In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cells.

In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cells.

α-Synuclein is a small protein strongly implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders. We report here the use of in-cell NMR spectroscopy to observe directly the structure and dynamics of this protein within E. coli cells. To improve the accuracy...

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Main Authors: Christopher A Waudby, Carlo Camilloni, Anthony W P Fitzpatrick, Lisa D Cabrita, Christopher M Dobson, Michele Vendruscolo, John Christodoulou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0072286&type=printable
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