Progress on responsive neurostimulation in treatment of drug⁃resistant epilepsy
Epilepsy is a common chronic neurological disorder that severely impacts the quality of life and social functioning. Approximately 1/3 of patients are diagnosed with drug⁃resistant epilepsy (DRE), for which conventional antiepileptic seizure medicine (ASM) and traditional surgery have limited effica...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2025-01-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
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| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/2975 |
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| author | FAN Xiu⁃liang BAI Yu⁃tong YANG An⁃chao ZHANG Kai |
| author_facet | FAN Xiu⁃liang BAI Yu⁃tong YANG An⁃chao ZHANG Kai |
| author_sort | FAN Xiu⁃liang |
| collection | DOAJ |
| description | Epilepsy is a common chronic neurological disorder that severely impacts the quality of life and social functioning. Approximately 1/3 of patients are diagnosed with drug⁃resistant epilepsy (DRE), for which conventional antiepileptic seizure medicine (ASM) and traditional surgery have limited efficacy. In recent years, responsive neurostimulation (RNS), as a closed⁃loop neuromodulation technique, has provided a novel treatment option for DRE. The RNS utilizes invasived electrodes to monitor brain activity in real time, detect seizure precursors, and deliver electrical stimulation, effectively reducing the frequency and severity of DRE. This paper aims to review the composition of the RNS, optimization and dyanmic adjustment of stimulation parameters, long⁃term data recording and analysis, fusion with machine learning, clinical efficacy, and comparison with vagus nerve stimulation (VNS). It also explores the technical challenges and discusses future development directions. RNS holds promise for providing personalized and precise treatment to more DRE and expanding its application to other neurological disorders. |
| format | Article |
| id | doaj-art-a855c82a10f34be38eb7fb4d551939fd |
| institution | Kabale University |
| issn | 1672-6731 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj-art-a855c82a10f34be38eb7fb4d551939fd2025-02-07T10:25:07ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312025-01-01251111610.3969/j.issn.1672⁃6731.2025.01.002Progress on responsive neurostimulation in treatment of drug⁃resistant epilepsyFAN Xiu⁃liang0BAI Yu⁃tong1YANG An⁃chao2ZHANG Kai3Center of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaCenter of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China Beijing Neurosurgical Institute; Beijing Key Laboratory of Neurostimulation, Capital Medical University, Beijing 100070, China； National Engineering Research Center for Neuromodulation, Beijing 100084, ChinaCenter of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China Beijing Neurosurgical Institute; Beijing Key Laboratory of Neurostimulation, Capital Medical University, Beijing 100070, China； National Engineering Research Center for Neuromodulation, Beijing 100084, ChinaCenter of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaEpilepsy is a common chronic neurological disorder that severely impacts the quality of life and social functioning. Approximately 1/3 of patients are diagnosed with drug⁃resistant epilepsy (DRE), for which conventional antiepileptic seizure medicine (ASM) and traditional surgery have limited efficacy. In recent years, responsive neurostimulation (RNS), as a closed⁃loop neuromodulation technique, has provided a novel treatment option for DRE. The RNS utilizes invasived electrodes to monitor brain activity in real time, detect seizure precursors, and deliver electrical stimulation, effectively reducing the frequency and severity of DRE. This paper aims to review the composition of the RNS, optimization and dyanmic adjustment of stimulation parameters, long⁃term data recording and analysis, fusion with machine learning, clinical efficacy, and comparison with vagus nerve stimulation (VNS). It also explores the technical challenges and discusses future development directions. RNS holds promise for providing personalized and precise treatment to more DRE and expanding its application to other neurological disorders.http://www.cjcnn.org/index.php/cjcnn/article/view/2975drug resistant epilepsyelectric stimulation therapyvagus nerve stimulationreview |
| spellingShingle | FAN Xiu⁃liang BAI Yu⁃tong YANG An⁃chao ZHANG Kai Progress on responsive neurostimulation in treatment of drug⁃resistant epilepsy Chinese Journal of Contemporary Neurology and Neurosurgery drug resistant epilepsy electric stimulation therapy vagus nerve stimulation review |
| title | Progress on responsive neurostimulation in treatment of drug⁃resistant epilepsy |
| title_full | Progress on responsive neurostimulation in treatment of drug⁃resistant epilepsy |
| title_fullStr | Progress on responsive neurostimulation in treatment of drug⁃resistant epilepsy |
| title_full_unstemmed | Progress on responsive neurostimulation in treatment of drug⁃resistant epilepsy |
| title_short | Progress on responsive neurostimulation in treatment of drug⁃resistant epilepsy |
| title_sort | progress on responsive neurostimulation in treatment of drug⁃resistant epilepsy |
| topic | drug resistant epilepsy electric stimulation therapy vagus nerve stimulation review |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/2975 |
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