Quantitative renal [99mTc]DMSA imaging predicts urinary [99mTc]DMSA excretion in patients with chronic kidney disease
Abstract Background 99mTc-labelled Dimercaptosuccinic acid ([99mTc]DMSA) is a radiopharmaceutical commonly used to evaluate renal perfusion, structure, and morphology. However, the renal handling of [99mTc]DMSA in humans remains unclear. Studies in humans with renal tubular dysfunction and animal ex...
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SpringerOpen
2025-06-01
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| Series: | EJNMMI Research |
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| Online Access: | https://doi.org/10.1186/s13550-025-01272-0 |
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| author | Danny Jensen Jesper Frank Andersen Peder Berg Henrik Birn Christian Flø Jørgen Frøkiær |
| author_facet | Danny Jensen Jesper Frank Andersen Peder Berg Henrik Birn Christian Flø Jørgen Frøkiær |
| author_sort | Danny Jensen |
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| description | Abstract Background 99mTc-labelled Dimercaptosuccinic acid ([99mTc]DMSA) is a radiopharmaceutical commonly used to evaluate renal perfusion, structure, and morphology. However, the renal handling of [99mTc]DMSA in humans remains unclear. Studies in humans with renal tubular dysfunction and animal experiments suggest that renal uptake of [99mTc]DMSA occurs by glomerular filtration and subsequent proximal tubule reabsorption. The main aim of this study was to examine renal handling of [99mTc]DMSA and the pathophysiological implications of [99mTc]DMSA-based imaging in patients with chronic kidney disease (CKD) compared to healthy controls (HC). Results Urinary excretion of [99mTc]DMSA was 1.5-fold higher and more variable in CKD patients compared to HC. While [99mTc]DMSA plasma clearance was only 1.1-fold higher in HC, the [99mTc]DMSA uptake in the kidneys was 2.6-fold higher in HC compared to CKD patients and correlated inversely with the 24-hour urine excretion of [99mTc]DMSA independent of GFR. Conclusion Kidney [99mTc]DMSA accumulation is consistent with tubular uptake following glomerular filtration. The relative DMSA uptake is lower in CKD patients, pointing to defective proximal tubular function in this patient group. Furthermore, the results suggest that [99mTc]DMSA uptake could serve as a marker for tubule-interstitial function. |
| format | Article |
| id | doaj-art-a84c3f224a624ac79a586115e413a9df |
| institution | OA Journals |
| issn | 2191-219X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SpringerOpen |
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| spelling | doaj-art-a84c3f224a624ac79a586115e413a9df2025-08-20T02:37:35ZengSpringerOpenEJNMMI Research2191-219X2025-06-0115111010.1186/s13550-025-01272-0Quantitative renal [99mTc]DMSA imaging predicts urinary [99mTc]DMSA excretion in patients with chronic kidney diseaseDanny Jensen0Jesper Frank Andersen1Peder Berg2Henrik Birn3Christian Flø4Jørgen Frøkiær5Department of Emergency Medicine, Goedstrup HospitalDepartment of Biomedicine, Aarhus UniversityDepartment of Biomedicine, Aarhus UniversityDepartment of Renal Medicine, Aarhus University HospitalDepartment of Nuclear Medicine, Aarhus University HospitalDepartment of Nuclear Medicine, Aarhus University HospitalAbstract Background 99mTc-labelled Dimercaptosuccinic acid ([99mTc]DMSA) is a radiopharmaceutical commonly used to evaluate renal perfusion, structure, and morphology. However, the renal handling of [99mTc]DMSA in humans remains unclear. Studies in humans with renal tubular dysfunction and animal experiments suggest that renal uptake of [99mTc]DMSA occurs by glomerular filtration and subsequent proximal tubule reabsorption. The main aim of this study was to examine renal handling of [99mTc]DMSA and the pathophysiological implications of [99mTc]DMSA-based imaging in patients with chronic kidney disease (CKD) compared to healthy controls (HC). Results Urinary excretion of [99mTc]DMSA was 1.5-fold higher and more variable in CKD patients compared to HC. While [99mTc]DMSA plasma clearance was only 1.1-fold higher in HC, the [99mTc]DMSA uptake in the kidneys was 2.6-fold higher in HC compared to CKD patients and correlated inversely with the 24-hour urine excretion of [99mTc]DMSA independent of GFR. Conclusion Kidney [99mTc]DMSA accumulation is consistent with tubular uptake following glomerular filtration. The relative DMSA uptake is lower in CKD patients, pointing to defective proximal tubular function in this patient group. Furthermore, the results suggest that [99mTc]DMSA uptake could serve as a marker for tubule-interstitial function.https://doi.org/10.1186/s13550-025-01272-0DMSA scintigraphyEDTA clearanceChronic kidney diseaseGFRProximal tubular function |
| spellingShingle | Danny Jensen Jesper Frank Andersen Peder Berg Henrik Birn Christian Flø Jørgen Frøkiær Quantitative renal [99mTc]DMSA imaging predicts urinary [99mTc]DMSA excretion in patients with chronic kidney disease EJNMMI Research DMSA scintigraphy EDTA clearance Chronic kidney disease GFR Proximal tubular function |
| title | Quantitative renal [99mTc]DMSA imaging predicts urinary [99mTc]DMSA excretion in patients with chronic kidney disease |
| title_full | Quantitative renal [99mTc]DMSA imaging predicts urinary [99mTc]DMSA excretion in patients with chronic kidney disease |
| title_fullStr | Quantitative renal [99mTc]DMSA imaging predicts urinary [99mTc]DMSA excretion in patients with chronic kidney disease |
| title_full_unstemmed | Quantitative renal [99mTc]DMSA imaging predicts urinary [99mTc]DMSA excretion in patients with chronic kidney disease |
| title_short | Quantitative renal [99mTc]DMSA imaging predicts urinary [99mTc]DMSA excretion in patients with chronic kidney disease |
| title_sort | quantitative renal 99mtc dmsa imaging predicts urinary 99mtc dmsa excretion in patients with chronic kidney disease |
| topic | DMSA scintigraphy EDTA clearance Chronic kidney disease GFR Proximal tubular function |
| url | https://doi.org/10.1186/s13550-025-01272-0 |
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