Risk factors for subsequent vertebral fractures after percutaneous vertebral augmentation in Asian populations: a systematic review and meta-analysis
Abstract Objective To identify the risk factors for subsequent vertebral fractures after percutaneous vertebral augmentation through the meta-analysis. Methods Articles from 2019 to 2024 were retrieved from PubMed, Cochrane Library, Embase, and Web of Science. The quality of included studies was ass...
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BMC
2025-08-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-025-08998-x |
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| author | Weijie Zheng Jiexin Huang Liang Jin Qiaoli Zhang TianFeng Li WanChen Gong Yuchen Xia Zhengyi Lin Fei Zhou Chengwu Lu Libao Zhang Changhui Xue Hong Ye Linfeng Wang |
| author_facet | Weijie Zheng Jiexin Huang Liang Jin Qiaoli Zhang TianFeng Li WanChen Gong Yuchen Xia Zhengyi Lin Fei Zhou Chengwu Lu Libao Zhang Changhui Xue Hong Ye Linfeng Wang |
| author_sort | Weijie Zheng |
| collection | DOAJ |
| description | Abstract Objective To identify the risk factors for subsequent vertebral fractures after percutaneous vertebral augmentation through the meta-analysis. Methods Articles from 2019 to 2024 were retrieved from PubMed, Cochrane Library, Embase, and Web of Science. The quality of included studies was assessed using the Newcastle–Ottawa Scale (NOS), while data analysis was performed with R (The R Project for Statistical Computing). Results Fourteen articles comprising data from 5,673 patients were included in the analysis. Statistically significant differences were identified for age, gender, T-score (measured by dual-energy X-ray absorptiometry), body mass index (BMI), Computed tomography Hounsfield unit (CT HU) value, intravertebral cleft (IVC), multi-segment vertebral fractures, and bone cement leakage. In contrast, no statistically significant differences were observed for hypertension history, diabetes history, thoracolumbar vertebral fracture, postoperative Cobb angle, surgical method（percutaneous vertebroplasty/percutaneous kyphoplasty）, puncture method (unilateral/bilateral puncture), or bone cement volume. Conclusion In Asian populations, advanced age, female, low T-score, low BMI, low CT HU values, presence of IVC, multi-segment vertebral fractures, and bone cement leakage are identified as significant risk factors for subsequent vertebral fractures following PVA. Conversely, a history of anti-osteoporosis treatment is identified as a protective factor, whereas hypertension history, diabetes history, thoracolumbar vertebral fracture, postoperative Cobb angle, surgical method, puncture method, and bone cement volume demonstrate no significant correlation with subsequent vertebral fractures after PVA. |
| format | Article |
| id | doaj-art-a85b8e3d6ada4acaa501a3a9b4a37247 |
| institution | Kabale University |
| issn | 1471-2474 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj-art-a85b8e3d6ada4acaa501a3a9b4a372472025-08-20T03:46:57ZengBMCBMC Musculoskeletal Disorders1471-24742025-08-0126111210.1186/s12891-025-08998-xRisk factors for subsequent vertebral fractures after percutaneous vertebral augmentation in Asian populations: a systematic review and meta-analysisWeijie Zheng0Jiexin Huang1Liang Jin2Qiaoli Zhang3TianFeng Li4WanChen Gong5Yuchen Xia6Zhengyi Lin7Fei Zhou8Chengwu Lu9Libao Zhang10Changhui Xue11Hong Ye12Linfeng Wang13Department of Orthopedic Surgery, Nanping First Hospital Affiliated to Fujian Medical UniversityDepartment of Orthopedic Surgery, Nanping First Hospital Affiliated to Fujian Medical UniversityDepartment of Orthopedic Surgery, Nanping First Hospital Affiliated to Fujian Medical UniversityDepartment of Orthopedic Surgery, Nanping First Hospital Affiliated to Fujian Medical UniversityDepartment of Orthopedic Surgery, Nanping First Hospital Affiliated to Fujian Medical UniversityDepartment of Orthopedic Surgery, Nanping First Hospital Affiliated to Fujian Medical UniversityDepartment of Orthopedic Surgery, Nanping First Hospital Affiliated to Fujian Medical UniversityDepartment of Orthopedic Surgery, Nanping First Hospital Affiliated to Fujian Medical UniversityDepartment