Antimicrobial effect of Dialkylcarbamoyl chloride (DACC) on infected surgical wounds. Experimental study
To evaluate the antimicrobial and histopathological effects of Dialkylcarbamoyl chloride (DACC) dressing on surgical wounds infected with various pathogens. In Group 1 (control), after the midline incision on interscapular region, wounds were closed with non–absorbable sutures in sterile conditions...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidad del Zulia
2025-07-01
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| Series: | Revista Científica |
| Subjects: | |
| Online Access: | https://produccioncientificaluz.org/index.php/cientifica/article/view/44098 |
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| Summary: | To evaluate the antimicrobial and histopathological effects of Dialkylcarbamoyl chloride (DACC) dressing on surgical wounds infected with various pathogens. In Group 1 (control), after the midline incision on interscapular region, wounds were closed with non–absorbable sutures in sterile conditions and nitrofurazone was applied externally to the surgical wounds. Wounds were covered with sterile gauze. In Group 2, 3, 4, and 5 rats were incised and wounds were contaminated with Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Candida albicans, respectively. Contaminated surgical wounds were covered with DACC dressing just after the incision. Dressings were changed every after 3 day. In all groups it was clearly seen that DACC showed antimicrobial effect against various microorganisms on surgical site infections. In 2nd group epithelial thickness of samples were decreased when compared to control group but it was no statistically significant. Also in this group fibrosis was statistically less than other groups. DACC covered dressing is a strategical biomechanic infection preventing material can be used against surgical site infection riscs safely. It has no any side effect known due to external uses. The hidrophobicity of DACC lets high binding capacity for microorganisms.
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| ISSN: | 0798-2259 2521-9715 |