Serum tyrosine increases all-cause mortality in an older population
PurposeAmino acids play crucial roles in metabolic and cardiovascular diseases, especially branched-chain and aromatic amino acids, but their association with mortality remains understudied and inconclusive. This study explored the potential correlation between serum amino acids levels (including le...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1552752/full |
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| author | Yuhong Dai Yong Zhang Yue Zhang Haoran Zheng Ling Xiang Liang Cheng Xiaoqing Wang Jie Zhang Hairong Hao De Huai Wen Hu |
| author_facet | Yuhong Dai Yong Zhang Yue Zhang Haoran Zheng Ling Xiang Liang Cheng Xiaoqing Wang Jie Zhang Hairong Hao De Huai Wen Hu |
| author_sort | Yuhong Dai |
| collection | DOAJ |
| description | PurposeAmino acids play crucial roles in metabolic and cardiovascular diseases, especially branched-chain and aromatic amino acids, but their association with mortality remains understudied and inconclusive. This study explored the potential correlation between serum amino acids levels (including leucine(Leu), isoleucine(Ile), valine(Val), phenylalanine(Phe), and tyrosine (Tyr) and all-cause or cardiovascular deaths in an older population.MethodsThis study involved 1,238 older people selected from the Huai’an Diabetes Prevention Program aged ≥ 60 years. Baseline serum levels of five amino acids (Leu, Ile, Val, Phe and Tyr) were measured. Participants were followed for 9 years. Cox regression analysis and Fine-Gray subdistribution hazard analysis were employed to assess the association between amino acids with all-cause or cardiovascular mortality. The prognostic value of amino acids was further assessed using the C index and Net Reclassification Improvement (NRI).Results1 During the 9-year follow-up, 69 deaths occurred, including 32 from cardiovascular causes. Preliminary univariable analyses showed that only serum Tyr levels were associated with the risk of all-cause mortality among the five amino acids (per 1-μg/mL increase in Tyr, HR = 1.08, 95% CI = 1.01-1.17). 2 After adjustment for potential confounders, the HR and 95% CI of all-cause mortality for serum Tyr levels from the lowest to the highest quartile was 1.00 (reference), 1.31 (0.59-2.92), 2.17 (1.23-4.60), and 2.18 (1.01-4.71), respectively. 3 Compared with the traditional risk predictive model (C index = 0.773), adding serum Tyr levels increased the C index (C index = 0.787) and NRI (NRI = 0.267) for predicting all-cause mortality.ConclusionsElevated serum tyrosine levels are independently associated with an increased risk of all-cause mortality, and may serve as a valuable biomarker for mortality risk prediction in Chinese older adults. |
| format | Article |
| id | doaj-art-a84ca53c07be47c2ba9e808381d246f8 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-a84ca53c07be47c2ba9e808381d246f82025-08-21T09:24:41ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-07-011610.3389/fendo.2025.15527521552752Serum tyrosine increases all-cause mortality in an older populationYuhong Dai0Yong Zhang1Yue Zhang2Haoran Zheng3Ling Xiang4Liang Cheng5Xiaoqing Wang6Jie Zhang7Hairong Hao8De Huai9Wen Hu10Department of Endocrinology and Metabolism, The Affiliated Huai′an Hospital of Xuzhou Medical University, Huai′an, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Huai′an Hospital of Xuzhou Medical University, Huai′an, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Huai′an Hospital of Xuzhou Medical University, Huai′an, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Huai′an Hospital of Xuzhou Medical University, Huai′an, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Huai′an Hospital of Xuzhou Medical University, Huai′an, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Huai′an Hospital of Xuzhou Medical University, Huai′an, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Huai′an Hospital of Xuzhou Medical University, Huai′an, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Huai′an Hospital of Xuzhou Medical University, Huai′an, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Huai′an Hospital of Xuzhou Medical University, Huai′an, ChinaDepartment of Head and Neck Surgery, The Affiliated Huai′an Hospital of Xuzhou Medical University, Huai′an, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Huai′an Hospital of Xuzhou Medical University, Huai′an, ChinaPurposeAmino acids play crucial roles in metabolic and cardiovascular diseases, especially branched-chain and aromatic amino acids, but their association with mortality remains understudied and inconclusive. This study explored the potential correlation between serum amino acids levels (including leucine(Leu), isoleucine(Ile), valine(Val), phenylalanine(Phe), and tyrosine (Tyr) and all-cause or cardiovascular deaths in an older population.MethodsThis study involved 1,238 older people selected from the Huai’an Diabetes Prevention Program aged ≥ 60 years. Baseline serum levels of five amino acids (Leu, Ile, Val, Phe and Tyr) were measured. Participants were followed for 9 years. Cox regression analysis and Fine-Gray subdistribution hazard analysis were employed to assess the association between amino acids with all-cause or cardiovascular mortality. The prognostic value of amino acids was further assessed using the C index and Net Reclassification Improvement (NRI).Results1 During the 9-year follow-up, 69 deaths occurred, including 32 from cardiovascular causes. Preliminary univariable analyses showed that only serum Tyr levels were associated with the risk of all-cause mortality among the five amino acids (per 1-μg/mL increase in Tyr, HR = 1.08, 95% CI = 1.01-1.17). 2 After adjustment for potential confounders, the HR and 95% CI of all-cause mortality for serum Tyr levels from the lowest to the highest quartile was 1.00 (reference), 1.31 (0.59-2.92), 2.17 (1.23-4.60), and 2.18 (1.01-4.71), respectively. 3 Compared with the traditional risk predictive model (C index = 0.773), adding serum Tyr levels increased the C index (C index = 0.787) and NRI (NRI = 0.267) for predicting all-cause mortality.ConclusionsElevated serum tyrosine levels are independently associated with an increased risk of all-cause mortality, and may serve as a valuable biomarker for mortality risk prediction in Chinese older adults.https://www.frontiersin.org/articles/10.3389/fendo.2025.1552752/fullamino acidstyrosineall-cause mortalityChinaolder population |
| spellingShingle | Yuhong Dai Yong Zhang Yue Zhang Haoran Zheng Ling Xiang Liang Cheng Xiaoqing Wang Jie Zhang Hairong Hao De Huai Wen Hu Serum tyrosine increases all-cause mortality in an older population Frontiers in Endocrinology amino acids tyrosine all-cause mortality China older population |
| title | Serum tyrosine increases all-cause mortality in an older population |
| title_full | Serum tyrosine increases all-cause mortality in an older population |
| title_fullStr | Serum tyrosine increases all-cause mortality in an older population |
| title_full_unstemmed | Serum tyrosine increases all-cause mortality in an older population |
| title_short | Serum tyrosine increases all-cause mortality in an older population |
| title_sort | serum tyrosine increases all cause mortality in an older population |
| topic | amino acids tyrosine all-cause mortality China older population |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1552752/full |
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