The clinicopathologic characteristics and tumor immune microenvironment of pulmonary enteric adenocarcinoma
Background Pulmonary enteric adenocarcinoma (PEAC) as a rare subtype of lung adenocarcinoma is sparsely reported. Currently, to achieve effective treatment and accurate prognosis prediction, the exploration of molecular markers is ongoing.Methods This study retrospectively enrolled 10 patients with...
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2519675 |
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| author | Lan Yang Lingru Chen Jiali Gong Hongyang Lu |
| author_facet | Lan Yang Lingru Chen Jiali Gong Hongyang Lu |
| author_sort | Lan Yang |
| collection | DOAJ |
| description | Background Pulmonary enteric adenocarcinoma (PEAC) as a rare subtype of lung adenocarcinoma is sparsely reported. Currently, to achieve effective treatment and accurate prognosis prediction, the exploration of molecular markers is ongoing.Methods This study retrospectively enrolled 10 patients with PEAC confirmed by pathology at Zhejiang Cancer Hospital from April 2015 to July 2021. The investigation focused on their clinicopathological features and the tumor immune microenvironment. The expression of LAG-3, PD-L1, and MMR proteins was determined by immunohistochemistry in 7 patients with adequate tissue. Simultaneously, the levels and distribution of CD3, CD8A, CD45RO and PanCK in PEAC patients were measured by multiple immunohistochemical methods to explore and analyze the classification of TIME.Results A total of 10 patient pathologically diagnosed as PEAC, the mean age at diagnosis is 60.3 years, and 60% of them were male. The median follow-up for PFS subjects was 16.7 months (95%CI: 4.92–28.48 months). The median OS was 93.9 months (95% CI: 0–216.03 months). All the 7 patients in this study exhibited microsatellite stability (MSS), and PD-L1 expression was negative. Of the 7 patients, only one expressed LAG-3. The analysis of TIME in PEAC patients suggested ‘cold tumors’, meaning these patients may not benefit from immunotherapy.Conclusion PEAC is a rare histological variant of LAUD that occurs predominantly in middle-aged and elderly males. Its morphological characteristics are similar to colorectal adenocarcinoma, and the NaspinA, TTF-1, CK7, CDX2 and CK20 are beneficial for diagnosis. In this study, PEAC patients showed low CD8+ T cell, CD45RO+ T cell and LAG-3 expression, and negative PD-L1 expression. And all patients were MMS. |
| format | Article |
| id | doaj-art-a85779638e68493c817454a48ec44d2a |
| institution | OA Journals |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-a85779638e68493c817454a48ec44d2a2025-08-20T02:21:54ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2519675The clinicopathologic characteristics and tumor immune microenvironment of pulmonary enteric adenocarcinomaLan Yang0Lingru Chen1Jiali Gong2Hongyang Lu3Department of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, ChinaDepartment of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, ChinaDepartment of Hematology and Oncology, Ningbo No. 2 Hospital, Ningbo, ChinaThe Second Clinical Medical College, Wenzhou Medical University, Wenzhou, PR ChinaBackground Pulmonary enteric adenocarcinoma (PEAC) as a rare subtype of lung adenocarcinoma is sparsely reported. Currently, to achieve effective treatment and accurate prognosis prediction, the exploration of molecular markers is ongoing.Methods This study retrospectively enrolled 10 patients with PEAC confirmed by pathology at Zhejiang Cancer Hospital from April 2015 to July 2021. The investigation focused on their clinicopathological features and the tumor immune microenvironment. The expression of LAG-3, PD-L1, and MMR proteins was determined by immunohistochemistry in 7 patients with adequate tissue. Simultaneously, the levels and distribution of CD3, CD8A, CD45RO and PanCK in PEAC patients were measured by multiple immunohistochemical methods to explore and analyze the classification of TIME.Results A total of 10 patient pathologically diagnosed as PEAC, the mean age at diagnosis is 60.3 years, and 60% of them were male. The median follow-up for PFS subjects was 16.7 months (95%CI: 4.92–28.48 months). The median OS was 93.9 months (95% CI: 0–216.03 months). All the 7 patients in this study exhibited microsatellite stability (MSS), and PD-L1 expression was negative. Of the 7 patients, only one expressed LAG-3. The analysis of TIME in PEAC patients suggested ‘cold tumors’, meaning these patients may not benefit from immunotherapy.Conclusion PEAC is a rare histological variant of LAUD that occurs predominantly in middle-aged and elderly males. Its morphological characteristics are similar to colorectal adenocarcinoma, and the NaspinA, TTF-1, CK7, CDX2 and CK20 are beneficial for diagnosis. In this study, PEAC patients showed low CD8+ T cell, CD45RO+ T cell and LAG-3 expression, and negative PD-L1 expression. And all patients were MMS.https://www.tandfonline.com/doi/10.1080/07853890.2025.2519675PEACMMRLAG-3PD-L1IHCmIHC |
| spellingShingle | Lan Yang Lingru Chen Jiali Gong Hongyang Lu The clinicopathologic characteristics and tumor immune microenvironment of pulmonary enteric adenocarcinoma Annals of Medicine PEAC MMR LAG-3 PD-L1 IHC mIHC |
| title | The clinicopathologic characteristics and tumor immune microenvironment of pulmonary enteric adenocarcinoma |
| title_full | The clinicopathologic characteristics and tumor immune microenvironment of pulmonary enteric adenocarcinoma |
| title_fullStr | The clinicopathologic characteristics and tumor immune microenvironment of pulmonary enteric adenocarcinoma |
| title_full_unstemmed | The clinicopathologic characteristics and tumor immune microenvironment of pulmonary enteric adenocarcinoma |
| title_short | The clinicopathologic characteristics and tumor immune microenvironment of pulmonary enteric adenocarcinoma |
| title_sort | clinicopathologic characteristics and tumor immune microenvironment of pulmonary enteric adenocarcinoma |
| topic | PEAC MMR LAG-3 PD-L1 IHC mIHC |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2519675 |
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