of Orthopedic Surgery, Nanping First Hospital Affiliated to Fujian Medical UniversityDepartment of Orthopedic Surgery, Nanping First Hospital Affiliated to Fujian Medical UniversityDepartment of Orthopedic Surgery, Nanping First Hospital Affiliated to Fujian Medical UniversityDepartment of Orthopedic Surgery, Nanping First Hospital Affiliated to Fujian Medical UniversityDepartment of Orthopedic Surgery, Nanping First Hospital Affiliated to Fujian Medical UniversityDepartment of Orthopedic Surgery, Nanping First Hospital Affiliated to Fujian Medical UniversityAbstract Objective To identify the risk factors for subsequent vertebral fractures after percutaneous vertebral augmentation through the meta-analysis. Methods Articles from 2019 to 2024 were retrieved from PubMed, Cochrane Library, Embase, and Web of Science. The quality of included studies was assessed using the Newcastle–Ottawa Scale (NOS), while data analysis was performed with R (The R Project for Statistical Computing). Results Fourteen articles comprising data from 5,673 patients were included in the analysis. Statistically significant differences were identified for age, gender, T-score (measured by dual-energy X-ray absorptiometry), body mass index (BMI), Computed tomography Hounsfield unit (CT HU) value, intravertebral cleft (IVC), multi-segment vertebral fractures, and bone cement leakage. In contrast, no statistically significant differences were observed for hypertension history, diabetes history, thoracolumbar vertebral fracture, postoperative Cobb angle, surgical method（percutaneous vertebroplasty/percutaneous kyphoplasty）, puncture method (unilateral/bilateral puncture), or bone cement volume. Conclusion In Asian populations, advanced age, female, low T-score, low BMI, low CT HU values, presence of IVC, multi-segment vertebral fractures, and bone cement leakage are identified as significant risk factors for subsequent vertebral fractures following PVA. Conversely, a history of anti-osteoporosis treatment is identified as a protective factor, whereas hypertension history, diabetes history, thoracolumbar vertebral fracture, postoperative Cobb angle, surgical method, puncture method, and bone cement volume demonstrate no significant correlation with subsequent vertebral fractures after PVA.https://doi.org/10.1186/s12891-025-08998-xPercutaneous vertebral augmentationSubsequent vertebral fracturesOsteoporotic vertebral compression fractureMeta-Analysis |
| spellingShingle | Weijie Zheng Jiexin Huang Liang Jin Qiaoli Zhang TianFeng Li WanChen Gong Yuchen Xia Zhengyi Lin Fei Zhou Chengwu Lu Libao Zhang Changhui Xue Hong Ye Linfeng Wang Risk factors for subsequent vertebral fractures after percutaneous vertebral augmentation in Asian populations: a systematic review and meta-analysis BMC Musculoskeletal Disorders Percutaneous vertebral augmentation Subsequent vertebral fractures Osteoporotic vertebral compression fracture Meta-Analysis |
| title | Risk factors for subsequent vertebral fractures after percutaneous vertebral augmentation in Asian populations: a systematic review and meta-analysis |
| title_full | Risk factors for subsequent vertebral fractures after percutaneous vertebral augmentation in Asian populations: a systematic review and meta-analysis |
| title_fullStr | Risk factors for subsequent vertebral fractures after percutaneous vertebral augmentation in Asian populations: a systematic review and meta-analysis |
| title_full_unstemmed | Risk factors for subsequent vertebral fractures after percutaneous vertebral augmentation in Asian populations: a systematic review and meta-analysis |
| title_short | Risk factors for subsequent vertebral fractures after percutaneous vertebral augmentation in Asian populations: a systematic review and meta-analysis |
| title_sort | risk factors for subsequent vertebral fractures after percutaneous vertebral augmentation in asian populations a systematic review and meta analysis |
| topic | Percutaneous vertebral augmentation Subsequent vertebral fractures Osteoporotic vertebral compression fracture Meta-Analysis |
| url | https://doi.org/10.1186/s12891-025-08998-x |
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