetic polyneuropathy with no difference in physical
and mental composite scores (p > 0.05). The age of the patients, mean MRC sum
score, arm disability scale score, leg disability scale score and mean INCAT
sensory sum score correlated with scores in the SF-36 questionnaire (p <
0.01). The patients with higher scores of anxiety and depression had
significantly worse health perception for all QoL domains, for both composite
scores and for the total SF-36 score (p < 0.01). Both motor and sensory NCS
parameters of the median nerve showed significant correlations with QoL
scores (p < 0.05). Conclusion. Our results showed mild to moderate QoL
impairment in the patients with diabetic polyneuropathy. HRQoL significantly
correlated with the age of the patients, muscle strength, disability, sensory
complaints, depressiveness and anxiety of the patients. Electrophysiological
examination of median nerve significantly correlated with QoL in the patients
with diabetic polyneuropathy. [Projekat Ministarstva nauke Republike Srbije,
br. 175087 and 175083] |
| format | Article |
| id | doaj-art-a86154c1b2424db1afcf6afbc0205e99 |
| institution | OA Journals |
| issn | 0042-8450 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-a86154c1b2424db1afcf6afbc0205e992025-08-20T02:00:37ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502014-01-0171983383810.2298/VSP120919015V0042-84501400015VCorrelation of clinical and neurophysiological findings with health related quality of life in patients with diabetic polyneuropathyVukojević Zoran0Pekmezović Tatjana1Nikolić Ana2Perić Stojan3Basta Ivana4Marjanović Ivan5Lavrnić Dragana6Neurology Clinic, Clinical Center Banja Luka, Bosnia and HerzegovinaInstitute of Epidemiology, Faculty of Medicine, Belgrade + Neurology Clinic, Clinical Center of Serbia, Faculty of Medicine, BelgradeNeurology Clinic, Clinical Center of Serbia, Faculty of Medicine, BelgradeNeurology Clinic, Clinical Center of Serbia, Faculty of Medicine, BelgradeNeurology Clinic, Clinical Center of Serbia, Faculty of Medicine, BelgradeNeurology Clinic, Clinical Center of Serbia, Faculty of Medicine, BelgradeNeurology Clinic, Clinical Center of Serbia, Faculty of Medicine, BelgradeBackground/Aim. Diabetic polyneuropathy is defined as the presence of clinical or subclinical symptoms and/or signs of peripheral nerve damage in patients with diabetes mellitus in the absence of the other causes of peripheral neuropathy. The aim of this study was to assess healthrelated quality of life (HRQoL) in patients with diabetic polyneuropathy and its correlation with clinical and neurophysiological findings. Methods. This study comprised 60 patients with distal, symmetric, sensorimotor diabetic polyneuropathy and type 2 diabetes mellitus. For evaluation of clinical findings the following scales were used: Medical Research Council strenth score (MRC sum score), Inflammatory Neuropathy Cause and Treatment (INCAT) disability scale (arm disability and leg disability scales), INCAT sensory sum score, Hamilton depression and anxiety rating scales. Nerve conduction study (NCS) was performed on the motor part of the median and peroneal nerves, the sensory part of the median nerve and sural nerve. All the patients completed the Serbian version of the SF-36 questionnaire as a measure of HRQoL. Results. Our results showed mild to moderate QoL impairment in the patients with diabetic polyneuropathy with no difference in physical and mental composite scores (p > 0.05). The age of the patients, mean MRC sum score, arm disability scale score, leg disability scale score and mean INCAT sensory sum score correlated with scores in the SF-36 questionnaire (p < 0.01). The patients with higher scores of anxiety and depression had significantly worse health perception for all QoL domains, for both composite scores and for the total SF-36 score (p < 0.01). Both motor and sensory NCS parameters of the median nerve showed significant correlations with QoL scores (p < 0.05). Conclusion. Our results showed mild to moderate QoL impairment in the patients with diabetic polyneuropathy. HRQoL significantly correlated with the age of the patients, muscle strength, disability, sensory complaints, depressiveness and anxiety of the patients. Electrophysiological examination of median nerve significantly correlated with QoL in the patients with diabetic polyneuropathy. [Projekat Ministarstva nauke Republike Srbije, br. 175087 and 175083]http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501400015V.pdfdiabetic neuropathiesneurophysiologyquality of lifequestionnaires |
| spellingShingle | Vukojević Zoran Pekmezović Tatjana Nikolić Ana Perić Stojan Basta Ivana Marjanović Ivan Lavrnić Dragana Correlation of clinical and neurophysiological findings with health related quality of life in patients with diabetic polyneuropathy Vojnosanitetski Pregled diabetic neuropathies neurophysiology quality of life questionnaires |
| title | Correlation of clinical and neurophysiological findings with health related quality of life in patients with diabetic polyneuropathy |
| title_full | Correlation of clinical and neurophysiological findings with health related quality of life in patients with diabetic polyneuropathy |
| title_fullStr | Correlation of clinical and neurophysiological findings with health related quality of life in patients with diabetic polyneuropathy |
| title_full_unstemmed | Correlation of clinical and neurophysiological findings with health related quality of life in patients with diabetic polyneuropathy |
| title_short | Correlation of clinical and neurophysiological findings with health related quality of life in patients with diabetic polyneuropathy |
| title_sort | correlation of clinical and neurophysiological findings with health related quality of life in patients with diabetic polyneuropathy |
| topic | diabetic neuropathies neurophysiology quality of life questionnaires |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501400015V.pdf |
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